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    Capn7 calpain 7 [ Mus musculus (house mouse) ]

    Gene ID: 12339, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Capn7provided by MGI
    Official Full Name
    calpain 7provided by MGI
    Primary source
    MGI:MGI:1338030
    See related
    Ensembl:ENSMUSG00000021893 AllianceGenome:MGI:1338030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PalBH
    Summary
    Predicted to enable MIT domain binding activity and endopeptidase activity. Involved in proteolysis. Predicted to be located in centrosome and cytosol. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human CAPN7 (calpain 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 22.2), CNS E14 (RPKM 19.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Capn7 in Genome Data Viewer
    Location:
    14 B; 14 19.1 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31058582..31093944)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31336622..31371987)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Brca1 associated protein 1 Neighboring gene dynein, axonemal, heavy chain 1 Neighboring gene predicted gene, 35823 Neighboring gene STARR-positive B cell enhancer ABC_E10823 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32149566-32149675 Neighboring gene SH3-domain binding protein 5 (BTK-associated) Neighboring gene STARR-seq mESC enhancer starr_36314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:32229701-32230002 Neighboring gene predicted gene, 35907 Neighboring gene PRELI domain-containing protein 2 pseudogene Neighboring gene methyltransferase 6, methylcytidine

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB. Futai E, et al. Biochim Biophys Acta, 2001 Jan 26. PMID 11342116
    2. Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain. Franz T, et al. Mamm Genome, 1999 Mar. PMID 10051333
    3. Calpain7 impairs embryo implantation by downregulating β3-integrin expression via degradation of HOXA10. Yan Q, et al. Cell Death Dis, 2018 Feb 19. PMID 29459744, Free PMC Article
    4. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus. Gafni J, et al. J Biol Chem, 2004 May 7. PMID 14981075
    5. Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development. Dear TN, et al. Mech Dev, 1999 Dec. PMID 10559499

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of CAPN7 in Ishikawa cells or in the uterus of mice inhibited embryo implantation in vitro and in vivo.
      Title: Calpain7 impairs embryo implantation by downregulating β3-integrin expression via degradation of HOXA10.
    2. calpain-derived Htt fragmentation has a role in Huntington's disease and aberrant activation of calpains may play a role in HD pathogenesis
      Title: Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MIT domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in self proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calpain-7
    Names
    palB homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360187.2 → NP_001347116.1  calpain-7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108416
      Conserved Domains (3) summary
      smart00720
      Location:643 → 766
      calpain_III; calpain_III domain
      cd00044
      Location:170 → 494
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cl00299
      Location:41 → 113
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

    2. NM_001422190.1 → NP_001409119.1  calpain-7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC108416

    3. NM_001422191.1 → NP_001409120.1  calpain-7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108416

    4. NM_001422192.1 → NP_001409121.1  calpain-7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108416

    5. NM_001422193.1 → NP_001409122.1  calpain-7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108416

    6. NM_001422194.1 → NP_001409123.1  calpain-7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108416

    7. NM_001422195.1 → NP_001409124.1  calpain-7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC108416

    8. NM_009796.4 → NP_033926.1  calpain-7 isoform 1

      See identical proteins and their annotated locations for NP_033926.1

      Status: VALIDATED

      Source sequence(s)
      AC108416
      Consensus CDS
      CCDS26911.1
      UniProtKB/Swiss-Prot
      Q9R1S8, Q9Z0P9
      Related
      ENSMUSP00000022451.8, ENSMUST00000022451.14
      Conserved Domains (4) summary
      smart00720
      Location:687 → 810
      calpain_III; calpain_III domain
      cd00044
      Location:214 → 538
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd02681
      Location:5 → 76
      MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
      cl00299
      Location:85 → 157
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

    RNA

    1. NR_185495.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108416

    2. NR_185496.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108416

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31058582..31093944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158431.1 → XP_036014324.1  calpain-7 isoform X2

      Conserved Domains (4) summary
      smart00720
      Location:593 → 716
      calpain_III; calpain_III domain
      cd00044
      Location:214 → 538
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd02681
      Location:5 → 76
      MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
      cl00299
      Location:85 → 157
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

    2. XM_036158430.1 → XP_036014323.1  calpain-7 isoform X1

      Conserved Domains (2) summary
      smart00720
      Location:522 → 645
      calpain_III; calpain_III domain
      cd00044
      Location:49 → 373
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1S8.1 GenPept UniProtKB/Swiss-Prot:Q9R1S8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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