Car6 carbonic anhydrase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Car6provided by MGI
Official Full Name: carbonic anhydrase 6provided by MGI
Primary source: MGI:MGI:1333786
See related: Ensembl:ENSMUSG00000028972 AllianceGenome:MGI:1333786
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ca6; DOC1
Summary: Predicted to enable carbonate dehydratase activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste and one-carbon metabolic process. Located in cytosol and extracellular space. Is expressed in brain. Orthologous to human CA6 (carbonic anhydrase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 81.12 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (150271472..150285592, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (150187015..150201135, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the nuclear localized CA-VI B selectively promotes IL-12 expression by interaction with protein arginine N-methyltransferase 5 (PRMT5), which reduces symmetric dimethylation of histone H3 arginine 8 modification (H3R8me2s) at Il12 promoters to facilitate chromatin accessibility, selectively enhancing c-Rel binding to the Il12b promoter.
Title: Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response.
he altered biological processes included antigen transport by M-cells, potassium transport, muscle contraction, and thyroid hormone synthesis. Immunohistochemical staining confirmed the absence of CA VI in the submandibular gland of Car6 (-/-) mice
Title: Altered gene expression in the lower respiratory tract of Car6 (-/-) mice.
knockout mouse model confirms that CA VI is involved in bitter taste perception. CA VI may be one of the factors which contribute to avoidance of bitter, potentially harmful, substances.
Title: The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6⁻/⁻ mouse model.
The generation of Car6 (-/-) mice and examination of the effects of CAVI deficiency on gene transcription have revealed several affected clusters of biological processes, which implicate CAVI in catabolic processes and the immune system response.
Title: Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice.
Car4, Car6, and Car12 showed moderate expression levels in the mouse harderian gland.
Title: Carbonic anhydrases in the mouse harderian gland.
expression of Car6 significantly decreased in enamel organs from Mmp20(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development.
Title: Altered ion-responsive gene expression in Mmp20 null mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

AF079834 (e-PCR)
- UniSTS:163356

RH137414 (e-PCR)
- UniSTS:219502

Car6 (e-PCR), detects polymorphism
- UniSTS:545906

Car6 (e-PCR), detects polymorphism
- UniSTS:525962

Car6 (e-PCR), detects polymorphism
- UniSTS:506776

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carbonic anhydrase 6

Names: CA-VI; carbonate dehydratase VI; carbonic anhydrase VI; salivary carbonic anhydrase; secreted carbonic anhydrase

NP_033932.2

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009802.2 → NP_033932.2 carbonic anhydrase 6 precursor

See identical proteins and their annotated locations for NP_033932.2

Status: VALIDATED

Source sequence(s)

AI323978, AK132599, AK161216

Consensus CDS

CCDS51386.1

UniProtKB/Swiss-Prot

B1ARR5, O88625, P18761

UniProtKB/TrEMBL

Q3V197, Q7TNG9

Related

ENSMUSP00000030817.5, ENSMUST00000030817.5

Conserved Domains (1) summary

cd03125
Location:30 → 278

alpha_CA_VI; Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed ...