Bdkrb1 bradykinin receptor, beta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bdkrb1provided by MGI
Official Full Name: bradykinin receptor, beta 1provided by MGI
Primary source: MGI:MGI:88144
See related: Ensembl:ENSMUSG00000041347 AllianceGenome:MGI:88144
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B1R; BKR1; B1BKR; Bdkrb; BRADYB1
Summary: Enables peptide binding activity. Acts upstream of or within response to lipopolysaccharide. Predicted to be located in membrane and neuron projection. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Orthologous to human BDKRB1 (bradykinin receptor B1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 12 E; 12 55.81 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (105570350..105571770)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (105604091..105605511)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors.
Title: Kinin receptors regulate skeletal muscle regeneration: differential effects for B1 and B2 receptors.
Kinin B1 receptor deficiency protects mice fed by cafeteria diet from abnormal glucose homeostasis.
Title: Kinin B1 receptor deficiency protects mice fed by cafeteria diet from abnormal glucose homeostasis.
Blockade of the kinin B1 receptor counteracts the depressive-like behaviour and mechanical allodynia in ovariectomised mice.
Title: Blockade of the kinin B(1) receptor counteracts the depressive-like behaviour and mechanical allodynia in ovariectomised mice.
Hypothalamic kinin B1 receptor mediates orexin system hyperactivity in neurogenic hypertension.
Title: Hypothalamic kinin B1 receptor mediates orexin system hyperactivity in neurogenic hypertension.
Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model.
Title: Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model.
Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists.
Title: Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists.
Kinin B1 Receptor Is Important in the Pathogenesis of Myeloperoxidase-Specific ANCA GN.
Title: Kinin B1 Receptor Is Important in the Pathogenesis of Myeloperoxidase-Specific ANCA GN.
it was also demonstrated that B1R knockout mice infected presented a significant reduction of survival. However, the infection did not alter the B2R levels and localization in liver blood vessels
Title: Malaria infection promotes a selective expression of kinin receptors in murine liver.
B1R exerts a pivotal role in the development of Trichloroethylene induced liver injury.
Title: Role of selective blocking of bradykinin B1 receptor in attenuating immune liver injury in trichloroethylene-sensitized mice.
B1- and B2-kinin receptors govern Reactive Oxygen Species generation, while disruption of B1- and B2-kinin receptors leads to impaired cardiac dysfunction through excessive tyrosine nitration on the SERCA2 structure.
Title: Ablation of B(1)- and B(2)-kinin receptors causes cardiac dysfunction through redox-nitroso unbalance.

Submit: New GeneRIF Correction See all GeneRIFs (85)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

UniSTS:495960 (e-PCR)
- UniSTS:495960

Bdkrb1 (e-PCR), detects polymorphism
- UniSTS:495960

NoName (e-PCR)
- UniSTS:491211

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables bradykinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables bradykinin receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: B1 bradykinin receptor

Names: BK-1 receptor; kinin B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.