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    Atp5mc1 ATP synthase membrane subunit c locus 1 [ Mus musculus (house mouse) ]

    Gene ID: 11951, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Atp5mc1provided by MGI
    Official Full Name
    ATP synthase membrane subunit c locus 1provided by MGI
    Primary source
    MGI:MGI:107653
    See related
    Ensembl:ENSMUSG00000006057 AllianceGenome:MGI:107653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atp5g1
    Summary
    Predicted to enable ligand-gated channel activity. Predicted to be involved in several processes, including ATP synthesis coupled proton transport; cellular response to L-glutamate; and negative regulation of mitochondrial membrane potential. Predicted to act upstream of or within ion transport. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; liver; and nervous system. Orthologous to human ATP5MC1 (ATP synthase membrane subunit c locus 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 958.8), duodenum adult (RPKM 383.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 59.33 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95963619..95966520, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96072793..96075694, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) Neighboring gene ubiquitin-conjugating enzyme E2Z Neighboring gene STARR-seq mESC enhancer starr_30532 Neighboring gene predicted gene, 22423 Neighboring gene calcium binding and coiled-coil domain 2 Neighboring gene STARR-seq mESC enhancer starr_30533 Neighboring gene tubulin tyrosine ligase-like family, member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial ATP synthase levels in brown adipose tissue are governed by the c-Fo subunit P1 isoform. Kramarova TV, et al. FASEB J, 2008 Jan. PMID 17666453
    2. Sequence of a mouse embryo cDNA clone encoding proteolipid subunit 9 (P1) of the mitochondrial H(+)-ATP synthase. Pikó L, et al. Biochim Biophys Acta, 1994 Feb 8. PMID 8305451
    3. Patterns of mRNA prevalence and expression of B1 and B2 transcripts in early mouse embryos. Taylor KD, et al. Development, 1987 Dec. PMID 3503701
    4. Mitochondrial biogenesis in early mouse embryos: expression of the mRNAs for subunits IV, Vb, and VIIc of cytochrome c oxidase and subunit 9 (P1) of H(+)-ATP synthase. Taylor KD, et al. Mol Reprod Dev, 1995 Jan. PMID 7535541
    5. Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics. Ponce JM, et al. J Am Heart Assoc, 2020 Apr 7. PMID 32248761, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ligand-gated channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cation channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in distal axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    part_of mitochondrial proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting two-sector ATPase complex, proton-transporting domain IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase F(0) complex subunit C1, mitochondrial
    Names
    ATP synthase lipid-binding protein, mitochondrial
    ATP synthase proteolipid P1
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)
    ATPase protein 9
    ATPase subunit c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161419.1 → NP_001154891.1  ATP synthase F(0) complex subunit C1, mitochondrial

      See identical proteins and their annotated locations for NP_001154891.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1.
      Source sequence(s)
      AK009883, BY276643, CF749235
      Consensus CDS
      CCDS25289.1
      UniProtKB/Swiss-Prot
      Q3TIE9, Q9CR84
      Related
      ENSMUSP00000103312.2, ENSMUST00000107684.2
      Conserved Domains (1) summary
      MTH00222
      Location:62 → 136
      ATP9; ATP synthase F0 subunit 9; Provisional

    2. NM_001417327.1 → NP_001404256.1  ATP synthase F(0) complex subunit C1, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AL603682
      UniProtKB/Swiss-Prot
      Q3TIE9, Q9CR84
      Related
      ENSMUSP00000103314.2, ENSMUST00000107686.8

    3. NM_007506.6 → NP_031532.2  ATP synthase F(0) complex subunit C1, mitochondrial

      See identical proteins and their annotated locations for NP_031532.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AK010868, BY297329, CF749235
      Consensus CDS
      CCDS25289.1
      UniProtKB/Swiss-Prot
      Q3TIE9, Q9CR84
      Related
      ENSMUSP00000088029.6, ENSMUST00000090541.12
      Conserved Domains (1) summary
      MTH00222
      Location:62 → 136
      ATP9; ATP synthase F0 subunit 9; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      95963619..95966520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR84.1 GenPept UniProtKB/Swiss-Prot:Q9CR84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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