S100g S100 calcium binding protein G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S100gprovided by MGI
Official Full Name: S100 calcium binding protein Gprovided by MGI
Primary source: MGI:MGI:104528
See related: Ensembl:ENSMUSG00000040808 AllianceGenome:MGI:104528
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CABP1; Calb3; Cabp9k; CaBP-D9K
Summary: Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in extraembryonic component; gut; metanephros; and ureter. Orthologous to human S100G (S100 calcium binding protein G). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 553.0), kidney adult (RPKM 166.8) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F4; X 75.15 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (161744988..161747595, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (162961992..162964599, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mouse S100G protein exhibits properties characteristic of a calcium sensor.
Title: Mouse S100G protein exhibits properties characteristic of a calcium sensor.
Calbindin-D9k is a Novel Risk Gene for Neurodegenerative Disease.
Title: Calbindin-D(9k) is a Novel Risk Gene for Neurodegenerative Disease.
The results of this study show that CaBP-9k can protect pancreatic beta cell survival from ER stress and contribute to glucose homeostasis, which can reduce the risk of type 1 diabetes
Title: The Protective Role of Calbindin-D(9k) on Endoplasmic Reticulum Stress-Induced Beta Cell Death.
this paper show that S100Gmay be an important anti-inflammatory mediator in fibroblasts following colitis induction
Title: S100G expression and function in fibroblasts on colitis induction.
These findings suggest that expression of paracellular tight junction genes is regulated by transcellular CaBP proteins, suggesting that active and passive calcium transport pathways may function cooperatively
Title: Alteration of tight junction gene expression by calcium- and vitamin D-deficient diet in the duodenum of calbindin-null mice.
TRPV6, NCX1, and CaBP-9k in the fetal placenta and CaBP-28k in the maternal placenta may play key roles in controlling calcium transport across the placenta during pregnancy.
Title: Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D(9k) and -D(28k).
When immature mice were treated with 17beta-estradiol or progesterone for 3 days, we found that the expressions of Bax and caspase 3 protein were increased by estradiol treatment in WT and CaBP-9k KO mice.
Title: Apoptosis- and endoplasmic reticulum stress-related genes were regulated by estrogen and progesterone in the uteri of calbindin-D(9k) and -D(28k) knockout mice.
Ureteral obstruction leads to the alteration of renal vitamin D metabolic enzyme expression and calcium transporter abundance, which may secondarily induce the abnormality of vitamin D endocrine system and bone health.
Title: Changes of renal vitamin D metabolic enzyme expression and calcium transporter abundance in obstructive nephropathy.
These results indicate that deletion of CaBP-28k alone does not affect body calcium homeostasis, but that deletion of CaBP-9k and CaBP-28k has a significant effect on calcium processing under calcium-deficient conditions.
Title: Effect of dietary calcium and 1,25-(OH)2D3 on the expression of calcium transport genes in calbindin-D9k and -D28k double knockout mice.
PTHrP is an important regulator of fetal calcium homeostasis with its predominant effect being on unidirectional maternofetal transfer, probably mediated by modifying placental calbindin-D(9K) expression.
Title: Increased maternofetal calcium flux in parathyroid hormone-related protein-null mice.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

AU042539 (e-PCR)
- UniSTS:181350

AF028071 (e-PCR)
- UniSTS:160904

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info
enables vitamin D binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein S100-G

Names: CABP; calbindin 3, (vitamin D-dependent calcium binding protein); calbindin D9k; calbindin-D9K major form; cytidine 5'-triphosphate synthase 2; vitamin D-dependent calcium-binding protein, intestinal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009789.2 → NP_033919.1 protein S100-G

See identical proteins and their annotated locations for NP_033919.1

Status: VALIDATED

Source sequence(s)

AF293948

Consensus CDS

CCDS41203.1

UniProtKB/Swiss-Prot

P97816

UniProtKB/TrEMBL

Q5VM59, Q91XG5

Related

ENSMUSP00000045120.3, ENSMUST00000038769.3

Conserved Domains (2) summary

cd00213
Location:4 → 70

S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...

pfam13499
Location:10 → 74

EF-hand_7; EF-hand domain pair