Cd69 CD69 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd69provided by MGI
Official Full Name: CD69 antigenprovided by MGI
Primary source: MGI:MGI:88343
See related: Ensembl:ENSMUSG00000030156 AllianceGenome:MGI:88343
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AIM; VEA; 5830438K24Rik
Summary: Predicted to enable calcium ion binding activity and identical protein binding activity. Located in external side of plasma membrane. Orthologous to human CD69 (CD69 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 3.8), spleen adult (RPKM 1.1) and 6 other tissues See more
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Genomic context

Location:: 6 F3; 6 63.21 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129244287..129252332, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129267324..129275375, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD69 expression on regulatory T cells protects from immune damage after myocardial infarction.
Title: CD69 expression on regulatory T cells protects from immune damage after myocardial infarction.
The aberrant expression of CD69 on peripheral T-helper cells in diet-induced inflammation is ameliorated by low-dose aspirin and metformin treatment.
Title: The aberrant expression of CD69 on peripheral T-helper cells in diet-induced inflammation is ameliorated by low-dose aspirin and metformin treatment.
CD69 deficiency promotes a prothrombotic phenotype characterized by increased von Willebrand factor and worse brain damage after ischemic stroke. The results suggest that CD69 acts as a downregulator of endothelial activation.
Title: CD69 Plays a Beneficial Role in Ischemic Stroke by Dampening Endothelial Activation.
CD69 is important to the suppressive function of Tregs by promoting IL-10 production.
Title: CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production.
Oxidized low-density lipoprotein binding to CD69 confers a regulatory phenotype to mouse T cells, dampening Th17 responses and ameliorating atherosclerosis.
Title: Oxidized Low-Density Lipoprotein Receptor in Lymphocytes Prevents Atherosclerosis and Predicts Subclinical Disease.
This study reveals the importance of CD69 to prolong the thymic residency time of developing immature precursors for proper differentiation of a T cell subset, NKT2 cells.
Title: CD69 prevents PLZF(hi) innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation.
These studies showed that VCAM1 contributes not only to the initiation of myelination but also to its regulation through controlling the abundance of CD69, demonstrating that an intercellular molecule whose primary role is in the immune system can also play an unexpected role in the CNS.
Title: VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination.
AIM plays an orchestrating role in the resolution process of inflammation by altering the profile of pulmonary lipid mediators
Title: Orchestrating Role of Apoptosis Inhibitor of Macrophage in the Resolution of Acute Lung Injury.
Data show that a subset of inflammation-induced CD69(+) Kupffer cells which can feedback inhibit CD4 T cell response via cell surface TGF-beta1 at the late stage of immune response against infection.
Title: Inflammation-induced CD69(+) Kupffer cell feedback inhibits T cell proliferation via membrane-bound TGF-β1.
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
Title: Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (6)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484838

Cd69 (e-PCR), detects polymorphism
- UniSTS:141293

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: early activation antigen CD69

Names: Very Early Activation Antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033122.4 → NP_001028294.1 early activation antigen CD69

See identical proteins and their annotated locations for NP_001028294.1

Status: VALIDATED

Source sequence(s)

AK151076, BE691115, BY193860

Consensus CDS

CCDS20582.1

UniProtKB/Swiss-Prot

P37217

UniProtKB/TrEMBL

Q3U6A8

Related

ENSMUSP00000032259.4, ENSMUST00000032259.6

Conserved Domains (2) summary

cd03593
Location:85 → 196

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

PHA03097
Location:43 → 197

PHA03097; C-type lectin-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

129244287..129252332 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505463.3 → XP_006505526.1 early activation antigen CD69 isoform X1

Conserved Domains (1) summary

cd03593
Location:72 → 183

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)