Ctnna1 catenin alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctnna1provided by MGI
Official Full Name: catenin alpha 1provided by MGI
Primary source: MGI:MGI:88274
See related: Ensembl:ENSMUSG00000037815 AllianceGenome:MGI:88274
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Catna1; 2010010M04Rik
Summary: Enables actin filament binding activity and identical protein binding activity. Involved in negative regulation of protein localization to nucleus. Acts upstream of or within several processes, including apical junction assembly; negative regulation of neuroblast proliferation; and regulation of signal transduction. Located in several cellular components, including intercalated disc; lamellipodium; and zonula adherens. Part of flotillin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study patterned macular dystrophy 2. Human ortholog(s) of this gene implicated in patterned macular dystrophy 2. Orthologous to human CTNNA1 (catenin alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 52.1), placenta adult (RPKM 48.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 18.89 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (35251955..35387829)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (35118902..35254776)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha-Catenin acetylation is essential for its stability and blocks its tumor suppressor effects in breast cancer through Yap1.
Title: α-Catenin acetylation is essential for its stability and blocks its tumor suppressor effects in breast cancer through Yap1.
beta-catenin has an TCF/LEF-independent nuclear function that coordinates an extensive network of myogenic genes in cooperation with MyoD; and an alpha-catenin-dependent membrane function that helps control cell-cell interactions
Title: β-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin.
alpha-catenin represents a bona fide tumor suppressor for the development of lobular-type breast cancer and as such provides an alternative event to E-cadherin inactivation, adherens junction dysfunction, and subsequent constitutive actomyosin contraction.
Title: αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer.
alphaE-catenin knockout caused heart failure, the upregulation of hypertrophic genes, and the dysregulation of fatty acid metabolism via the transcriptional activity of Yap and beta-catenin.
Title: Cardiospecific deletion of αE-catenin leads to heart failure and lethality in mice.
alphaE-catenin is essential for inhibiting nuclear YAP localization and cell proliferation. This function of alphaE-catenin is required for formation of the tooth signalling centre, the enamel knot (EK), which maintains dental mesenchymal condensation and epithelial invagination. alphaE-catenin restricts YAP/TAZ activity to establish a group of non-dividing and specialized cells that constitute a signalling centre.
Title: αE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development.
Catna1 functions as a positive regulator of pancreatic islet cell lineage differentiation by repressing the sonic hedgehog pathway.
Title: αE-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation.
alpha-catenins regulate intercalated disc maturation and actomyosin contractility, which, in turn, control Yap subcellular localization, thus providing an explanation for the loss of proliferative capacity in the newborn mammalian heart.
Title: α-Catenin-dependent cytoskeletal tension controls Yap activity in the heart.
In this study, the authors revealed how alpha-catenin retains its activated state while avoiding unfolding under tension.
Title: Mechano-adaptive sensory mechanism of α-catenin under tension.
cadherin 2 (CDH2) and CDH4 cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and alpha- and beta-catenins.
Title: Cadherin 2/4 signaling via PTP1B and catenins is crucial for nucleokinesis during radial neuronal migration in the neocortex.
alphaT-catenin is a constitutively active actin-binding protein that can physically couple the cadherin.catenin complex to F-actin in the absence of tension.
Title: αT-Catenin Is a Constitutive Actin-binding α-Catenin That Directly Couples the Cadherin·Catenin Complex to Actin Filaments.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Gene trapped (2) 1 citation
Chemically induced (ENU) (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124469 (e-PCR)
- UniSTS:161291

BB129880 (e-PCR)
- UniSTS:186127

RH126159 (e-PCR)
- UniSTS:162870

RH126174 (e-PCR)
- UniSTS:162870

Lrrtm2 (e-PCR), detects polymorphism
- UniSTS:498491

Lrrtm2 (e-PCR), detects polymorphism
- UniSTS:498492

AI851755 (e-PCR)
- UniSTS:181091

AI230960 (e-PCR)
- UniSTS:250042

AI988031 (e-PCR)
- UniSTS:166087

Ctnna1 (e-PCR), detects polymorphism
- UniSTS:506825

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info
enables vinculin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apical junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to indole-3-methanol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gap junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of flotillin complex	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in zonula adherens	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: catenin alpha-1

Names: 102 kDa cadherin-associated protein; CAP102; alpha E-catenin; cadherin associated protein; catenin (cadherin associated protein), alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009818.1 → NP_033948.1 catenin alpha-1

See identical proteins and their annotated locations for NP_033948.1

Status: PROVISIONAL

Source sequence(s)

X59990

Consensus CDS

CCDS29139.1

UniProtKB/Swiss-Prot

P26231

UniProtKB/TrEMBL

Q3TGQ3, Q545R0

Related

ENSMUSP00000049007.7, ENSMUST00000042345.8

Conserved Domains (1) summary

pfam01044
Location:82 → 867

Vinculin; Vinculin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

35251955..35387829

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250299.1 → XP_030106159.1 catenin alpha-1 isoform X1

UniProtKB/Swiss-Prot

P26231

UniProtKB/TrEMBL

Q3TGQ3, Q545R0

Conserved Domains (1) summary

pfam01044
Location:82 → 867

Vinculin; Vinculin family
XM_036160954.1 → XP_036016847.1 catenin alpha-1 isoform X2

Conserved Domains (1) summary

pfam01044
Location:1 → 497

Vinculin; Vinculin family
XM_006525548.4 → XP_006525611.1 catenin alpha-1 isoform X2

See identical proteins and their annotated locations for XP_006525611.1

Conserved Domains (1) summary

pfam01044
Location:1 → 497

Vinculin; Vinculin family