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    Bet1 Bet1 golgi vesicular membrane trafficking protein [ Mus musculus (house mouse) ]

    Gene ID: 12068, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Bet1provided by MGI
    Official Full Name
    Bet1 golgi vesicular membrane trafficking proteinprovided by MGI
    Primary source
    MGI:MGI:1343104
    See related
    Ensembl:ENSMUSG00000032757 AllianceGenome:MGI:1343104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bet-1
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Predicted to act upstream of or within vesicle-mediated transport. Located in Golgi membrane. Orthologous to human BET1 (Bet1 golgi vesicular membrane trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 9.5), liver E18 (RPKM 9.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A1; 6 1.81 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (4076899..4086930, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (4076899..4086998, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930528H21 gene Neighboring gene guanine nucleotide binding protein (G protein), gamma 11 Neighboring gene STARR-positive B cell enhancer ABC_E11732 Neighboring gene STARR-seq mESC enhancer starr_15007 Neighboring gene STARR-seq mESC enhancer starr_15008 Neighboring gene STARR-seq mESC enhancer starr_15009 Neighboring gene STARR-seq mESC enhancer starr_15010 Neighboring gene 60S acidic ribosomal protein P1-like Neighboring gene KH-type splicing regulatory protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus. Zhang T, et al. J Cell Biol, 1997 Dec 1. PMID 9382863, Free PMC Article
    2. Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport. Zhang T, et al. J Biol Chem, 2001 Jul 20. PMID 11323436
    3. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus. Loh E, et al. J Cell Sci, 2005 Mar 15. PMID 15728249
    4. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Hay JC, et al. Cell, 1997 Apr 4. PMID 9094723
    5. Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. Ono R, et al. Nat Genet, 2006 Jan. PMID 16341224

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cis cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BET1 homolog
    Names
    blocked early in transport 1 homolog
    golgi vesicular membrane-trafficking protein p18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009748.3 → NP_033878.1  BET1 homolog

      See identical proteins and their annotated locations for NP_033878.1

      Status: VALIDATED

      Source sequence(s)
      AC022235, AI429387, AK078796, AV003506, DV052674
      Consensus CDS
      CCDS19895.1
      UniProtKB/Swiss-Prot
      O35623
      UniProtKB/TrEMBL
      Q8BNZ1
      Related
      ENSMUSP00000044877.5, ENSMUST00000049166.5
      Conserved Domains (1) summary
      cd15853
      Location:29 → 87
      SNARE_Bet1; SNARE motif of Bet1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      4076899..4086930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35623.1 GenPept UniProtKB/Swiss-Prot:O35623

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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