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    Calcr calcitonin receptor [ Mus musculus (house mouse) ]

    Gene ID: 12311, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Calcrprovided by MGI
    Official Full Name
    calcitonin receptorprovided by MGI
    Primary source
    MGI:MGI:101950
    See related
    Ensembl:ENSMUSG00000023964 AllianceGenome:MGI:101950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clr; Ct-r
    Summary
    Enables calcitonin receptor activity. Acts upstream of or within several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of ossification; and osteoclast differentiation. Located in acrosomal vesicle and cilium. Is expressed in several structures, including brain; gonad; limb long bone; mammary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (calcitonin receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 1.5), CNS E18 (RPKM 1.2) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A1; 6 1.81 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (3685678..3764713, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (3685678..3764713, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene VPS50 EARP/GARPII complex subunit Neighboring gene predicted gene, 52885 Neighboring gene STARR-seq mESC enhancer starr_14998 Neighboring gene STARR-seq mESC enhancer starr_14999 Neighboring gene STARR-seq mESC enhancer starr_15001 Neighboring gene STARR-seq mESC enhancer starr_15002 Neighboring gene predicted gene, 53306 Neighboring gene microRNA 653 Neighboring gene microRNA 489 Neighboring gene predicted gene, 33576 Neighboring gene STARR-seq mESC enhancer starr_15003 Neighboring gene STARR-seq mESC enhancer starr_15005 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_15006 Neighboring gene tissue factor pathway inhibitor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of Calcr expressing neurons in the medial amygdala in social contact among females. Fukumitsu K, et al. Mol Brain, 2023 Jan 19. PMID 36658598, Free PMC Article
    2. The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis. Maleitzke T, et al. iScience, 2022 Jan 21. PMID 35036874, Free PMC Article
    3. Paraventricular Calcitonin Receptor-Expressing Neurons Modulate Energy Homeostasis in Male Mice. Gonzalez IE, et al. Endocrinology, 2021 Jun 1. PMID 33834205, Free PMC Article
    4. The calcitonin receptor regulates osteocyte lacunae acidity during lactation in mice. Davey RA, et al. J Endocrinol, 2021 Apr. PMID 33638943
    5. Calcitonin receptor is required for T-antigen-induced prostate carcinogenesis. Kale A, et al. Oncotarget, 2020 Mar 3. PMID 32180899, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of Calcr expressing neurons in the medial amygdala in social contact among females.
      Title: Role of Calcr expressing neurons in the medial amygdala in social contact among females.
    2. Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care.
      Title: Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care.
    3. Paraventricular Calcitonin Receptor-Expressing Neurons Modulate Energy Homeostasis in Male Mice.
      Title: Paraventricular Calcitonin Receptor-Expressing Neurons Modulate Energy Homeostasis in Male Mice.
    4. The calcitonin receptor regulates osteocyte lacunae acidity during lactation in mice.
      Title: The calcitonin receptor regulates osteocyte lacunae acidity during lactation in mice.
    5. Endosomal signaling of the CLR mediates pain transmission.
      Title: Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.
    6. calcitonin receptor is expressed in the suprachiasmatic nucleus and mediates body temperature fluctuations during the active phase in mice.
      Title: Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals.
    7. Calcr knockout resulted in abnormal quiescent state of muscle stem cells, reduction of their pool apoptosis and relocation from the MSC niche.
      Title: Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche.
    8. data suggest that Clr-b modulation is a conserved innate host cell response to virus infection that is subverted by multiple CMV immune evasion strategies.
      Title: Modulation of Clr Ligand Expression and NKR-P1 Receptor Function during Murine Cytomegalovirus Infection.
    9. upregulated in synovial tissue of osteoarthritic mice by macrophage-derived IL-1 beta
      Title: Synovial macrophage-derived IL-1β regulates the calcitonin receptor in osteoarthritic mice.
    10. protects the maternal skeleton during lactation by a direct action on osteocytes to inhibit osteolysis
      Title: A Role for the Calcitonin Receptor to Limit Bone Loss During Lactation in Female Mice by Inhibiting Osteocytic Osteolysis.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (9)  1 citation
    • Endonuclease-mediated (6) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amylin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcitonin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcitonin gene-related peptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcitonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcitonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcitonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amylin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cross-receptor inhibition within G protein-coupled receptor heterodimer ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mRNA stability IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of amylin receptor complex 1 ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of amylin receptor complex 2 ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of amylin receptor complex 3 ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcitonin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042725.1 → NP_001036190.1  calcitonin receptor isoform 1a precursor

      See identical proteins and their annotated locations for NP_001036190.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1a, previously called b), differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1b. The resulting isoform (1a, previously called b), has the same N- and C-termini but is shorter compared to isoform 1b.
      Source sequence(s)
      AC066688, AK133983
      Consensus CDS
      CCDS39416.1
      UniProtKB/TrEMBL
      Q924D6
      Related
      ENSMUSP00000130083.2, ENSMUST00000171613.8
      Conserved Domains (2) summary
      pfam02793
      Location:86 → 154
      HRM; Hormone receptor domain
      cd15274
      Location:162 → 425
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    2. NM_001355192.1 → NP_001342121.1  calcitonin receptor isoform 1a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1b. The resulting isoform (1a), has the same N- and C-termini but is shorter compared to isoform 1b. Variants 1a and 3 encode the same protein (isoform 1a).
      Source sequence(s)
      AK133983, AK138275, AK162391
      Consensus CDS
      CCDS39416.1
      UniProtKB/TrEMBL
      Q924D6
      Related
      ENSMUSP00000111285.2, ENSMUST00000115622.8
      Conserved Domains (2) summary
      pfam02793
      Location:86 → 154
      HRM; Hormone receptor domain
      cd15274
      Location:162 → 425
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

    3. NM_001377018.1 → NP_001363947.1  calcitonin receptor isoform 1b precursor

      Status: VALIDATED

      Source sequence(s)
      AC066688, AC161368
      UniProtKB/Swiss-Prot
      F6X7J4, Q3UUL9, Q60755, Q8CAB0
      UniProtKB/TrEMBL
      Q924D7
      Related
      ENSMUSP00000132124.3, ENSMUST00000170266.3
      Conserved Domains (2) summary
      cd15274
      Location:162 → 472
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:86 → 154
      HRM; Hormone receptor domain

    4. NM_007588.2 → NP_031614.2  calcitonin receptor isoform 1b precursor

      See identical proteins and their annotated locations for NP_031614.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1b), previously called a, represents the longer variant and encodes the longer isoform (1b, previously called a).
      Source sequence(s)
      AC066688, AK162391, CJ057218
      Consensus CDS
      CCDS39417.1
      UniProtKB/Swiss-Prot
      F6X7J4, Q3UUL9, Q60755, Q8CAB0
      UniProtKB/TrEMBL
      Q924D7
      Related
      ENSMUSP00000075070.7, ENSMUST00000075644.13
      Conserved Domains (2) summary
      cd15274
      Location:162 → 472
      7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
      pfam02793
      Location:86 → 154
      HRM; Hormone receptor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      3685678..3764713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60755.2 GenPept UniProtKB/Swiss-Prot:Q60755

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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