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    Car7 carbonic anhydrase 7 [ Mus musculus (house mouse) ]

    Gene ID: 12354, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Car7provided by MGI
    Official Full Name
    carbonic anhydrase 7provided by MGI
    Primary source
    MGI:MGI:103100
    See related
    Ensembl:ENSMUSG00000031883 AllianceGenome:MGI:103100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ca7
    Summary
    Enables carbonate dehydratase activity. Acts upstream of or within positive regulation of GABAergic synaptic transmission; positive regulation of cellular pH reduction; and regulation of chloride transport. Located in cytosol. Is expressed in several structures, including brain and genitourinary system. Orthologous to human CA7 (carbonic anhydrase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 10.1), cortex adult (RPKM 7.5) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Car7 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105261326..105276979)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104534694..104550347)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene predicted gene, 22148 Neighboring gene NEDD8 activating enzyme E1 subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E6676 Neighboring gene STARR-positive B cell enhancer ABC_E2873 Neighboring gene STARR-seq mESC enhancer starr_22513 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1767 Neighboring gene STARR-seq mESC enhancer starr_22514 Neighboring gene pyruvate dehydrogenase phosphatase catalytic subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Carbonic anhydrase seven bundles filamentous actin and regulates dendritic spine morphology and density. Bertling E, et al. EMBO Rep, 2021 Apr 7. PMID 33719157, Free PMC Article
    2. The catalytic properties of murine carbonic anhydrase VII. Earnhardt JN, et al. Biochemistry, 1998 Jul 28. PMID 9692974
    3. Expression of mouse carbonic anhydrase VII in E. coli and demonstration of its CO2 hydrase activity. Lakkis MM, et al. Biochem Biophys Res Commun, 1996 Sep 4. PMID 8806625
    4. Annexin VII relocalization as a result of dystrophin deficiency. Selbert S, et al. Exp Cell Res, 1996 Jan 10. PMID 8549664
    5. Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. Ruusuvuori E, et al. EMBO J, 2013 Aug 14. PMID 23881097, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures.
      Title: Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures.
    2. Car2, Car3, Car7, and Car15 mRNAs were barely within the detection limits in the mouse harderian gland.
      Title: Carbonic anhydrases in the mouse harderian gland.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cellular pH reduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of chloride transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbonic anhydrase 7
    Names
    CA-VII
    carbonate dehydratase VII
    carbonic anhydrase VII
    NP_001288093.1
    NP_001288094.1
    NP_001403595.1
    NP_444300.1
    XP_006530680.1
    XP_006530681.1
    XP_030099123.1
    XP_036009627.1
    XP_036009628.1
    XP_036009629.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301164.1 → NP_001288093.1  carbonic anhydrase 7 isoform b

      See identical proteins and their annotated locations for NP_001288093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate first exon and uses a downstream translation start site compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC130543, BC094913, BY741075
      Consensus CDS
      CCDS80920.1
      UniProtKB/TrEMBL
      G3XA26, Q3UND9
      Related
      ENSMUSP00000125112.2, ENSMUST00000159416.8
      Conserved Domains (1) summary
      cl00012
      Location:1 → 206
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    2. NM_001301165.1 → NP_001288094.1  carbonic anhydrase 7 isoform b

      See identical proteins and their annotated locations for NP_001288094.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate first exon and uses a downstream translation start site compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC130543, AK144275, BC094913
      Consensus CDS
      CCDS80920.1
      UniProtKB/TrEMBL
      G3XA26, Q3UND9
      Related
      ENSMUSP00000125404.2, ENSMUST00000162761.2
      Conserved Domains (1) summary
      cl00012
      Location:1 → 206
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    3. NM_001416666.1 → NP_001403595.1  carbonic anhydrase 7 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC130543
      UniProtKB/TrEMBL
      G3XA26

    4. NM_053070.3 → NP_444300.1  carbonic anhydrase 7 isoform a

      See identical proteins and their annotated locations for NP_444300.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer isoform (a).
      Source sequence(s)
      AC130543
      Consensus CDS
      CCDS22581.1
      UniProtKB/Swiss-Prot
      Q811X4, Q9ERQ8
      Related
      ENSMUSP00000052136.5, ENSMUST00000056051.11
      Conserved Domains (1) summary
      cd03149
      Location:27 → 262
      alpha_CA_VII; Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      105261326..105276979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153734.1 → XP_036009627.1  carbonic anhydrase 7 isoform X2

      UniProtKB/TrEMBL
      Q3UND9
      Conserved Domains (1) summary
      cl00012
      Location:50 → 232
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    2. XM_030243263.2 → XP_030099123.1  carbonic anhydrase 7 isoform X1

      Conserved Domains (1) summary
      cl00012
      Location:70 → 252
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    3. XM_036153735.1 → XP_036009628.1  carbonic anhydrase 7 isoform X4

      Conserved Domains (1) summary
      cl00012
      Location:2 → 158
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    4. XM_036153736.1 → XP_036009629.1  carbonic anhydrase 7 isoform X4

      Conserved Domains (1) summary
      cl00012
      Location:2 → 158
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    5. XM_006530617.4 → XP_006530680.1  carbonic anhydrase 7 isoform X3

      See identical proteins and their annotated locations for XP_006530680.1

      UniProtKB/TrEMBL
      G3XA26, Q3UND9
      Conserved Domains (1) summary
      cl00012
      Location:1 → 206
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    6. XM_006530618.4 → XP_006530681.1  carbonic anhydrase 7 isoform X3

      See identical proteins and their annotated locations for XP_006530681.1

      UniProtKB/TrEMBL
      G3XA26, Q3UND9
      Conserved Domains (1) summary
      cl00012
      Location:1 → 206
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERQ8.2 GenPept UniProtKB/Swiss-Prot:Q9ERQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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