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    Chic1 cysteine-rich hydrophobic domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 12212, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Chic1provided by MGI
    Official Full Name
    cysteine-rich hydrophobic domain 1provided by MGI
    Primary source
    MGI:MGI:1344694
    See related
    Ensembl:ENSMUSG00000031327 AllianceGenome:MGI:1344694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brx; Gm10454
    Summary
    Predicted to be located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including central nervous system; metanephros; and retina. Orthologous to human CHIC1 (cysteine rich hydrophobic domain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 3.3), cerebellum adult (RPKM 3.2) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X D; X 46.08 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (102400009..102452698)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (103356403..103409092)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47688 Neighboring gene caudal type homeobox 4 Neighboring gene predicted gene 9516 Neighboring gene testis specific X-linked gene Neighboring gene STARR-seq mESC enhancer starr_47691 Neighboring gene origin of replication in Tsix Neighboring gene X (inactive)-specific transcript, opposite strand Neighboring gene origin of replication in exon 1 of Xist Neighboring gene inactive X specific transcripts Neighboring gene predicted gene 14861

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5. Kino T, et al. Sci Signal, 2009 Feb 10. PMID 19211510, Free PMC Article
    2. Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system. Kino T, et al. J Biol Chem, 2006 Apr 7. PMID 16469733, Free PMC Article
    3. The region 3' to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene. Morey C, et al. EMBO J, 2004 Feb 11. PMID 14749728, Free PMC Article
    4. A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif. Cools J, et al. FEBS Lett, 2001 Mar 16. PMID 11257495
    5. Functional analysis of the DXPas34 locus, a 3' regulator of Xist expression. Debrand E, et al. Mol Cell Biol, 1999 Dec. PMID 10567576, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brx is essential for the expression of nfat5 in response to osmotic stress.
      Title: Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • B930075F07

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich hydrophobic domain-containing protein 1
    Names
    brain X-linked protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009767.3 → NP_033897.1  cysteine-rich hydrophobic domain-containing protein 1

      See identical proteins and their annotated locations for NP_033897.1

      Status: VALIDATED

      Source sequence(s)
      AL669964
      Consensus CDS
      CCDS53165.1
      UniProtKB/Swiss-Prot
      O08904, Q8CBW7, Q8K3S5
      UniProtKB/TrEMBL
      A2RT09, Q3UX08
      Related
      ENSMUSP00000112246.3, ENSMUST00000116547.3
      Conserved Domains (1) summary
      pfam10256
      Location:108 → 140
      Erf4; Golgin subfamily A member 7/ERF4 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      102400009..102452698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161794.1 → XP_036017687.1  cysteine-rich hydrophobic domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      pfam10256
      Location:108 → 140
      Erf4; Golgin subfamily A member 7/ERF4 family

    2. XM_006527760.5 → XP_006527823.1  cysteine-rich hydrophobic domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      Q3UX08
      Conserved Domains (1) summary
      pfam10256
      Location:108 → 140
      Erf4; Golgin subfamily A member 7/ERF4 family

    3. XM_036161795.1 → XP_036017688.1  cysteine-rich hydrophobic domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam10256
      Location:108 → 140
      Erf4; Golgin subfamily A member 7/ERF4 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CBW7.2 GenPept UniProtKB/Swiss-Prot:Q8CBW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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