Cdh15 cadherin 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdh15provided by MGI
Official Full Name: cadherin 15provided by MGI
Primary source: MGI:MGI:106672
See related: Ensembl:ENSMUSG00000031962 AllianceGenome:MGI:106672
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mcad; Cdh14
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Based on the expression of this gene in skeletal muscle, satellite cells and cerebellum, it was postulated that the encoded protein may be important for muscle development and regeneration. Mice lacking the encoded protein appear normal and display no discernible defects in skeletal musculature. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]
Expression: Biased expression in limb E14.5 (RPKM 10.0), cerebellum adult (RPKM 9.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 71.99 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (123575113..123594136)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (122848374..122867397)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cooperation of cis-elements during M-cadherin promoter activation.
Title: The cooperation of cis-elements during M-cadherin promoter activation.
PEPITEM/Cadherin 15 Axis Inhibits T Lymphocyte Infiltration and Glomerulonephritis in a Mouse Model of Systemic Lupus Erythematosus.
Title: PEPITEM/Cadherin 15 Axis Inhibits T Lymphocyte Infiltration and Glomerulonephritis in a Mouse Model of Systemic Lupus Erythematosus.
Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-gamma, CPT-1A and Mcad activities.
Title: Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet.
The recruitment of M-cadherin to lipid rafts during pre-fusion myogenesis events depended on interaction with p120 catenin, whereas the organization of microrafts was controlled by a small G protein, Rac1.
Title: Regulation of pre-fusion events: recruitment of M-cadherin to microrafts organized at fusion-competent sites of myogenic cells.
Treatment of satellite cells with M-cadherin in vitro stimulates cell division, whereas addition of anti-M-cadherin antibodies reduces the cell division rate.
Title: M-cadherin-mediated intercellular interactions activate satellite cell division.
M-cadherin-mediated signaling attenuates beta-catenin phosphorylation.
Title: M-cadherin-inhibited phosphorylation of ß-catenin augments differentiation of mouse myoblasts.
Inhibition of GSK-3beta activation by M-cadherin protects myoblasts against mitochondria-associated apoptosis during myogenic differentiation.
Title: Suppression of GSK-3β activation by M-cadherin protects myoblasts against mitochondria-associated apoptosis during myogenic differentiation.
These data suggest that Toxoplasma gondii is able to down regulate M-cadherin expression, leading to molecular modifications in the host cell surface that interfere with membrane fusion and consequently affect the myogenesis process.
Title: Toxoplasma gondii down modulates cadherin expression in skeletal muscle cells inhibiting myogenesis.
Observations identify a molecular mechanism by which MRFs regulate M-cadherin expression directly to ensure the terminal differentiation of myoblasts.
Title: Myogenic regulatory factors regulate M-cadherin expression by targeting its proximal promoter elements.
Biochemical experiments show that CDH23 homodimers interact in trans with PCDH15 homodimers to form a filament with structural similarity to tip links
Title: Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236035

Cdh15 (e-PCR), detects polymorphism
- UniSTS:238128

AI323380 (e-PCR)
- UniSTS:179837

Cdh15 (e-PCR), detects polymorphism
- UniSTS:546691

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin-15

Names: M-cadherin; cadherin-14; muscle cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007662.2 → NP_031688.2 cadherin-15 preproprotein

See identical proteins and their annotated locations for NP_031688.2

Status: REVIEWED

Source sequence(s)

AC132287, AC167359

Consensus CDS

CCDS22746.1

UniProtKB/Swiss-Prot

B2RXU1, P33146, Q9QYZ7

Related

ENSMUSP00000034443.6, ENSMUST00000034443.7

Conserved Domains (3) summary

cd11304
Location:155 → 255

Cadherin_repeat; Cadherin tandem repeat domain

pfam00028
Location:270 → 366

Cadherin; Cadherin domain

pfam01049
Location:639 → 782

Cadherin_C; Cadherin cytoplasmic region