Capzb capping actin protein of muscle Z-line subunit beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Capzbprovided by MGI
Official Full Name: capping actin protein of muscle Z-line subunit betaprovided by MGI
Primary source: MGI:MGI:104652
See related: Ensembl:ENSMUSG00000028745 AllianceGenome:MGI:104652
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CPB1; CPB2; Cappb1; CPbeat2; CPbeta1; CPbeta2; 1700120C01Rik
Summary: This gene encodes the beta subunit of a highly conserved filamentous actin capping protein that binds the barbed end of filamentous actin to stabilize it and terminate elongation. Interaction of this protein with the barbed end of the actin filament occurs through binding of the amphipathic helix at the C-terminus to the hydrophobic cleft on the actin molecule. This gene is required for a variety of dynamic actin-mediated processes including organization of lamellipodia and filopodia, growth cone morphology and neurite outgrowth in hippocampal neurons, and asymmetric spindle migration and polar body extrusion during oocyte maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in bladder adult (RPKM 93.6), large intestine adult (RPKM 76.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 70.59 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (138920210..139019131)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (139192899..139291820)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZbeta.
Title: Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ.
Comparative Analysis of CPI-Motif Regulation of Biochemical Functions of Actin Capping Protein.
Title: Comparative Analysis of CPI-Motif Regulation of Biochemical Functions of Actin Capping Protein.
Capping protein CAPZB participates in stereocilia widening in auditory hair cells by preventing newly elongating actin filaments from depolymerizing.
Title: Heterodimeric capping protein is required for stereocilia length and width regulation.
with strain there was significant PKCepsilon translocation to the Z-disc and co-localization with CapZbeta1 or alpha-actinin, which was quantified on confocal images.
Title: Cyclic mechanical strain of myocytes modifies CapZβ1 post translationally via PKCε.
Capping protein-beta knockdown decreases filopodial length, alters filopodial shape, and reduces filopodial dynamics.
Title: Capping protein is essential for cell migration in vivo and for filopodial morphology and dynamics.
Actin-capping protein is a novel regulator of microtubule stability that functions by antagonizing mDia1 activity toward actin filaments.
Title: Actin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1.
This study suggested that increased expression of TrkB and Capzb2 accompanies adequate brain reserve in the initial stages of AD pathology.
Title: Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology.
Capzb2 plays an important role in growth cone formation and neurite outgrowth and that the underlying mechanism may involve direct interaction between Capzb2 and microtubules.
Title: Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth.
BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress.
Title: BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress.
Capping protein interacts with both actin protomers at the barbed end of the filament, and the amphipathic helix at the C-terminus of the beta-subunit binds to the hydrophobic cleft on actin.
Title: The interaction of capping protein with the barbed end of the actin filament.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin filament capping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin polymerization or depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
part_of WASH complex	ISO Inferred from Sequence Orthology more info
is_active_in asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in sperm connecting piece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: F-actin-capping protein subunit beta

Names: capZ beta; capping protein (actin filament) muscle Z-line, beta; capping protein beta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037761.2 → NP_001032850.1 F-actin-capping protein subunit beta isoform a

See identical proteins and their annotated locations for NP_001032850.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.

Source sequence(s)

BQ030615, BY033332, BY124858, BY415700, U10406

Consensus CDS

CCDS18842.1

UniProtKB/Swiss-Prot

A2AMV7, P47757

UniProtKB/TrEMBL

Q3TVK4

Related

ENSMUSP00000099565.4, ENSMUST00000102507.10

Conserved Domains (1) summary

pfam01115
Location:11 → 239

F_actin_cap_B; F-actin capping protein, beta subunit
NM_001271405.1 → NP_001258334.1 F-actin-capping protein subunit beta isoform c

See identical proteins and their annotated locations for NP_001258334.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate 5'-terminal exon and has multiple differences in the coding region, one of which results in use of an alternate start codon. It encodes isoform (c), which is shorter than and has distinct N- and C-termini compared to isoform a.

Source sequence(s)

AL807811

Consensus CDS

CCDS71503.1

UniProtKB/TrEMBL

Q3TVK4

Related

ENSMUSP00000030518.10, ENSMUST00000030518.16

Conserved Domains (1) summary

pfam01115
Location:35 → 269

F_actin_cap_B; F-actin capping protein, beta subunit
NM_009798.4 → NP_033928.1 F-actin-capping protein subunit beta isoform b

See identical proteins and their annotated locations for NP_033928.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in translation extending to a distinct 3' coding region compared to variant 1. The encoded isoform (b) is shorter than and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AK168738, BY033332, BY415700

Consensus CDS

CCDS18841.1

UniProtKB/TrEMBL

Q3TVK4, Q923G3

Related

ENSMUSP00000099566.4, ENSMUST00000102508.10

Conserved Domains (1) summary

pfam01115
Location:11 → 239

F_actin_cap_B; F-actin capping protein, beta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

138920210..139019131

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538504.4 → XP_006538567.1 F-actin-capping protein subunit beta isoform X1

UniProtKB/TrEMBL

Q3TVK4

Conserved Domains (1) summary

pfam01115
Location:35 → 269

F_actin_cap_B; F-actin capping protein, beta subunit

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001271406.1: Suppressed sequence

Description

NM_001271406.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.