Cd37 CD37 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd37provided by MGI
Official Full Name: CD37 antigenprovided by MGI
Primary source: MGI:MGI:88330
See related: Ensembl:ENSMUSG00000030798 AllianceGenome:MGI:88330
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tspan26
Summary: Acts upstream of or within several processes, including defense response to protozoan; negative regulation of myeloid dendritic cell activation; and positive regulation of immunoglobulin production. Predicted to be located in immunological synapse. Predicted to be integral component of plasma membrane. Is expressed in thymus primordium. Orthologous to human CD37 (CD37 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 338.0), mammary gland adult (RPKM 92.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.2 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44883056..44888701, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45233632..45239340, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

tetraspanin CD37 controls CLEC-2 membrane organization and provides new molecular insights into the mechanisms underlying CLEC-2-dependent dendritic cell migration.
Title: C-type lectin-like receptor 2 (CLEC-2)-dependent dendritic cell migration is controlled by tetraspanin CD37.
CD37 may protect against IgA nephropathy by inhibition of the IL-6 pathway.
Title: Interleukin-6 is essential for glomerular immunoglobulin A deposition and the development of renal pathology in Cd37-deficient mice.
this study identifies CD37 as a tumor suppressor that directly protects against B cell lymphomagenesis
Title: Tetraspanin CD37 protects against the development of B cell lymphoma.
The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model.
Title: The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model.
The cellular defect that underlies poor cellular immune induction in CD37-defcient mice is impaired dendritic cell migration.
Title: Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration.
CD37 was required for the mobility and clustering of alpha(4)beta(1) integrins in the plasma membrane, thus regulating the membrane distribution of alpha(4)beta(1) integrin necessary for activation of the Akt survival pathway
Title: The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival.
CD37 protects against glomerular IgA deposition and renal pathology
Title: The tetraspanin CD37 protects against glomerular IgA deposition and renal pathology.
tetraspanin protein CD37 inhibits IgA responses and regulates the anti-fungal immune response.
Title: The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity.
CD37 and CD151 control DC-mediated T-cell activation by two different mechanisms: CD151 regulates co-stimulation whereas CD37 regulates peptide/MHC presentation
Title: Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC.
The influence of CD37 in the early events of T cell receptor signaling demonstrates a regulatory role for CD37 in T cell proliferation.
Title: A regulatory role for CD37 in T cell proliferation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of myeloid dendritic cell activation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of defense response to virus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukocyte antigen CD37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290802.1 → NP_001277731.1 leukocyte antigen CD37 isoform 1

See identical proteins and their annotated locations for NP_001277731.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC150897, BY548149, CT010217, CX226822

Consensus CDS

CCDS71958.1

UniProtKB/TrEMBL

A0A1B0GSZ7, Q3U429

Related

ENSMUSP00000033063.7, ENSMUST00000033063.15

Conserved Domains (2) summary

cd03160
Location:130 → 265

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:48 → 292

Tetraspannin; Tetraspanin family
NM_001290804.1 → NP_001277733.1 leukocyte antigen CD37 isoform 2

See identical proteins and their annotated locations for NP_001277733.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to variant 1.

Source sequence(s)

AC150897, BE849269, BY548149, CT010217, CX226822

UniProtKB/TrEMBL

A0A1B0GS72

Related

ENSMUSP00000147818.2, ENSMUST00000210078.2

Conserved Domains (3) summary

cd03160
Location:105 → 240

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:21 → 267

Tetraspannin; Tetraspanin family

pfam13908
Location:1 → 44

Shisa; Wnt and FGF inhibitory regulator
NM_007645.4 → NP_031671.1 leukocyte antigen CD37 isoform 3

See identical proteins and their annotated locations for NP_031671.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC150897

Consensus CDS

CCDS21237.1

UniProtKB/Swiss-Prot

Q61470

UniProtKB/TrEMBL

A0A1B0GSZ7, Q4FK35

Related

ENSMUSP00000096061.2, ENSMUST00000098461.10

Conserved Domains (2) summary

cd03160
Location:108 → 243

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:26 → 270

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

44883056..44888701 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540593.5 → XP_006540656.1 leukocyte antigen CD37 isoform X2

Conserved Domains (1) summary

cd03160
Location:105 → 240

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
XM_006540592.5 → XP_006540655.1 leukocyte antigen CD37 isoform X1

Conserved Domains (1) summary

cd03160
Location:130 → 265

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...