Aplp1 amyloid beta precursor like protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aplp1provided by MGI
Official Full Name: amyloid beta precursor like protein 1provided by MGI
Primary source: MGI:MGI:88046
See related: Ensembl:ENSMUSG00000006651 AllianceGenome:MGI:88046
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable adrenergic receptor binding activity and identical protein binding activity. Acts upstream of or within several processes, including extracellular matrix organization; mRNA polyadenylation; and regulation of translation. Located in Golgi apparatus and membrane. Is expressed in several structures, including genitourinary system; nervous system; pancreas trunk epithelium; sensory organ; and tooth. Orthologous to human APLP1 (amyloid beta precursor like protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 245.4), frontal lobe adult (RPKM 216.0) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 18.32 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30134405..30144960, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30434980..30445582, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanistic basis for receptor-mediated pathological alpha-synuclein fibril cell-to-cell transmission in Parkinson's disease.
Title: Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
Title: Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
Mutation in Sodium-Glucose Cotransporter 2 Results in Down-Regulation of Amyloid Beta (A4) Precursor-Like Protein 1 in Young Age, Which May Lead to Poor Memory Retention in Old Age.
Title: Mutation in Sodium-Glucose Cotransporter 2 Results in Down-Regulation of Amyloid Beta (A4) Precursor-Like Protein 1 in Young Age, Which May Lead to Poor Memory Retention in Old Age.
APLP1 exhibits synaptogenic activity, involving trans-synaptic dimerization. APLP1 knock-out mice show impaired basal transmission and a reduced mEPSC frequency.
Title: APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.
Results suggest that APLP1 deficiency on its own does not lead to defects in synaptic plasticity, but affects synaptic transmission and network inhibition in the dentate gyrus
Title: Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.
[review] A role of APP and its two closely related homologues APLP1 and APLP2 has been determined in various aspects of nervous system development and function, in particular, for synapse formation and function.
Title: Functions of the APP gene family in the nervous system: insights from mouse models.
findings demonstrated that NB-2 interacts with APLP and that both NB-2 and APLP1 are localized at presynaptic sites, suggesting that NB-2 associates with APLP1 in a cis manner on the presynaptic membrane
Title: A cis-complex of NB-2/contactin-5 with amyloid precursor-like protein 1 is localized on the presynaptic membrane.
Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate.
Title: Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate.
The results demonstrated that cell viability and neurite outgrowth of N2a cells undergoing knockdown of Aplp1 were significantly reduced, compared with N2a cells undergoing knockdown of either App or Aplp2.
Title: Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference.
Cytoplasmic polyadenylation element (CPE) binding factor binds the small intracellular domain (ICD) of APLP1.
Title: Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Aplp1 (e-PCR), detects polymorphism
- UniSTS:259195

D1Bda13 (e-PCR)
- UniSTS:239760

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-2A adrenergic receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-2A adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables alpha-2B adrenergic receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-2B adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables alpha-2C adrenergic receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-2C adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to norepinephrine stimulus	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytosolic mRNA polyadenylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: amyloid beta precursor like protein 1

Names: APLP; APLP-1; amyloid beta (A4) precursor-like protein 1; amyloid-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007467.4 → NP_031493.2 amyloid beta precursor like protein 1 precursor

See identical proteins and their annotated locations for NP_031493.2

Status: VALIDATED

Source sequence(s)

AC149067

Consensus CDS

CCDS21092.1

UniProtKB/Swiss-Prot

A0A0R4IZZ1, Q03157, Q3U311, Q8VC38

UniProtKB/TrEMBL

Q3TUB1

Related

ENSMUSP00000006828.8, ENSMUST00000006828.9

Conserved Domains (3) summary

smart00006
Location:46 → 211

A4_EXTRA; amyloid A4

pfam12925
Location:289 → 471

APP_E2; E2 domain of amyloid precursor protein

cl41775
Location:568 → 652

JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins