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    Car1 carbonic anhydrase 1 [ Mus musculus (house mouse) ]

    Gene ID: 12346, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Car1provided by MGI
    Official Full Name
    carbonic anhydrase 1provided by MGI
    Primary source
    MGI:MGI:88268
    See related
    Ensembl:ENSMUSG00000027556 AllianceGenome:MGI:88268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ca1; Car-1
    Summary
    Predicted to enable arylesterase activity and carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including eye; limb; liver; nervous system; and skeleton. Orthologous to human CA1 (carbonic anhydrase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward colon adult (RPKM 847.4) See more
    Orthologs
    human all
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    Genomic context

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    See Car1 in Genome Data Viewer
    Location:
    3 A1; 3 3.18 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (14831274..14873425, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (14766214..14808365, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07003 Neighboring gene carbonic anhydrase 13 Neighboring gene STARR-seq mESC enhancer starr_07004 Neighboring gene carbonic anhydrase 1 pseudogene Neighboring gene cytochrome c oxidase, subunit VIc pseudogene Neighboring gene predicted gene, 41999 Neighboring gene STARR-positive B cell enhancer mm9_chr3:14869793-14870093 Neighboring gene STARR-positive B cell enhancer ABC_E10176 Neighboring gene STARR-seq mESC enhancer starr_07005 Neighboring gene STARR-positive B cell enhancer mm9_chr3:14880225-14880526 Neighboring gene carbonic anhydrase 3 Neighboring gene carbonic anhydrase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Upregulation of carbonic anhydrase 1 beneficial for depressive disorder. Cheng K, et al. Acta Neuropathol Commun, 2023 Apr 3. PMID 37013604, Free PMC Article
    2. Transgenic mice over-expressing carbonic anhydrase I showed aggravated joint inflammation and tissue destruction. Zheng Y, et al. BMC Musculoskelet Disord, 2012 Dec 20. PMID 23256642, Free PMC Article
    3. Regulatory dendritic cells pulsed with carbonic anhydrase I protect mice from colitis induced by CD4+CD25- T cells. Yamanishi H, et al. J Immunol, 2012 Mar 1. PMID 22291189
    4. Molecular evolution of the carbonic anhydrase genes: calculation of divergence time for mouse carbonic anhydrase I and II. Fraser PJ, et al. J Mol Evol, 1986. PMID 3104601
    5. The mouse carbonic anhydrase I gene contains two tissue-specific promoters. Fraser P, et al. Mol Cell Biol, 1989 Aug. PMID 2571923, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of carbonic anhydrase 1 beneficial for depressive disorder.
      Title: Upregulation of carbonic anhydrase 1 beneficial for depressive disorder.
    2. During inner ear development, transcripts of four cytosolic isozymes (Car1, Car2, Car3, and Car13), two membrane-bound isozymes (Car12 and Car14), and two CA-related proteins (Car8 and Car11) were expressed at higher levels than other isozymes.
      Title: A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development.
    3. Over-expression of CA1 may aggravate joint inflammation and tissue destruction in the transgenic mice.
      Title: Transgenic mice over-expressing carbonic anhydrase I showed aggravated joint inflammation and tissue destruction.
    4. Taken together, these data show that Ldb1 forms a regulatory complex to maintain Car1 expression in erythroid cells.
      Title: Ldb1 regulates carbonic anhydrase 1 during erythroid differentiation.
    5. Regulatory dendritic cells pulsed with carbonic anhydrase I suppress development of colitis in a severe combined immunodeficiency (SCID) mouse transfer model by inducing the differentiation of regulatory T cells in an antigen-specific manner.
      Title: Regulatory dendritic cells pulsed with carbonic anhydrase I protect mice from colitis induced by CD4+CD25- T cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118082

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbonate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyanamide hydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydro-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydro-lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 1
    Names
    CA-I
    carbonate dehydratase I
    carbonic anhydrase I
    cyanamide hydratase CA1
    NP_001077426.1
    NP_033929.2
    XP_011246439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083957.1 → NP_001077426.1  carbonic anhydrase 1

      See identical proteins and their annotated locations for NP_001077426.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 5' UTR compared to transcript variant 1. Both transcript variants (1 and 2) encode the same protein. This variant represents use of an alternate downstream promoter and results in colon epithelia cell expression.
      Source sequence(s)
      AK162331, AV374892
      Consensus CDS
      CCDS17248.1
      UniProtKB/Swiss-Prot
      P13634, Q3TS19, Q9DC84
      Related
      ENSMUSP00000091925.5, ENSMUST00000094365.11
      Conserved Domains (1) summary
      cl00012
      Location:2 → 261
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    2. NM_009799.4 → NP_033929.2  carbonic anhydrase 1

      See identical proteins and their annotated locations for NP_033929.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both transcript variants (1 and 2) encode the same protein. This variant represents use of an upstream long terminal repeat (LTR) promoter and exon sequence, and results in erythroid expression. (PMID: 2571923)
      Source sequence(s)
      AK003066, AK162331, AV374892, BB842334
      Consensus CDS
      CCDS17248.1
      UniProtKB/Swiss-Prot
      P13634, Q3TS19, Q9DC84
      Related
      ENSMUSP00000137926.2, ENSMUST00000181860.8
      Conserved Domains (1) summary
      cl00012
      Location:2 → 261
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      14831274..14873425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248137.1 → XP_011246439.1  carbonic anhydrase 1 isoform X1

      See identical proteins and their annotated locations for XP_011246439.1

      UniProtKB/Swiss-Prot
      P13634, Q3TS19, Q9DC84
      Conserved Domains (1) summary
      cl00012
      Location:2 → 261
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13634.4 GenPept UniProtKB/Swiss-Prot:P13634

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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