Bmpr1b bone morphogenetic protein receptor, type 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bmpr1bprovided by MGI
Official Full Name: bone morphogenetic protein receptor, type 1Bprovided by MGI
Primary source: MGI:MGI:107191
See related: Ensembl:ENSMUSG00000052430 AllianceGenome:MGI:107191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Alk6; SKR6; ALK-6; Acvrlk6; BMPR-1B; BMPR-IB; CFK-43a
Summary: This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Expression: Biased expression in limb E14.5 (RPKM 1.8), frontal lobe adult (RPKM 1.8) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H1; 3 66.11 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (141540230..141875335, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (141837135..142169585, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bone morphogenetic protein signaling through the Bmpr1a and Bmpr1b regulates the development of the hindbrain.
Title: Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip.
Study concludes that growth/differentiation factor-5 (GDF-5) protects hippocampal neurons against kainic acid-induced neurodegeneration by signaling through bone morphogenetic protein receptor type IB, suggesting a therapeutic potential for GDF-5 in neurodegenerative diseases.
Title: Signaling by growth/differentiation factor 5 through the bone morphogenetic protein receptor type IB protects neurons against kainic acid-induced neurodegeneration.
dermal BMPRIB+ cells possessed a similar osteogenic differentiation potential with BMSCs in a mouse model. Dermal BMPRIB+ subpopulations possessed low immunogenicity and immunosuppressive properties before and after osteogenic differentiation.
Title: The Immunologic Properties of Bone Morphogenic Protein Receptor IB Positive Subpopulation before and after Osteogenic Differentiation in Mouse Dermis.
BMPR1B plays distinct roles from BMPR1A and ACVR1 in maintaining bone mass and transducing BMP signaling
Title: Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors.
This study demonistrated that BMP signaling has no major role in the development of excitatory and inhibitory synapses in the lateral superior olive.
Title: BMP signaling specifies the development of a large and fast CNS synapse.
Local administration of adenovirus expressing siRNA-targeting BMPR-IB may be a feasible and effective therapeutic candidate to treat or prevent wear debris-associated osteolysis.
Title: Inhibitory effect of adenovirus-mediated siRNA-targeting BMPR-IB on UHMWPE-induced bone destruction in the murine air pouch model.
Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity
Title: Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity.
the BMP-2-BMPR-IB-ODAM-MAPK signaling cascade has important roles in ameloblast differentiation and enamel mineralization
Title: Odontogenic ameloblasts-associated protein (ODAM), via phosphorylation by bone morphogenetic protein receptor type IB (BMPR-IB), is implicated in ameloblast differentiation.
Variation in BMPR1B is associated with dizygotic twinning.
Title: Variation in BMPR1B, TGFRB1 and BMPR2 and control of dizygotic twinning.
signaling through BMPR1A;B performs at least two roles in early respiratory development: first, it promotes tracheal formation through repression of Sox2; and second, it restricts the site of lung bud initiation.
Title: Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Transposon induced (1) 1 citation
Targeted (2) 1 citation
Not Applicable (1) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa88g6.seq (e-PCR)
- UniSTS:125441

Bmpr1b (e-PCR), detects polymorphism
- UniSTS:496648

MARC_8975-8976:1025019065:3 (e-PCR)
- UniSTS:531260

Bmpr1b (e-PCR), detects polymorphism
- UniSTS:480336

Bmpr1b (e-PCR), detects polymorphism
- UniSTS:158678

Bmpr1b (e-PCR), detects polymorphism
- UniSTS:158679

AI385617 (e-PCR)
- UniSTS:159196

Z23143 (e-PCR)
- UniSTS:125921

AV355320 (e-PCR)
- UniSTS:178943

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables BMP binding	IDA Inferred from Direct Assay more info	PubMed
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables BMP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables BMP receptor activity	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity	TAS Traceable Author Statement more info	PubMed
enables transforming growth factor beta receptor activity, type I	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta receptor activity, type I	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane receptor protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage condensation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within central nervous system neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chondrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in estrogen biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IEP Inferred from Expression Pattern more info	PubMed
involved_in osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in ovarian cumulus expansion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bone morphogenetic protein receptor type-1B

Names: BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine-protein kinase receptor R6

NP_001264145.1

EC 2.7.11.30

NP_001264146.1

EC 2.7.11.30

NP_001264147.1

EC 2.7.11.30

NP_001264149.1

EC 2.7.11.30

NP_001341972.1

EC 2.7.11.30

NP_031586.1

EC 2.7.11.30

XP_006501002.1

EC 2.7.11.30

XP_006501003.1

EC 2.7.11.30

XP_006501005.1

EC 2.7.11.30

XP_006501006.1

EC 2.7.11.30

XP_030108258.1

EC 2.7.11.30

XP_036018761.1

EC 2.7.11.30

XP_036018762.1

EC 2.7.11.30

XP_036018763.1

EC 2.7.11.30

XP_036018764.1

EC 2.7.11.30

XP_036018765.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277216.3 → NP_001264145.1 bone morphogenetic protein receptor type-1B isoform a precursor

See identical proteins and their annotated locations for NP_001264145.1

Status: VALIDATED

Source sequence(s)

AC139128, AC157492, AC161533

Consensus CDS

CCDS17874.1

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4

Related

ENSMUSP00000096167.2, ENSMUST00000098568.8

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
NM_001277217.3 → NP_001264146.1 bone morphogenetic protein receptor type-1B isoform a precursor

See identical proteins and their annotated locations for NP_001264146.1

Status: VALIDATED

Source sequence(s)

AC139128, AC157492

Consensus CDS

CCDS17874.1

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4

Related

ENSMUSP00000101837.2, ENSMUST00000106230.2

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
NM_001277218.2 → NP_001264147.1 bone morphogenetic protein receptor type-1B isoform a precursor

See identical proteins and their annotated locations for NP_001264147.1

Status: VALIDATED

Source sequence(s)

AC157492

Consensus CDS

CCDS17874.1

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4

Related

ENSMUSP00000101839.2, ENSMUST00000106232.8

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
NM_001277220.2 → NP_001264149.1 bone morphogenetic protein receptor type-1B isoform b

See identical proteins and their annotated locations for NP_001264149.1

Status: VALIDATED

Source sequence(s)

AC157492

UniProtKB/TrEMBL

Q3USS1

Conserved Domains (3) summary

smart00220
Location:194 → 478

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14219
Location:187 → 491

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:31 → 99

Activin_recp; Activin types I and II receptor domain
NM_001355043.2 → NP_001341972.1 bone morphogenetic protein receptor type-1B isoform a precursor

Status: VALIDATED

Source sequence(s)

AC157492

Consensus CDS

CCDS17874.1

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
NM_001428393.1 → NP_001415322.1 bone morphogenetic protein receptor type-1B isoform a precursor

Status: VALIDATED

Source sequence(s)

AC139128, AC157492, AC161533

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4
NM_001428394.1 → NP_001415323.1 bone morphogenetic protein receptor type-1B isoform a precursor

Status: VALIDATED

Source sequence(s)

AC139128, AC157492

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4
NM_001428395.1 → NP_001415324.1 bone morphogenetic protein receptor type-1B isoform a precursor

Status: VALIDATED

Source sequence(s)

AC139128, AC157492, AC161533

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4
NM_001428396.1 → NP_001415325.1 bone morphogenetic protein receptor type-1B isoform a precursor

Status: VALIDATED

Source sequence(s)

AC139128, AC157492

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4
NM_001428397.1 → NP_001415326.1 bone morphogenetic protein receptor type-1B isoform a precursor

Status: VALIDATED

Source sequence(s)

AC139128, AC157492, AC161533

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4
NM_001428398.1 → NP_001415327.1 bone morphogenetic protein receptor type-1B isoform a precursor

Status: VALIDATED

Source sequence(s)

AC157492

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4
NM_007560.5 → NP_031586.1 bone morphogenetic protein receptor type-1B isoform a precursor

See identical proteins and their annotated locations for NP_031586.1

Status: VALIDATED

Source sequence(s)

AC157492

Consensus CDS

CCDS17874.1

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4

Related

ENSMUSP00000029948.8, ENSMUST00000029948.15

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

141540230..141875335 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162871.1 → XP_036018764.1 bone morphogenetic protein receptor type-1B isoform X1

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_036162870.1 → XP_036018763.1 bone morphogenetic protein receptor type-1B isoform X1

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_006500940.5 → XP_006501003.1 bone morphogenetic protein receptor type-1B isoform X1

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_006500942.3 → XP_006501005.1 bone morphogenetic protein receptor type-1B isoform X1

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_006500939.5 → XP_006501002.1 bone morphogenetic protein receptor type-1B isoform X1

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_036162869.1 → XP_036018762.1 bone morphogenetic protein receptor type-1B isoform X1

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_030252398.2 → XP_030108258.1 bone morphogenetic protein receptor type-1B isoform X1

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_036162868.1 → XP_036018761.1 bone morphogenetic protein receptor type-1B isoform X1

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_006500943.5 → XP_006501006.1 bone morphogenetic protein receptor type-1B isoform X1

See identical proteins and their annotated locations for XP_006501006.1

UniProtKB/Swiss-Prot

P36898, Q3TRF2

UniProtKB/TrEMBL

B2RRZ4

Conserved Domains (2) summary

cd14219
Location:198 → 502

STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB

pfam01064
Location:34 → 106

Activin_recp; Activin types I and II receptor domain
XM_036162872.1 → XP_036018765.1 bone morphogenetic protein receptor type-1B isoform X2

Conserved Domains (1) summary

cd14144
Location:3 → 289

STKc_BMPR1; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor