Cd151 CD151 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd151provided by MGI
Official Full Name: CD151 antigenprovided by MGI
Primary source: MGI:MGI:1096360
See related: Ensembl:ENSMUSG00000025510 AllianceGenome:MGI:1096360
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SFA-1; PETA-3; Tspan24
Summary: Predicted to enable integrin binding activity. Acts upstream of or within T cell proliferation and cell migration. Predicted to be located in basement membrane and cell surface. Predicted to be integral component of plasma membrane. Orthologous to human CD151 (CD151 molecule (Raph blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 306.7), ovary adult (RPKM 269.4) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 86.82 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (141047275..141051394)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141467362..141471481)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Cd151 blocks the activating effect of miR-199a-3p on cardiomyocyte proliferation, suggesting Cd151 is a functional target of miR-199a-3p in cardiomyocytes.
Title: miR-199a-3p promotes cardiomyocyte proliferation by inhibiting Cd151 expression.
our study suggests that CD151 is a key player in the Wnt oncogene-driven tumorigenesis and impacts breast cancer malignancy in a cell type-dependent manner.
Title: Deletion of tetraspanin CD151 alters the Wnt oncogene-induced mammary tumorigenesis: A cell type-linked function and signaling.
CD151 is a critical novel host factor of nuclear export signaling.
Title: CD151, a novel host factor of nuclear export signaling in influenza virus infection.
in complex with P2Y12 receptor contributes to thrombus growth and stability
Title: A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y12 receptor in platelets.
Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation
Title: Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation.
Integrin-associated CD151 represses mammary branching morphogenesis by controlling progenitor cell activities, extracellular matrix integrity and transcription program.
Title: CD151 represses mammary gland development by maintaining the niches of progenitor cells.
Study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes.
Title: Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model.
We identify CD151 as a critical factor in tetradecanoylphorbol acetate-dependent skin carcinogenesis.
Title: Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151.
Loss of CD151 is associated with drug sensitivity in skin squamous cell carcinoma.
Title: Tetraspanin CD151 plays a key role in skin squamous cell carcinoma.
study provides strong evidence that CD151 collaborates with LB integrins (particularly alpha6beta4 and ErbB2 (and EGFR) receptors to regulate multiple signaling pathways, thereby driving mammary tumor onset, survival, and metastasis
Title: Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (5) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cd151 (e-PCR), detects polymorphism
- UniSTS:141265

Cd151 (e-PCR), detects polymorphism
- UniSTS:141266

Cd151 (e-PCR), detects polymorphism
- UniSTS:141267

Cd151 (e-PCR), detects polymorphism
- UniSTS:141268

Cd151 (e-PCR), detects polymorphism
- UniSTS:141269

D89290 (e-PCR)
- UniSTS:159717

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell migration	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CD151 antigen

Names: GP27; membrane glycoprotein SFA-1; platelet-endothelial tetraspan antigen 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111049.1 → NP_001104519.1 CD151 antigen

See identical proteins and their annotated locations for NP_001104519.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AI155754, AW539552, BQ896459, DV063036, U89772

Consensus CDS

CCDS22017.1

UniProtKB/Swiss-Prot

O35566, O89118

UniProtKB/TrEMBL

Q921J7

Related

ENSMUSP00000136331.2, ENSMUST00000177840.9

Conserved Domains (2) summary

cd03155
Location:112 → 220

CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:15 → 248

Tetraspannin; Tetraspanin family
NM_001111050.1 → NP_001104520.1 CD151 antigen

See identical proteins and their annotated locations for NP_001104520.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AI155754, AW539552, CJ066904, U89772

Consensus CDS

CCDS22017.1

UniProtKB/Swiss-Prot

O35566, O89118

UniProtKB/TrEMBL

Q921J7

Related

ENSMUSP00000061636.6, ENSMUST00000058746.7

Conserved Domains (2) summary

cd03155
Location:112 → 220

CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:15 → 248

Tetraspannin; Tetraspanin family
NM_009842.3 → NP_033972.2 CD151 antigen

See identical proteins and their annotated locations for NP_033972.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AI155754, AW539552, BQ896459, D89290, U89772

Consensus CDS

CCDS22017.1

UniProtKB/Swiss-Prot

O35566, O89118

UniProtKB/TrEMBL

Q921J7

Related

ENSMUSP00000101622.3, ENSMUST00000106000.10

Conserved Domains (2) summary

cd03155
Location:112 → 220

CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:15 → 248

Tetraspannin; Tetraspanin family