Cdh8 cadherin 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdh8provided by MGI
Official Full Name: cadherin 8provided by MGI
Primary source: MGI:MGI:107434
See related: Ensembl:ENSMUSG00000036510 AllianceGenome:MGI:107434
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cad8
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein exhibit reduced behavioral responses to cold, but not thermal stimuli. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]
Expression: Biased expression in CNS E18 (RPKM 7.5), whole brain E14.5 (RPKM 4.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D1; 8 49.4 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (99751103..100144298, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (99024471..99417666, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The autism-associated protein CHD8 is required for cerebellar development and motor function.
Title: The autism-associated protein CHD8 is required for cerebellar development and motor function.
Cdh8 has role in neurogenesis in the ventral telencephalon during development.
Title: Cadherin 8 regulates proliferation of cortical interneuron progenitors.
Results indicate that Cdh8 delineates developing corticostriatal circuits where it is a strong candidate for regulating the generation of normal cortical projections, neuronal morphology, and corticostriatal synapses
Title: Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits.
Study shows that bipolar cells BC2s and BC5s deliver visual input to neurons that compute direction of motion and demonstrate that Cdh8 and Cdh9 are required for assembly of the circuit.
Title: Type II cadherins guide assembly of a direction-selective retinal circuit.
Results describe individual monomer and dimer states and the monomer-dimer equilibrium of the mouse Type II cadherin-8 EC1 domain.
Title: Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins.
These results demonstrate that cad8 is essential for establishing the physiological coupling between cold-sensitive sensory neurons and their target DH neurons.
Title: Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224772

CDH8_1919 (e-PCR)
- UniSTS:462096

Cdh8 (e-PCR), detects polymorphism
- UniSTS:498317

Cdh8 (e-PCR), detects polymorphism
- UniSTS:507867

AI851472 (e-PCR)
- UniSTS:165596

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in synaptic cleft	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cadherin-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039154.2 → NP_001034243.1 cadherin-8 isoform 1 precursor

See identical proteins and their annotated locations for NP_001034243.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region that leads to a frameshift compared to variant 2. The resulting protein (isoform 1) is shorter and has a distinct C-terminus compared to isoform 2. This isoform (1) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AC103397, BC057581, BU058167

Consensus CDS

CCDS22569.1

UniProtKB/TrEMBL

Q8C375, Q8C449

Related

ENSMUSP00000090935.5, ENSMUST00000093249.11

Conserved Domains (3) summary

cd11304
Location:281 → 387

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:87 → 165

CA; Cadherin repeats

pfam01049
Location:653 → 708

Cadherin_C; Cadherin cytoplasmic region
NM_001285913.1 → NP_001272842.1 cadherin-8 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region and includes an alternate 3' terminal exon compared to variant 2. The resulting protein (isoform 3) is shorter and has a distinct C-terminus compared to isoform 2. This isoform (3) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AK044046, AK139334, BC057581, BU058167

Consensus CDS

CCDS72155.1

UniProtKB/TrEMBL

E9Q451, Q8BRK4

Related

ENSMUSP00000123619.2, ENSMUST00000155527.8

Conserved Domains (3) summary

cd11304
Location:281 → 387

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:87 → 165

CA; Cadherin repeats

pfam01049
Location:653 → 711

Cadherin_C; Cadherin cytoplasmic region
NM_001285914.1 → NP_001272843.1 cadherin-8 isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region and includes an alternate 3' terminal exon compared to variant 2. The resulting protein (isoform 4) is shorter and has a distinct C-terminus compared to isoform 2. This isoform (4) may undergo proteolytic processing similar to isoform 2.

Source sequence(s)

AK044046, AK139334, BC057581, BU058167

Consensus CDS

CCDS72156.1

UniProtKB/TrEMBL

E9PYB2, Q3UTL9

Related

ENSMUSP00000114507.2, ENSMUST00000142129.8

Conserved Domains (3) summary

cd11304
Location:281 → 387

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:87 → 165

CA; Cadherin repeats

pfam01049
Location:653 → 701

Cadherin_C; Cadherin cytoplasmic region
NM_007667.3 → NP_031693.2 cadherin-8 isoform 2 preproprotein

See identical proteins and their annotated locations for NP_031693.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest protein (isoform 2).

Source sequence(s)

AC103397, BC057581, BU058167

Consensus CDS

CCDS40448.1

UniProtKB/Swiss-Prot

G3UVU4, P97291

UniProtKB/TrEMBL

Q3UTL9

Related

ENSMUSP00000117326.2, ENSMUST00000128860.8

Conserved Domains (3) summary

cd11304
Location:281 → 387

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:87 → 165

CA; Cadherin repeats

pfam01049
Location:645 → 790

Cadherin_C; Cadherin cytoplasmic region

RNA

NR_133570.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate exon in the 3' terminus, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC102643, AC103397, BC060200, BU058167

Related

ENSMUST00000145601.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

99751103..100144298 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243274.1 → XP_030099134.1 cadherin-8 isoform X1

UniProtKB/Swiss-Prot

G3UVU4, P97291

UniProtKB/TrEMBL

Q3UTL9

Conserved Domains (3) summary

cd11304
Location:281 → 387

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:87 → 165

CA; Cadherin repeats

pfam01049
Location:645 → 790

Cadherin_C; Cadherin cytoplasmic region
XM_017312551.3 → XP_017168040.1 cadherin-8 isoform X3

Conserved Domains (2) summary

smart00112
Location:17 → 55

CA; Cadherin repeats

pfam01049
Location:98 → 243

Cadherin_C; Cadherin cytoplasmic region
XM_006530631.3 → XP_006530694.1 cadherin-8 isoform X1

See identical proteins and their annotated locations for XP_006530694.1

UniProtKB/Swiss-Prot

G3UVU4, P97291

UniProtKB/TrEMBL

Q3UTL9

Conserved Domains (3) summary

cd11304
Location:281 → 387

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:87 → 165

CA; Cadherin repeats

pfam01049
Location:645 → 790

Cadherin_C; Cadherin cytoplasmic region
XM_006530634.5 → XP_006530697.1 cadherin-8 isoform X2

UniProtKB/TrEMBL

Q8BRK4

Conserved Domains (3) summary

cd11304
Location:281 → 387

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:87 → 165

CA; Cadherin repeats

pfam01049
Location:645 → 700

Cadherin_C; Cadherin cytoplasmic region