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    Aqr aquarius [ Mus musculus (house mouse) ]

    Gene ID: 11834, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Aqrprovided by MGI
    Official Full Name
    aquariusprovided by MGI
    Primary source
    MGI:MGI:1276102
    See related
    Ensembl:ENSMUSG00000040383 AllianceGenome:MGI:1276102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0560
    Summary
    Predicted to enable 3'-5' RNA helicase activity; mRNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of U2-type catalytic step 2 spliceosome. Orthologous to human AQR (aquarius intron-binding spliceosomal factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.8), limb E14.5 (RPKM 15.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aqr in Genome Data Viewer
    Location:
    2 E4; 2 57.57 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (113931642..114005788, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (114101161..114175339, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene actin, alpha, cardiac muscle 1 divergent transcript Neighboring gene predicted gene, 46757 Neighboring gene predicted gene, 54143 Neighboring gene VISTA enhancer mm182 Neighboring gene STARR-positive B cell enhancer mm9_chr2:113971248-113971549 Neighboring gene STARR-positive B cell enhancer ABC_E1593 Neighboring gene STARR-seq mESC enhancer starr_05403 Neighboring gene microRNA 7002 Neighboring gene zinc finger protein 770 Neighboring gene STARR-seq mESC enhancer starr_05404 Neighboring gene STARR-seq mESC enhancer starr_05405 Neighboring gene STARR-seq mESC enhancer starr_05406 Neighboring gene STARR-seq mESC enhancer starr_05407 Neighboring gene STARR-seq mESC enhancer starr_05408 Neighboring gene STARR-seq mESC enhancer starr_05409 Neighboring gene predicted gene, 31146

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Aquarius, a novel gene isolated by gene trapping with an RNA-dependent RNA polymerase motif. Sam M, et al. Dev Dyn, 1998 Jun. PMID 9626505
    2. An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro. Forrester LM, et al. Proc Natl Acad Sci U S A, 1996 Feb 20. PMID 8643689, Free PMC Article
    3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA helicase aquarius
    Names
    intron-binding protein aquarius
    intron-binding protein of 160 kDa
    NP_001277717.1
    NP_001403810.1
    NP_001403811.1
    NP_001403813.1
    NP_001403814.1
    NP_001403815.1
    NP_001403816.1
    NP_001403818.1
    NP_001403819.1
    NP_033832.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290788.2 → NP_001277717.1  RNA helicase aquarius isoform b

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569
      Consensus CDS
      CCDS71114.1
      UniProtKB/TrEMBL
      A2AQA7
      Related
      ENSMUSP00000099602.5, ENSMUST00000102543.5
      Conserved Domains (4) summary
      pfam13086
      Location:805 → 1111
      AAA_11; AAA domain
      pfam13245
      Location:808 → 880
      AAA_19; Part of AAA domain
      pfam16399
      Location:18 → 802
      Aquarius_N; Intron-binding protein aquarius N-terminus
      cl22977
      Location:1119 → 1308
      UvrD_C_2; UvrD-like helicase C-terminal domain

    2. NM_001416881.1 → NP_001403810.1  RNA helicase aquarius isoform c

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569

    3. NM_001416882.1 → NP_001403811.1  RNA helicase aquarius isoform d

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569

    4. NM_001416884.1 → NP_001403813.1  RNA helicase aquarius isoform g

      Status: VALIDATED

      Source sequence(s)
      AL844569

    5. NM_001416885.1 → NP_001403814.1  RNA helicase aquarius isoform h

      Status: VALIDATED

      Source sequence(s)
      AL844569

    6. NM_001416886.1 → NP_001403815.1  RNA helicase aquarius isoform i

      Status: VALIDATED

      Source sequence(s)
      AL844569
      Related
      ENSMUST00000129504.8

    7. NM_001416887.1 → NP_001403816.1  RNA helicase aquarius isoform j

      Status: VALIDATED

      Source sequence(s)
      AL844569

    8. NM_001416889.1 → NP_001403818.1  RNA helicase aquarius isoform e

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569

    9. NM_001416890.1 → NP_001403819.1  RNA helicase aquarius isoform f

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569

    10. NM_009702.4 → NP_033832.2  RNA helicase aquarius isoform a

      See identical proteins and their annotated locations for NP_033832.2

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569
      Consensus CDS
      CCDS16565.1
      UniProtKB/Swiss-Prot
      P97871, Q3U9N1, Q3ULE8, Q80TX8, Q8CFQ3
      Related
      ENSMUSP00000047157.7, ENSMUST00000043160.13
      Conserved Domains (4) summary
      pfam13086
      Location:805 → 1111
      AAA_11; AAA domain
      pfam13245
      Location:808 → 880
      AAA_19; Part of AAA domain
      pfam16399
      Location:18 → 802
      Aquarius_N; Intron-binding protein aquarius N-terminus
      cl22977
      Location:1119 → 1308
      UvrD_C_2; UvrD-like helicase C-terminal domain

    RNA

    1. NR_184400.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC133157, AL844569

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      113931642..114005788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFQ3.2 GenPept UniProtKB/Swiss-Prot:Q8CFQ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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