Neurod6 neurogenic differentiation 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Neurod6provided by MGI
Official Full Name: neurogenic differentiation 6provided by MGI
Primary source: MGI:MGI:106593
See related: Ensembl:ENSMUSG00000037984 AllianceGenome:MGI:106593
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nex; Atoh2; Math2; Nex1m; Math-2; bHLHa2
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within dentate gyrus development. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; integumental system; limb; nervous system; and sensory organ. Orthologous to human NEUROD6 (neuronal differentiation 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 67.3), CNS E14 (RPKM 57.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.53 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (55654803..55658248, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (55677818..55681263, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of perinatally born glutamatergic neurons of the mouse olfactory bulb based on NeuroD6 expression reveals their resistance to sensory deprivation.
Title: Characterization of perinatally born glutamatergic neurons of the mouse olfactory bulb based on NeuroD6 expression reveals their resistance to sensory deprivation.
The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement. Results show that NeuroD6 VTA neurons exert distinct regulation over specific aspects of reward-related behavior, findings that contribute to the current understanding of VTA neurocircuitry.
Title: The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement.
Study finds that the combinatorial expression of gastrin releasing peptide and Neurod6 defines midbrain dopaminergic subpopulations with unique features.
Title: Combinatorial Expression of Grp and Neurod6 Defines Dopamine Neuron Populations with Distinct Projection Patterns and Disease Vulnerability.
This study identify the transcription factor NEUROD6 as a specific marker for a novel subset of midbrain dopaminergic neurons in the ventral midbrain that project to the lateral septum.
Title: Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins.
we have identified basic helix-loop-helix (bHLH) transcription factors Neurod2 and Neurod6 as key regulators of fasciculation and targeted axogenesis in the mouse neocortex
Title: Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions.
When injected with tamoxifen, adult NEX-CreERT2 mice induced reporter gene expression exclusively in projection neurons of the neocortex and hippocampus.
Title: In vivo imaging and noninvasive ablation of pyramidal neurons in adult NEX-CreERT2 mice.
This ssudy demonistrated that Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.
Title: Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.
In the mature retina, NeuroD6 fate-mapped cells include cells in the upper part of the inner nuclear layer (INL), just below the outer plexiform layer, cells in the inner portion of the INL, and cells in the germ-cell layer.
Title: NeuroD factors regulate cell fate and neurite stratification in the developing retina.
Math2,regulates YB-1 transcription in the postnatal brain through an E-box sequence in the 5'-UTR of the gene.
Title: YB-1 transcription in the postnatal brain is regulated by a bHLH transcription factor Math2 through an E-box sequence in the 5'-UTR of the gene.
cloning and some features of a novel human gene, MATH2, which encodes a protein of 337 amino acid residues with a basic helix loop helix domain and exhibits 98% similarity to mouse Math2
Title: Cloning, chromosome localization and features of a novel human gene, MATH2.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

U29086 (e-PCR)
- UniSTS:125713

NEUROD6 (e-PCR)
- UniSTS:503634

Neurod6 (e-PCR), detects polymorphism
- UniSTS:528215

Neurod6 (e-PCR), detects polymorphism
- UniSTS:531344

D44480 (e-PCR)
- UniSTS:179377

BF386980 (e-PCR)
- UniSTS:243902

Neurod6 (e-PCR), detects polymorphism
- UniSTS:507084

PMC57740P1 (e-PCR)
- UniSTS:273364

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dentate gyrus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neurogenic differentiation factor 6

Names: atonal homolog 2; helix-loop-helix protein mATH-2; protein NEX-1; protein atonal homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009717.2 → NP_033847.1 neurogenic differentiation factor 6

See identical proteins and their annotated locations for NP_033847.1

Status: VALIDATED

Source sequence(s)

AK144360, AK144377, CJ237964

Consensus CDS

CCDS20168.1

UniProtKB/Swiss-Prot

P48986

UniProtKB/TrEMBL

Q3UN97, Q5M8T7

Related

ENSMUSP00000047016.9, ENSMUST00000044767.10

Conserved Domains (2) summary

pfam12533
Location:153 → 272

Neuro_bHLH; Neuronal helix-loop-helix transcription factor

cd19722
Location:82 → 151

bHLH_TS_NeuroD6_ATOH2; basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) and similar proteins