Bdkrb2 bradykinin receptor, beta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bdkrb2provided by MGI
Official Full Name: bradykinin receptor, beta 2provided by MGI
Primary source: MGI:MGI:102845
See related: Ensembl:ENSMUSG00000021070 AllianceGenome:MGI:102845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B2; B2R; BK2; B(2); BK-2; BK2R; BKR2; BRB2
Summary: Predicted to enable several functions, including G protein-coupled receptor binding activity; bradykinin receptor activity; and protein heterodimerization activity. Acts upstream of or within several processes, including negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator; negative regulation of peptidyl-serine phosphorylation; and vasodilation. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in plasma membrane. Is expressed in collecting duct and metanephros. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (bradykinin receptor B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 5.2), subcutaneous fat pad adult (RPKM 3.2) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 E; 12 55.76 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (105529431..105561503)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (105563172..105595244)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Bradykinin B2 Receptor Ablation from Tyrosine Hydroxylase Cells on Behavioral and Motor Aspects in Male and Female Mice.
Title: Effects of Bradykinin B2 Receptor Ablation from Tyrosine Hydroxylase Cells on Behavioral and Motor Aspects in Male and Female Mice.
Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors.
Title: Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors.
In vivo near-infrared fluorescence and SPECT-CT imaging of colorectal Cancer using the bradykinin B2R-specific ligand icatibant.
Title: In vivo near-infrared fluorescence and SPECT-CT imaging of colorectal Cancer using the bradykinin B2R-specific ligand icatibant.
Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model.
Title: Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model.
Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists.
Title: Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists.
the present work reveals to date no functions described for the B2 receptor in muscle regeneration due to the control of proliferation and differentiation of muscle precursor cells.
Title: Kinin-B2 Receptor Activity in Skeletal Muscle Regeneration and Myoblast Differentiation.
These findings suggested that miR-204-3p may play a protective role in high glucose-induced apoptosis and dysfunction in podocytes through down-regulation of Bdkrb2.
Title: MicroRNA-204-3p Attenuates High Glucose-Induced MPC5 Podocytes Apoptosis by Targeting Braykinin B2 Receptor.
it was also demonstrated that B1R knockout mice infected presented a significant reduction of survival. However, the infection did not alter the B2R levels and localization in liver blood vessels
Title: Malaria infection promotes a selective expression of kinin receptors in murine liver.
B1- and B2-kinin receptors govern Reactive Oxygen Species generation, while disruption of B1- and B2-kinin receptors leads to impaired cardiac dysfunction through excessive tyrosine nitration on the SERCA2 structure.
Title: Ablation of B(1)- and B(2)-kinin receptors causes cardiac dysfunction through redox-nitroso unbalance.
Bradykinin B2 receptor is necessary on the cellular level to induce cell proliferation and fate choice toward a neuronal lineage after physical exercise.
Title: Bradykinin B2 receptor is essential to running-induced cell proliferation in the adult mouse hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (84)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

PMC150944P1 (e-PCR)
- UniSTS:271125

PMC150945P1 (e-PCR)
- UniSTS:271126

NoName (e-PCR)
- UniSTS:491297

RH94464 (e-PCR)
- UniSTS:119712

L27595 (e-PCR)
- UniSTS:124891

X78438 (e-PCR)
- UniSTS:180466

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables beta-2 adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables bradykinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables bradykinin receptor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables type 1 angiotensin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in acute inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to salt stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B2 bradykinin receptor

Names: BK-2 receptor; kinin B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009747.2 → NP_033877.3 B2 bradykinin receptor

See identical proteins and their annotated locations for NP_033877.3

Status: VALIDATED

Source sequence(s)

AC068459

Consensus CDS

CCDS49160.1

UniProtKB/Swiss-Prot

B9EHE3, P32299

UniProtKB/TrEMBL

B2RQ47

Related

ENSMUSP00000001652.6, ENSMUST00000001652.7

Conserved Domains (1) summary

cd15381
Location:60 → 344

7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

105529431..105561503

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243991.4 → XP_011242293.1 B2 bradykinin receptor isoform X1

UniProtKB/TrEMBL

B2RQ47

Conserved Domains (1) summary

cd15381
Location:74 → 358

7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006515442.5 → XP_006515505.1 B2 bradykinin receptor isoform X2

See identical proteins and their annotated locations for XP_006515505.1

UniProtKB/Swiss-Prot

B9EHE3, P32299

UniProtKB/TrEMBL

B2RQ47

Conserved Domains (1) summary

cd15381
Location:60 → 344

7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036157172.1 → XP_036013065.1 B2 bradykinin receptor isoform X1

UniProtKB/TrEMBL

B2RQ47

Conserved Domains (1) summary

cd15381
Location:74 → 358

7tmA_BK-2; bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors