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    Btn1a1 butyrophilin, subfamily 1, member A1 [ Mus musculus (house mouse) ]

    Gene ID: 12231, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Btn1a1provided by MGI
    Official Full Name
    butyrophilin, subfamily 1, member A1provided by MGI
    Primary source
    MGI:MGI:103118
    See related
    Ensembl:ENSMUSG00000000706 AllianceGenome:MGI:103118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Btn
    Summary
    Predicted to enable signaling receptor binding activity. Involved in negative regulation of activated T cell proliferation and negative regulation of cytokine production. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in genitourinary system and heart valve. Orthologous to human BTN1A1 (butyrophilin subfamily 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in mammary gland adult (RPKM 3.3), liver E14.5 (RPKM 1.1) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A3.1; 13 9.72 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23641154..23650084, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23456984..23465914, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11534 Neighboring gene nuclear encoded tRNA threonine 6 (anticodon AGT) Neighboring gene STARR-positive B cell enhancer ABC_E11535 Neighboring gene nuclear encoded tRNA leucine 10 (anticodon CAG) Neighboring gene nuclear encoded tRNA glutamic acid 5 (anticodon TTC) Neighboring gene predicted gene, 52036 Neighboring gene nuclear encoded tRNA tyrosine 8 (anticodon GTA) Neighboring gene butyrophilin, subfamily 2, member A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets. Ogg SL, et al. Proc Natl Acad Sci U S A, 2004 Jul 6. PMID 15226505, Free PMC Article
    2. Structural organization and mammary-specific expression of the butyrophilin gene. Ogg SL, et al. Mamm Genome, 1996 Dec. PMID 8995761
    3. The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation. Jeong J, et al. FASEB Bioadv, 2021 Dec. PMID 34938960, Free PMC Article
    4. Restriction fragment length polymorphism in amplification products of the bovine butyrophilin gene: assignment of bovine butyrophilin to bovine chromosome 23. Taylor C, et al. Anim Genet, 1996 Jun. PMID 8759118
    5. Carboxy-terminal cytoplasmic domain of mouse butyrophilin specifically associates with a 150-kDa protein of mammary epithelial cells and milk fat globule membrane. Ishii T, et al. Biochim Biophys Acta, 1995 Dec 14. PMID 8541302

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data illustrated the importance of Akt1 in mammary epithelial cell proliferation, as well as in the regulation of Btn1a1 and subsequent expression of ss-casein.
      Title: Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1.
    2. These data are consistent with a coinhibitory role for mouse Butyrophilins
      Title: BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.
    3. PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase
      Title: The PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase: implications for the function of BTN1A1 in the mammary gland and other tissues.
    4. expression of Btn1a1 is essential for the regulated secretion of milk-lipid droplets.
      Title: Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of activated T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    butyrophilin subfamily 1 member A1
    Names
    BT

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013483.3 → NP_038511.1  butyrophilin subfamily 1 member A1 precursor

      See identical proteins and their annotated locations for NP_038511.1

      Status: VALIDATED

      Source sequence(s)
      AK142596, AK145168, AL714025, BE199598
      Consensus CDS
      CCDS26339.1
      UniProtKB/Swiss-Prot
      P97392, Q62556, Q8K2H7, Q921K7
      UniProtKB/TrEMBL
      Q3UM26, Q3UQC0
      Related
      ENSMUSP00000041013.8, ENSMUST00000041674.14
      Conserved Domains (3) summary
      smart00410
      Location:36 → 142
      IG_like; Immunoglobulin like
      cd15819
      Location:304 → 474
      SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)
      cl11960
      Location:44 → 143
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      23641154..23650084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516535.1 → XP_006516598.1  butyrophilin subfamily 1 member A1 isoform X1

      See identical proteins and their annotated locations for XP_006516598.1

      UniProtKB/TrEMBL
      Q3UM26
      Conserved Domains (2) summary
      cd15819
      Location:303 → 473
      SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)
      cl11960
      Location:43 → 142
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62556.2 GenPept UniProtKB/Swiss-Prot:Q62556

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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