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    Cd59a CD59a antigen [ Mus musculus (house mouse) ]

    Gene ID: 12509, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cd59aprovided by MGI
    Official Full Name
    CD59a antigenprovided by MGI
    Primary source
    MGI:MGI:109177
    See related
    Ensembl:ENSMUSG00000032679 AllianceGenome:MGI:109177
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd59; MACIF; MAC-IP
    Summary
    Predicted to enable complement binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of fibroblast growth factor production; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within negative regulation of activation of membrane attack complex. Located in external side of plasma membrane. Is expressed in several structures, including Meckel's cartilage; nervous system; neural retina; skeleton; and testis. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 34.6), subcutaneous fat pad adult (RPKM 26.7) and 24 other tissues See more
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    Genomic context

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    Location:
    2 E2; 2 54.53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103926177..103945755)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (104095753..104115410)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05279 Neighboring gene F-box protein 3 Neighboring gene predicted gene, 24644 Neighboring gene STARR-seq mESC enhancer starr_05280 Neighboring gene CD59b antigen Neighboring gene RIKEN cDNA A930018P22 gene Neighboring gene RIKEN cDNA D430041D05 gene Neighboring gene STARR-seq mESC enhancer starr_05283 Neighboring gene STARR-seq mESC enhancer starr_05284 Neighboring gene predicted gene, 22501

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration. Song D, et al. PLoS One, 2016. PMID 27893831, Free PMC Article
    2. Modulation of host CD59 expression by varicella-zoster virus in human xenografts in vivo. Wang W, et al. Virology, 2016 Apr. PMID 26891237
    3. Deletion of the membrane complement inhibitor CD59a drives age and gender-dependent alterations to bone phenotype in mice. Bloom AC, et al. Bone, 2016 Mar. PMID 26721735, Free PMC Article
    4. Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy. Marshall KM, et al. J Exp Med, 2014 Aug 25. PMID 25113972, Free PMC Article
    5. Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59. Zhang H, et al. J Autoimmun, 2014 Sep. PMID 24698947, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data (including data from studies using knockout mice) suggest that CD59a, CD59b, and ApoE are involved in development of diabetes-induced atherosclerosis; here, deficiency of CD59a/CD59b (in ApoE deficient mice) accelerates development of atherosclerosis in mice with type 1 diabetes. (CD59a = CD59a antigen; CD59b = CD59b antigen; ApoE = apolipoprotein E)
      Title: Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice.
    2. Varicella-zoster virus infection upregulates host CD59 expression in a tissue-specific manner.
      Title: Modulation of host CD59 expression by varicella-zoster virus in human xenografts in vivo.
    3. This study support a role of Cd59a in controlling the innate immune status of the RPE-choroidal complex and emphasizes the particular vulnerability of this ocular compartment to the dysregulation of alternative complement pathway during aging
      Title: Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age.
    4. results implicate CD59 as an important modulator of the immune response in NMO, and provide a novel animal model of NMO that closely recapitulates human NMO pathology.
      Title: Longitudinally extensive NMO spinal cord pathology produced by passive transfer of NMO-IgG in mice lacking complement inhibitor CD59.
    5. Soluble forms of CD59 (sCD59) have been investigated in mouse laser-induced choroidal neovascularization, a model for "wet" age related macular degeneration.
      Title: The complement regulatory protein CD59: insights into attenuation of choroidal neovascularization.
    6. both CD59 and C-PC could inhibit the progress of atherosclerosis, and the anti-atherosclerotic effects of C-PC might be fulfilled by promoting CD59 expression, preventing smooth muscle cell proliferation and the apoptosis of endothelial cells
      Title: CD59 underlines the antiatherosclerotic effects of C-phycocyanin on mice.
    7. CD59a inhibits systemic autoimmunity in MRL/lpr mice through a complement-independent mechanism.
      Title: Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice.
    8. While the connection between CFH deficiency and failure to upregulate CD59a remains unknown, these results suggest that expression of CD59 is tissue-specific and that neuroretinal regulation depends on CFH.
      Title: Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.
    9. Actively immunized experimental autoimmune myasthenia gravis mice deficient in either CD55 or CD59 showed significant differences in adaptive immune responses and worsened disease outcome associated with increased levels of serum cytokines, modified production of acetylcholine receptor antibodies, and more complement deposition at the neuromuscular junction.
      Title: DAF/CD55 and Protectin/CD59 modulate adaptive immunity and disease outcome in experimental autoimmune myasthenia gravis.
    10. HBx can up-regulate CD59 and Crry expression in podocytes through activating the P38 pathway.
      Title: [Hepatitis B virus X protein upregulates the expression of CD59 and Crry in mouse podocytes].
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables complement binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables complement binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of activation of membrane attack complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of activation of membrane attack complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of activation of membrane attack complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of activation of membrane attack complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of complement activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of complement-dependent cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fibroblast growth factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of complement-dependent cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in compact myelin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CD59A glycoprotein
    Names
    CD59 antigen
    MAC-inhibitory protein
    membrane attack complex inhibition factor
    protectin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111060.3 → NP_001104530.1  CD59A glycoprotein precursor

      See identical proteins and their annotated locations for NP_001104530.1

      Status: VALIDATED

      Source sequence(s)
      BX813317
      Consensus CDS
      CCDS16487.1
      UniProtKB/Swiss-Prot
      O55186, Q542R7
      UniProtKB/TrEMBL
      A2BI31, Q920G6
      Related
      ENSMUSP00000132774.2, ENSMUST00000168176.8
      Conserved Domains (1) summary
      smart00134
      Location:24 → 100
      LU; Ly-6 antigen / uPA receptor -like domain

    2. NM_001416923.1 → NP_001403852.1  CD59A glycoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      BX813317
      UniProtKB/Swiss-Prot
      O55186, Q542R7
      UniProtKB/TrEMBL
      A2BI31

    3. NM_001416924.1 → NP_001403853.1  CD59A glycoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      BX813317
      UniProtKB/Swiss-Prot
      O55186, Q542R7
      UniProtKB/TrEMBL
      A2BI31

    4. NM_001416925.1 → NP_001403854.1  CD59A glycoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      BX813317
      UniProtKB/Swiss-Prot
      O55186, Q542R7
      UniProtKB/TrEMBL
      A2BI31

    5. NM_007652.6 → NP_031678.1  CD59A glycoprotein precursor

      See identical proteins and their annotated locations for NP_031678.1

      Status: VALIDATED

      Source sequence(s)
      BX813317
      Consensus CDS
      CCDS16487.1
      UniProtKB/Swiss-Prot
      O55186, Q542R7
      UniProtKB/TrEMBL
      A2BI31, Q920G6
      Related
      ENSMUSP00000048041.6, ENSMUST00000040423.12
      Conserved Domains (1) summary
      smart00134
      Location:24 → 100
      LU; Ly-6 antigen / uPA receptor -like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      103926177..103945755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55186.1 GenPept UniProtKB/Swiss-Prot:O55186

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