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    Cacnb3 calcium channel, voltage-dependent, beta 3 subunit [ Mus musculus (house mouse) ]

    Gene ID: 12297, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cacnb3provided by MGI
    Official Full Name
    calcium channel, voltage-dependent, beta 3 subunitprovided by MGI
    Primary source
    MGI:MGI:103307
    See related
    Ensembl:ENSMUSG00000003352 AllianceGenome:MGI:103307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAB3; Beta3; Cchb3; Ca(v)beta3
    Summary
    Predicted to enable calcium channel regulator activity; high voltage-gated calcium channel activity; and protein kinase binding activity. Acts upstream of or within T cell receptor signaling pathway. Part of voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human CACNB3 (calcium voltage-gated channel auxiliary subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 57.2), CNS E18 (RPKM 51.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cacnb3 in Genome Data Viewer
    Location:
    15 F1; 15 54.64 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98526317..98542410)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98628436..98644536)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cyclin T1 Neighboring gene RIKEN cDNA 9330020H09 gene Neighboring gene STARR-positive B cell enhancer ABC_E1917 Neighboring gene sperm microtubule inner protein 11 Neighboring gene adenylate cyclase 6 Neighboring gene STARR-seq mESC enhancer starr_39665 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98440580-98440763 Neighboring gene STARR-positive B cell enhancer ABC_E9921 Neighboring gene STARR-seq mESC enhancer starr_39668 Neighboring gene DEAD box helicase 23 Neighboring gene STARR-positive B cell enhancer ABC_E8612 Neighboring gene STARR-positive B cell enhancer ABC_E9922 Neighboring gene Rho family GTPase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IP(3) Receptor-Dependent Cytoplasmic Ca(2+) Signals Are Tightly Controlled by Cavβ3. Belkacemi A, et al. Cell Rep, 2018 Jan 30. PMID 29386119
    2. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. Dilger EK, et al. J Neurosci, 2015 Feb 25. PMID 25716863, Free PMC Article
    3. Decreased calcium channel currents and facilitated epinephrine release in the Ca2+ channel beta3 subunit-null mice. Ohta T, et al. Biochem Biophys Res Commun, 2010 Apr 9. PMID 20144588
    4. Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels. Jha MK, et al. Nat Immunol, 2009 Dec. PMID 19838200, Free PMC Article
    5. Modified behavioral characteristics following ablation of the voltage-dependent calcium channel beta3 subunit. Murakami M, et al. Brain Res, 2007 Jul 30. PMID 17588550

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our results indicate that beta3, unrelated to its role as a Ca2+ channel subunit, specifically modulates the cell's IP3 sensitivity and thereby efficiently tunes agonist-induced cytoplasmic Ca2+ signals and cellular functions.
      Title: IP(3) Receptor-Dependent Cytoplasmic Ca(2+) Signals Are Tightly Controlled by Cavβ3.
    2. During development Cavbeta3 protein expression in the cerebellum peaks at postnatal days 15 and 21, and has diminished drastically by day 60, and in the hippocampus increases with age throughout all subfields.
      Title: Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brain.
    3. In transgenic mice lacking the calcium channel beta3 subunit, there are compensatory changes of calcium channel abundance leading to adaptation of alternate calcium transport mechanisms.
      Title: Impaired renal calcium absorption in mice lacking calcium channel beta 3 subunits.
    4. Differential gene expression analysis identifies murine Cacnb3 as strongly upregulated in distinct dendritic cell populations upon stimulation
      Title: Differential gene expression analysis identifies murine Cacnb3 as strongly upregulated in distinct dendritic cell populations upon stimulation.
    5. these results indicate the importance of the beta3 subunit in determining calcium channel characteristics and catecholamine release in adrenal chromaffin cells.
      Title: Decreased calcium channel currents and facilitated epinephrine release in the Ca2+ channel beta3 subunit-null mice.
    6. neither Ca(V)beta3 nor Ca(V)beta4 are indispensable for hair cell Ca(2+) currents but contribute to the overall current properties
      Title: Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4.
    7. Deficiency in beta3 regulatory subunit of voltage-gated calcium channels resulted in a profound survival defect of CD8(+) T cells.
      Title: Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels.
    8. These results suggest a possibility that, unrelated to voltage-dependent Ca(2+) channels regulation, Ca(v)beta3 negatively regulates the NMDAR activity in the hippocampus.
      Title: Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memory.
    9. Modified sympathetic nerve system activity with overexpression of the voltage-dependent calcium channel beta3 subunit.(
      Title: Modified sympathetic nerve system activity with overexpression of the voltage-dependent calcium channel beta3 subunit.
    10. Ca(V)beta(3) has only subtle effects on L-type Ca(2+) currents in ileum smooth muscle.
      Title: Ca2+ channel currents and contraction in CaVbeta3-deficient ileum smooth muscle from mouse.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to high voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables high voltage-gated calcium channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transmembrane transport via high voltage-gated calcium channel ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of detection of mechanical stimulus involved in sensory perception of touch ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane hyperpolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane repolarization during action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of L-type voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated calcium channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent L-type calcium channel subunit beta-3
    Names
    calcium channel voltage-dependent subunit beta 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044741.3 → NP_001038206.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156543
      Consensus CDS
      CCDS37192.1
      UniProtKB/TrEMBL
      D3Z3Z3, Q8K5A7
      Related
      ENSMUSP00000104778.2, ENSMUST00000109150.9
      Conserved Domains (4) summary
      cd12042
      Location:57 → 124
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:175 → 355
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:15 → 57
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:185 → 356
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. NM_001286226.2 → NP_001273155.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC156543
      Consensus CDS
      CCDS88834.1
      UniProtKB/TrEMBL
      A0A2U3TZ49, Q8K5A7
      Related
      ENSMUSP00000003442.9, ENSMUST00000003442.9
      Conserved Domains (4) summary
      cd12042
      Location:58 → 125
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:166 → 329
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:16 → 58
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:165 → 330
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    3. NM_001356543.2 → NP_001343472.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC156543
      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:57 → 124
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam12052
      Location:15 → 57
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:174 → 354
      Guanylate_kin; Guanylate kinase

    4. NM_001410382.1 → NP_001397311.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156543

    5. NM_001410383.1 → NP_001397312.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC156543

    6. NM_001410384.1 → NP_001397313.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC156543

    7. NM_007581.4 → NP_031607.2  voltage-dependent L-type calcium channel subunit beta-3 isoform 1

      See identical proteins and their annotated locations for NP_031607.2

      Status: VALIDATED

      Source sequence(s)
      AC156543
      Consensus CDS
      CCDS27800.1
      UniProtKB/Swiss-Prot
      G5E821, P54285
      UniProtKB/TrEMBL
      Q8K5A7
      Related
      ENSMUSP00000155514.2, ENSMUST00000230490.2
      Conserved Domains (3) summary
      cd12042
      Location:58 → 125
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:176 → 356
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:16 → 58
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    RNA

    1. NR_177064.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156543
      Related
      ENSMUST00000230064.2

    2. NR_177065.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156543

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98526317..98542410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316418.3 → XP_017171907.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X10

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:45 → 112
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:163 → 343
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:3 → 45
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    2. XM_006520365.2 → XP_006520428.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X10

      See identical proteins and their annotated locations for XP_006520428.1

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:45 → 112
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:163 → 343
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:3 → 45
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    3. XM_036159101.1 → XP_036014994.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X12

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:45 → 112
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:163 → 343
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:3 → 45
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    4. XM_030248302.2 → XP_030104162.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X1

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:58 → 125
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:176 → 356
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:16 → 58
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    5. XM_030248304.2 → XP_030104164.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X1

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:58 → 125
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:176 → 356
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:16 → 58
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    6. XM_006520367.2 → XP_006520430.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X13

      See identical proteins and their annotated locations for XP_006520430.1

      Conserved Domains (1) summary
      pfam00625
      Location:1 → 180
      Guanylate_kin; Guanylate kinase

    7. XM_017316415.3 → XP_017171904.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X1

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:58 → 125
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:176 → 356
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:16 → 58
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    8. XM_030248303.2 → XP_030104163.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X1

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:58 → 125
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:176 → 356
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:16 → 58
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    9. XM_036159097.1 → XP_036014990.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X5

      UniProtKB/Swiss-Prot
      G5E821, P54285
      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:58 → 125
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:176 → 356
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:16 → 58
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    10. XM_030248306.2 → XP_030104166.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X13

      Conserved Domains (1) summary
      pfam00625
      Location:1 → 180
      Guanylate_kin; Guanylate kinase

    11. XM_036159102.1 → XP_036014995.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X13

      Conserved Domains (1) summary
      pfam00625
      Location:1 → 180
      Guanylate_kin; Guanylate kinase

    12. XM_036159104.1 → XP_036014997.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X14

      Conserved Domains (1) summary
      pfam00625
      Location:1 → 180
      Guanylate_kin; Guanylate kinase

    13. XM_036159100.1 → XP_036014993.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X11

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:49 → 116
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:167 → 347
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:7 → 49
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    14. XM_006520361.4 → XP_006520424.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X3

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:58 → 125
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:175 → 355
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:16 → 58
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    15. XM_006520363.4 → XP_006520426.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X6

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:52 → 119
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:170 → 350
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:10 → 52
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    16. XM_006520364.4 → XP_006520427.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X8

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:49 → 116
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:167 → 347
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:7 → 49
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

    17. XM_036159106.1 → XP_036014999.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X15

      Conserved Domains (1) summary
      pfam00625
      Location:1 → 111
      Guanylate_kin; Guanylate kinase

    18. XM_030248305.2 → XP_030104165.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X13

      Conserved Domains (1) summary
      pfam00625
      Location:1 → 180
      Guanylate_kin; Guanylate kinase

    19. XM_036159103.1 → XP_036014996.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X14

      Conserved Domains (1) summary
      pfam00625
      Location:1 → 180
      Guanylate_kin; Guanylate kinase

    20. XM_036159099.1 → XP_036014992.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X9

      UniProtKB/TrEMBL
      Q8K5A7
      Conserved Domains (3) summary
      cd12042
      Location:52 → 119
      SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
      pfam00625
      Location:170 → 350
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:10 → 52
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54285.2 GenPept UniProtKB/Swiss-Prot:P54285

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