Hnrnpd heterogeneous nuclear ribonucleoprotein D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hnrnpdprovided by MGI
Official Full Name: heterogeneous nuclear ribonucleoprotein Dprovided by MGI
Primary source: MGI:MGI:101947
See related: Ensembl:ENSMUSG00000000568 AllianceGenome:MGI:101947
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Auf1; Hnrpd
Summary: Predicted to enable chromatin binding activity; histone deacetylase binding activity; and nucleic acid binding activity. Involved in mRNA transcription by RNA polymerase II and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within regulation of mRNA stability. Located in synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human HNRNPD (heterogeneous nuclear ribonucleoprotein D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 36.7), CNS E14 (RPKM 24.3) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E4; 5 48.46 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (100103794..100126926, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (99955935..99979130, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts.
Title: RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts.
AUF-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through AUF-1-Dicer-1-mir-122 hierarchy.
Title: AUF-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through AUF-1-Dicer-1-mir-122 hierarchy.
AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3.
Title: AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3.
AUF1, an mRNA decay factor, has a discordant role in Cpeb1 expression.
Title: AUF1, an mRNA decay factor, has a discordant role in Cpeb1 expression.
AUF1 therefore orchestrates muscle stem cell proliferation, self-renewal, myoblast differentiation, and ultimately formation of muscle fibers through targeted, staged mRNA decay.
Title: Muscle development and regeneration controlled by AUF1-mediated stage-specific degradation of fate-determining checkpoint mRNAs.
In this study, AUF1, was posttranslationally destabilized to bring about activation of BMP signaling and wound healing during Candida albicans infection
Title: Deregulated AUF1 Assists BMP-EZH2-Mediated Delayed Wound Healing during Candida albicans Infection.
Study identified RANKL and BCL6 mRNA as targets of AUF1 p42. Detailed analysis of 3'UTRs revealed for both that full instability required two elements, which are conserved in evolution. In RANKL mRNA both elements are AU-rich and separated by 30 bases, while in BCL6 mRNA one is AU-rich and 60 bases from a non-AU-rich element that potentially forms a stem-loop structure.
Title: Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each.
Control of ARE-mRNA decay by AUF1 represents a mechanism for adult stem cell regulation.
Title: Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity.
These results suggest that the post-transcriptional regulation of ATX expression by HuR and AUF1 modulates cancer cell migration.
Title: Autotaxin Expression Is Regulated at the Post-transcriptional Level by the RNA-binding Proteins HuR and AUF1.
MEF2C is a key effector of the myogenesis program promoted by AUF1.
Title: RNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hnrnpd (e-PCR), detects polymorphism
- UniSTS:516706

Hnrnpd (e-PCR), detects polymorphism
- UniSTS:516707

Hnrnpd (e-PCR), detects polymorphism
- UniSTS:516708

Hnrpd (e-PCR), detects polymorphism
- UniSTS:479121

RH136938 (e-PCR)
- UniSTS:219027

MARC_23646-23647:1029444341:1 (e-PCR)
- UniSTS:268733

MARC_23648-23649:1029444924:1 (e-PCR)
- UniSTS:268734

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables minor groove of adenine-thymine-rich DNA binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables telomeric DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in CRD-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nitric oxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to putrescine	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomerase RNA reverse transcriptase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of mRNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to rapamycin	ISO Inferred from Sequence Orthology more info
involved_in response to sodium phosphate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of mCRD-mediated mRNA stability complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein D0

Names: AU-rich element RNA-binding protein 1; hnRNP D0

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077265.2 → NP_001070733.1 heterogeneous nuclear ribonucleoprotein D0 isoform a

See identical proteins and their annotated locations for NP_001070733.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC022062, BC049098, CX567003

Consensus CDS

CCDS39182.1

UniProtKB/Swiss-Prot

Q60667, Q60668, Q80ZJ0, Q91X94

Related

ENSMUSP00000132735.2, ENSMUST00000172361.8

Conserved Domains (3) summary

cd12575
Location:99 → 172

RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins

cd12583
Location:183 → 257

RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain
NM_001077266.2 → NP_001070734.1 heterogeneous nuclear ribonucleoprotein D0 isoform b

See identical proteins and their annotated locations for NP_001070734.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.

Source sequence(s)

AC022062, AK077409, BC049098, CA451481, CK618758

Consensus CDS

CCDS39180.1

UniProtKB/TrEMBL

G3X9W0

Related

ENSMUSP00000108561.4, ENSMUST00000112939.10

Conserved Domains (3) summary

cd12583
Location:164 → 238

RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain

cd12756
Location:80 → 153

RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
NM_001077267.2 → NP_001070735.1 heterogeneous nuclear ribonucleoprotein D0 isoform d

See identical proteins and their annotated locations for NP_001070735.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons, one each in the 5' and the 3' coding regions, compared to variant 1. It encodes isoform d, which is shorter than isoform a.

Source sequence(s)

AC022062, BC049098, CF751545, CK618758

Consensus CDS

CCDS51571.1

UniProtKB/TrEMBL

G5E8G0

Related

ENSMUSP00000072533.7, ENSMUST00000072750.13

Conserved Domains (3) summary

cd12583
Location:164 → 238

RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain

cd12756
Location:80 → 153

RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
NM_007516.3 → NP_031542.2 heterogeneous nuclear ribonucleoprotein D0 isoform c

See identical proteins and their annotated locations for NP_031542.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform c, which lacks an internal segment and is shorter, compared to isoform a.

Source sequence(s)

AC022062, BC049098

Consensus CDS

CCDS39181.1

UniProtKB/Swiss-Prot

Q60668

Related

ENSMUSP00000019128.9, ENSMUST00000019128.15

Conserved Domains (3) summary

cd12583
Location:183 → 257

RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain

cd12756
Location:99 → 172

RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

100103794..100126926 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164755.1 → XP_036020648.1 heterogeneous nuclear ribonucleoprotein D0 isoform X4

UniProtKB/TrEMBL

G5E8G0

Conserved Domains (3) summary

cd12583
Location:164 → 238

RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain

cd12756
Location:80 → 153

RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
XM_036164753.1 → XP_036020646.1 heterogeneous nuclear ribonucleoprotein D0 isoform X2

UniProtKB/TrEMBL

G3X9W0

Conserved Domains (3) summary

cd12583
Location:164 → 238

RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain

cd12756
Location:80 → 153

RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
XM_036164754.1 → XP_036020647.1 heterogeneous nuclear ribonucleoprotein D0 isoform X3

Conserved Domains (3) summary

cd12583
Location:183 → 257

RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain

cd12756
Location:99 → 172

RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
XM_006534735.5 → XP_006534798.1 heterogeneous nuclear ribonucleoprotein D0 isoform X1

See identical proteins and their annotated locations for XP_006534798.1

UniProtKB/Swiss-Prot

Q60667, Q60668, Q80ZJ0, Q91X94

Conserved Domains (3) summary

cd12575
Location:99 → 172

RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins

cd12583
Location:183 → 257

RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

pfam08143
Location:60 → 78

CBFNT; CBFNT (NUC161) domain
XM_036164756.1 → XP_036020649.1 heterogeneous nuclear ribonucleoprotein D0 isoform X5

UniProtKB/TrEMBL

F6ZV59

Conserved Domains (2) summary

cd12583
Location:85 → 159

RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

cd12756
Location:1 → 74

RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins