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    Arhgap5 Rho GTPase activating protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 11855, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Arhgap5provided by MGI
    Official Full Name
    Rho GTPase activating protein 5provided by MGI
    Primary source
    MGI:MGI:1332637
    See related
    Ensembl:ENSMUSG00000035133 AllianceGenome:MGI:1332637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p190B; p190-B
    Summary
    Predicted to enable SH2 domain binding activity. Acts upstream of or within several processes, including positive regulation of cell migration; positive regulation of mesenchymal cell proliferation; and regulation of cell size. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ARHGAP5 (Rho GTPase activating protein 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 9.8), frontal lobe adult (RPKM 6.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 C1; 12 22.16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (52550555..52618761)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (52503763..52571978)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35071 Neighboring gene predicted gene, 35135 Neighboring gene RIKEN cDNA 1700031P21 gene Neighboring gene STARR-seq mESC enhancer starr_32132 Neighboring gene STARR-positive B cell enhancer ABC_E4025 Neighboring gene predicted gene, 35239 Neighboring gene predicted gene, 24859

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Hinge A, et al. Nat Commun, 2017 Feb 8. PMID 28176763, Free PMC Article
    2. p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment. Raman R, et al. Leukemia, 2013 Nov. PMID 23563238, Free PMC Article
    3. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Xu H, et al. Blood, 2009 Oct 22. PMID 19713466, Free PMC Article
    4. Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Sordella R, et al. Cell, 2003 Apr 18. PMID 12705864
    5. p190-B RhoGAP regulates mammary ductal morphogenesis. Chakravarty G, et al. Mol Endocrinol, 2003 Jun. PMID 12637587

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study suggests a link between p190-B-RhoGAP and non-canonical TGF-beta signaling in hematopoietic stem and progenitor cell differentiation.
      Title: p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.
    2. Loss of p190-B expression is associated with defective hematopoiesis.
      Title: p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment.
    3. Rac1 activity and oxidative stress are elevated in tumors expressing exogenous p190B suggesting that p190B may promote tumorigenesis through a Rac1/ROS dependent mechanism.
      Title: P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis.
    4. p190B haploinsufficiency in the epithelium inhibits MMTV-Neu tumor initiation. p190B deficiency in the vasculature is responsible, in part, for the inhibition of MMTV-Neu tumor progression.
      Title: Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.
    5. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
      Title: Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
    6. IGF signaling through p190-B and IRS proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal interactions necessary to sustain mammary bud morphogenesis
      Title: Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development.
    7. Mice lacking the Rho-inhibitory protein, p190-B RhoGAP, are 30% reduced in size and exhibit developmental defects strikingly similar to those seen in mice lacking the CREB transcription factor.
      Title: Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development.
    8. Results suggest that p190-B regulates ductal morphogenesis, at least in part, by modulating the IGF signaling axis
      Title: p190-B RhoGAP regulates mammary ductal morphogenesis.
    9. precise control of p190-B Rho GTPase-activating protein activity is critical for normal branching morphogenesis during mammary gland development
      Title: P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 5
    Names
    rho-type GTPase-activating protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408721.1 → NP_001395650.1  rho GTPase-activating protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819
      UniProtKB/Swiss-Prot
      E9PYT0, E9Q0L8, P97393
      Related
      ENSMUSP00000106353.2, ENSMUST00000110725.2

    2. NM_001408722.1 → NP_001395651.1  rho GTPase-activating protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819
      UniProtKB/Swiss-Prot
      E9PYT0, E9Q0L8, P97393
      Related
      ENSMUSP00000151809.2, ENSMUST00000219443.2

    3. NM_001408723.1 → NP_001395652.1  rho GTPase-activating protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819

    4. NM_001408724.1 → NP_001395653.1  rho GTPase-activating protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819

    5. NM_009706.3 → NP_033836.2  rho GTPase-activating protein 5 isoform 1

      See identical proteins and their annotated locations for NP_033836.2

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819
      Consensus CDS
      CCDS36443.1
      UniProtKB/Swiss-Prot
      E9PYT0, E9Q0L8, P97393
      Conserved Domains (4) summary
      smart00441
      Location:428 → 481
      FF; Contains two conserved F residues
      cd04373
      Location:1261 → 1445
      RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
      pfam16512
      Location:260 → 338
      RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
      cl38936
      Location:31 → 246
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. NR_176796.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819

    2. NR_176797.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC114002, AC155819

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      52550555..52618761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97393.3 GenPept UniProtKB/Swiss-Prot:P97393

    Gene LinkOut

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