Atox1 antioxidant 1 copper chaperone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atox1provided by MGI
Official Full Name: antioxidant 1 copper chaperoneprovided by MGI
Primary source: MGI:MGI:1333855
See related: Ensembl:ENSMUSG00000018585 AllianceGenome:MGI:1333855
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Atx1
Summary: Predicted to enable several functions, including ATPase binding activity; copper-dependent protein binding activity; and cuprous ion binding activity. Acts upstream of or within cellular copper ion homeostasis and copper ion transport. Predicted to be active in cytosol. Orthologous to human ATOX1 (antioxidant 1 copper chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 244.6), kidney adult (RPKM 226.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 33.07 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (55337463..55352034, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (55446637..55461208, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Whole-Transcriptome Sequencing Analyses of Nuclear Antixoxidant-1 in Endothelial Cells: Role in Inflammation and Atherosclerosis.
Title: Whole-Transcriptome Sequencing Analyses of Nuclear Antixoxidant-1 in Endothelial Cells: Role in Inflammation and Atherosclerosis.
Copper enhances genotoxic drug resistance via ATOX1 activated DNA damage repair.
Title: Copper enhances genotoxic drug resistance via ATOX1 activated DNA damage repair.
Cu-dependent Atox1 binding to TRAF4 plays an important role in Atox1 nuclear translocation and ROS-dependent inflammatory responses in TNF-alpha-stimulated vascular endothelial cells.
Title: Novel interaction of antioxidant-1 with TRAF4: role in inflammatory responses in endothelial cells.
Transduced Tat-ATOX1 markedly suppressed inflammatory responses in LPS-exposed Raw 264.7 cells and in a TPA-induced animal model by inhibition of pro-inflammatory mediator proteins, as well as activated NF-B and MAPK, suggesting that Tat-ATOX1 may contribute to the development of therapeutic proteins for the treatment of skin inflammation.
Title: Tat-ATOX1 inhibits inflammatory responses via regulation of MAPK and NF-κB pathways.
ATOX1 appeared ubiquitously expressed throughout the cells until compaction; in subsequent embryo stages, ATOX1 relocalized to cytoplasmic perinuclear domains in the inner cell mass. Silencing of Oct4 did not affect Atox1 expression, but silencing of Atox1 at the 2-cell stage strongly diminished Oct4 expression in 16-cell embryos.
Title: Copper chaperone ATOX1 regulates pluripotency factor OCT4 in preimplantation mouse embryos.
Cu chaperone function of Atox1 mediated through Cu transporter ATP7A is required for VEGF-induced angiogenesis via activation of Cu enzyme lysyl oxidase.
Title: Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function.
Atox1 is involved in neointimal formation after vascular injury through promoting vascular smooth muscle cell migration and inflammatory cell recruitment in injured vessels
Title: Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury.
Atox1 functions to prevent Ang II-induced endothelial dysfunction and hypercontraction in resistant vessels, as well as hypertension.
Title: Role of copper transport protein antioxidant 1 in angiotensin II-induced hypertension: a key regulator of extracellular superoxide dismutase.
the importance of Atox1, not only as a metallochaperone for delivering Cu to cuproenzymes, but also as a key player in maintaining the proper distribution and organization of Cu at the cellular level
Title: Copper redistribution in Atox1-deficient mouse fibroblast cells.
Atox1 upregulates prion protein expression.
Title: Activation and repression of prion protein expression by key regions of intron 1.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236579

RH136058 (e-PCR)
- UniSTS:210053

RH129645 (e-PCR)
- UniSTS:212942

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables copper chaperone activity	IBA Inferred from Biological aspect of Ancestor more info
enables copper chaperone activity	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables cuprous ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in copper ion export	ISO Inferred from Sequence Orthology more info
involved_in copper ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within copper ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: copper transport protein ATOX1

Names: ATX1 (antioxidant protein 1) homolog 1; metal transport protein ATX1

NP_033850.1

EC 6.2.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009720.3 → NP_033850.1 copper transport protein ATOX1

See identical proteins and their annotated locations for NP_033850.1

Status: VALIDATED

Source sequence(s)

BP773958, BQ747750

Consensus CDS

CCDS36158.1

UniProtKB/Swiss-Prot

O08997, Q5NCU2

Related

ENSMUSP00000104485.2, ENSMUST00000108857.2

Conserved Domains (1) summary

cd00371
Location:5 → 63

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...