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    Prelp proline arginine-rich end leucine-rich repeat [ Mus musculus (house mouse) ]

    Gene ID: 116847, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Prelpprovided by MGI
    Official Full Name
    proline arginine-rich end leucine-rich repeatprovided by MGI
    Primary source
    MGI:MGI:2151110
    See related
    Ensembl:ENSMUSG00000041577 AllianceGenome:MGI:2151110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SLRR2A; 7330409J17Rik
    Summary
    Predicted to enable heparin binding activity. Acts upstream of or within cell aging. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; connective tissue; eye; nervous system; and reproductive system. Orthologous to human PRELP (proline and arginine rich end leucine rich repeat protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 99.9), lung adult (RPKM 77.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prelp in Genome Data Viewer
    Location:
    1 E4; 1 58.02 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133838042..133857820, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133910304..133930102, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31515 Neighboring gene opticin Neighboring gene predicted gene 1627 Neighboring gene bone marrow associated noncoding RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PRELP promotes myocardial fibrosis and ventricular remodelling after acute myocardial infarction by the wnt/β-catenin signalling pathway. Zhang Y, et al. Cardiovasc J Afr, 2022 Sep-Oct 23. PMID 35788244, Free PMC Article
    2. AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice. Birke MT, et al. Gene Ther, 2014 May. PMID 24670995, Free PMC Article
    3. The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-kappaB inhibitor that impairs osteoclastogenesis. Rucci N, et al. J Cell Biol, 2009 Nov 30. PMID 19951916, Free PMC Article
    4. Characterization and expression of murine PRELP. Grover J, et al. Matrix Biol, 2001 Dec. PMID 11731272
    5. PRELP (proline/arginine-rich end leucine-rich repeat protein) promotes osteoblastic differentiation of preosteoblastic MC3T3-E1 cells by regulating the β-catenin pathway. Li H, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26809092

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRELP promotes myocardial fibrosis and ventricular remodelling after acute myocardial infarction by the wnt/beta-catenin signalling pathway.
      Title: PRELP promotes myocardial fibrosis and ventricular remodelling after acute myocardial infarction by the wnt/β-catenin signalling pathway.
    2. Therefore, this study established a new role of PRELP in modulating beta-catenin/connexin43 pathway and osteoblast differentiation.
      Title: PRELP (proline/arginine-rich end leucine-rich repeat protein) promotes osteoblastic differentiation of preosteoblastic MC3T3-E1 cells by regulating the β-catenin pathway.
    3. when delivered via an AAV vector to the retina of mice, PRELP inhibited laser-induced choroidal neovascularization by 60%. PRELP reduced deposition of membrane attack complex in vivo by 25.5%.
      Title: AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice.
    4. PRELP has a role in skeletal remodeling.
      Title: The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-kappaB inhibitor that impairs osteoclastogenesis.
    5. expressed in cartilage throughout both fetal development and post-natal life
      Title: Characterization and expression of murine PRELP.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent conferring compression resistance RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular senescence IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolargin
    Names
    proline-arginine-rich end leucine-rich repeat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054077.4 → NP_473418.3  prolargin precursor

      See identical proteins and their annotated locations for NP_473418.3

      Status: VALIDATED

      Source sequence(s)
      AK037150, AK047480
      Consensus CDS
      CCDS15300.1
      UniProtKB/Swiss-Prot
      Q9JK53
      UniProtKB/TrEMBL
      Q543S0, Q8CAZ9
      Related
      ENSMUSP00000048803.6, ENSMUST00000048432.6
      Conserved Domains (3) summary
      PRK15370
      Location:129 → 349
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      smart00013
      Location:68 → 103
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:100 → 123
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      133838042..133857820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529084.5 → XP_006529147.1  prolargin isoform X1

      See identical proteins and their annotated locations for XP_006529147.1

      UniProtKB/Swiss-Prot
      Q9JK53
      UniProtKB/TrEMBL
      Q543S0, Q8CAZ9
      Conserved Domains (3) summary
      PRK15370
      Location:129 → 349
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      smart00013
      Location:68 → 103
      LRRNT; Leucine rich repeat N-terminal domain
      sd00033
      Location:100 → 123
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JK53.2 GenPept UniProtKB/Swiss-Prot:Q9JK53

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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