Axin1 axin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Axin1provided by MGI
Official Full Name: axin 1provided by MGI
Primary source: MGI:MGI:1096327
See related: Ensembl:ENSMUSG00000024182 AllianceGenome:MGI:1096327
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fu; Kb; Ki; Axin; fused; kinky; knobbly
Summary: Enables several functions, including SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in positive regulation of JNK cascade; positive regulation of protein modification process; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of macromolecule metabolic process; and regulation of protein metabolic process. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and microtubule cytoskeleton. Part of Wnt signalosome and beta-catenin destruction complex. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human AXIN1 (axin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 11.6), CNS E11.5 (RPKM 10.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 13.07 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (26350294..26414784)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (26131217..26195811)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAF2 decrease promotes the TGF-beta-mTORC1 signal in MAFLD-HCC through enhancing AXIN1-mediated Smad7 degradation.
Title: TRAF2 decrease promotes the TGF-β-mTORC1 signal in MAFLD-HCC through enhancing AXIN1-mediated Smad7 degradation.
Axin1's mystique in manipulating microbiome amidst colitis.
Title: Axin1's mystique in manipulating microbiome amidst colitis.
RSK2 inactivation cooperates with AXIN1 inactivation or beta-catenin activation to promote hepatocarcinogenesis.
Title: RSK2 inactivation cooperates with AXIN1 inactivation or β-catenin activation to promote hepatocarcinogenesis.
Axin1 Protects Colon Carcinogenesis by an Immune-Mediated Effect.
Title: Axin1 Protects Colon Carcinogenesis by an Immune-Mediated Effect.
Specific deletion of Axin1 leads to activation of beta-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice.
Title: Specific deletion of Axin1 leads to activation of β-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice.
Axin1: A novel scaffold protein joins the antiviral network of interferon.
Title: Axin1: A novel scaffold protein joins the antiviral network of interferon.
AXIN1 knockout does not alter AMPK/mTORC1 regulation and glucose metabolism in mouse skeletal muscle.
Title: AXIN1 knockout does not alter AMPK/mTORC1 regulation and glucose metabolism in mouse skeletal muscle.
HIF-1alpha/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt/beta-catenin signaling pathway in Parkinson's disease models.
Title: HIF-1α/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt/β-catenin signaling pathway in Parkinson's disease models.
siRNA-mediated Axin1 knockdown lessened activation of AMPK in contracted myotubes
Title: An AMPK/Axin1-Rac1 signaling pathway mediates contraction-regulated glucose uptake in skeletal muscle cells.
loss of Axin1 cooperates with c-Met to induce hepatocellular carcinoma in mice, in a beta-Catenin signaling-dependent but Notch cascade-independent way.
Title: Axis inhibition protein 1 (Axin1) Deletion-Induced Hepatocarcinogenesis Requires Intact β-Catenin but Not Notch Cascade in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (3) 1 citation
Transgenic (1) 1 citation
Targeted (8) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC134648P1 (e-PCR)
- UniSTS:270734

D17Mit100 (e-PCR), detects polymorphism
- UniSTS:116641

Axin1 (e-PCR), detects polymorphism
- UniSTS:527270

RH136120 (e-PCR)
- UniSTS:210115

RH44784 (e-PCR)
- UniSTS:28633

AF009011 (e-PCR)
- UniSTS:180980

AI661267 (e-PCR)
- UniSTS:180981

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables I-SMAD binding	IDA Inferred from Direct Assay more info	PubMed
enables I-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables I-SMAD binding	ISO Inferred from Sequence Orthology more info
enables R-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axial mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axial mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytoplasmic microtubule organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral axis specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal/ventral axis specification	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within embryonic skeletal joint morphogenesis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within epigenetic programming in the zygotic pronuclei	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte homeostasis	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within head development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemoglobin metabolic process	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system process	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within nucleocytoplasmic transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein ubiquitination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of Wnt signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin destruction complex	IDA Inferred from Direct Assay more info	PubMed
part_of beta-catenin destruction complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	NAS Non-traceable Author Statement more info	PubMed
part_of beta-catenin destruction complex	TAS Traceable Author Statement more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: axin-1

Names: axis inhibition protein 1; protein Fused

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159598.2 → NP_001153070.2 axin-1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).

Source sequence(s)

AC126438, AC140047

Consensus CDS

CCDS50042.1

UniProtKB/TrEMBL

Q14DJ8

Related

ENSMUSP00001091662.1, ENSMUST00020183805.1

Conserved Domains (3) summary

cd08707
Location:89 → 209

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:745 → 827

DAX; Domain present in Dishevelled and axin

cd11582
Location:11 → 80

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
NM_001394381.1 → NP_001381310.1 axin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC126438, AC140047

UniProtKB/Swiss-Prot

O35625

UniProtKB/TrEMBL

E9QMJ8

Conserved Domains (4) summary

cd08707
Location:89 → 209

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:781 → 863

DAX; Domain present in Dishevelled and axin

cd11582
Location:11 → 80

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam08833
Location:464 → 495

Axin_b-cat_bind; Axin beta-catenin binding domain
NM_001394382.1 → NP_001381311.1 axin-1 isoform 1

Status: VALIDATED

Source sequence(s)

AC126438, AC140047

UniProtKB/TrEMBL

Q14DJ8

Conserved Domains (3) summary

cd08707
Location:89 → 209

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:745 → 827

DAX; Domain present in Dishevelled and axin

cd11582
Location:11 → 80

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
NM_001394389.1 → NP_001381318.1 axin-1 isoform 1

Status: VALIDATED

Source sequence(s)

AC126438, AC140047

UniProtKB/TrEMBL

Q14DJ8

Conserved Domains (3) summary

cd08707
Location:89 → 209

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:745 → 827

DAX; Domain present in Dishevelled and axin

cd11582
Location:11 → 80

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
NM_009733.3 → NP_033863.3 axin-1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region compared to variant 1, resulting in a longer protein (isoform 2) compared to isoform 1.

Source sequence(s)

AC126438, AC140047

Consensus CDS

CCDS28547.2

UniProtKB/Swiss-Prot

O35625

UniProtKB/TrEMBL

E9QMJ8

Related

ENSMUSP00000073974.5, ENSMUST00000074370.11

Conserved Domains (4) summary

cd08707
Location:89 → 209

RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein

smart00021
Location:781 → 863

DAX; Domain present in Dishevelled and axin

cd11582
Location:11 → 80

Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin

pfam08833
Location:464 → 495

Axin_b-cat_bind; Axin beta-catenin binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

26350294..26414784

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523516.3 → XP_006523579.1 axin-1 isoform X3

UniProtKB/TrEMBL

Q7TMI9

Conserved Domains (2) summary

pfam00778
Location:428 → 503

DIX; DIX domain

pfam08833
Location:108 → 161

Axin_b-cat_bind; Axin beta-catenin binding domain