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    Alk anaplastic lymphoma kinase [ Mus musculus (house mouse) ]

    Gene ID: 11682, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Alkprovided by MGI
    Official Full Name
    anaplastic lymphoma kinaseprovided by MGI
    Primary source
    MGI:MGI:103305
    See related
    Ensembl:ENSMUSG00000055471 AllianceGenome:MGI:103305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcrz; CD246
    Summary
    Predicted to enable identical protein binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in energy homeostasis; negative regulation of lipid catabolic process; and positive regulation of dendrite development. Acts upstream of or within several processes, including hippocampus development; response to environmental enrichment; and swimming behavior. Predicted to be located in axon; cell body; and plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ALK (ALK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E1.3; 17 43.77 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (72174206..72911719, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71868988..72604702, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43179 Neighboring gene STARR-seq mESC enhancer starr_43180 Neighboring gene photoreceptor cilium actin regulator Neighboring gene predicted gene, 30140 Neighboring gene CAP-GLY domain containing linker protein family, member 4 Neighboring gene STARR-seq mESC enhancer starr_43182 Neighboring gene predicted gene, 41613 Neighboring gene budding uninhibited by benzimidazoles 3 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_43183 Neighboring gene STARR-seq mESC enhancer starr_43185 Neighboring gene predicted gene, 53975 Neighboring gene STARR-seq mESC enhancer starr_43186 Neighboring gene predicted gene, 53976 Neighboring gene STARR-positive B cell enhancer ABC_E5626 Neighboring gene STARR-seq mESC enhancer starr_43189 Neighboring gene STARR-positive B cell enhancer ABC_E171 Neighboring gene yippee like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ALK-transformed mature T lymphocytes restore early thymus progenitor features. Congras A, et al. J Clin Invest, 2020 Dec 1. PMID 33141118, Free PMC Article
    2. Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice. Kohler H, et al. Thyroid, 2019 Oct. PMID 31526103, Free PMC Article
    3. Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice. Schweitzer P, et al. Neuropharmacology, 2016 Aug. PMID 26946429, Free PMC Article
    4. Anaplastic lymphoma kinase regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area. Dutton JW 3rd, et al. Addict Biol, 2017 May. PMID 26752591, Free PMC Article
    5. Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism. Witek B, et al. PLoS One, 2015. PMID 25955180, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis.
      Title: The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis.
    2. LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.
      Title: LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.
    3. Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation.
      Title: Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation.
    4. Mst1/2-ALK promotes NLRP3 inflammasome activation and cell apoptosis during Listeria monocytogenes infection.
      Title: Mst1/2-ALK promotes NLRP3 inflammasome activation and cell apoptosis during Listeria monocytogenes infection.
    5. Oncogenic ALK (F1174L) drives tumorigenesis in cutaneous squamous cell carcinoma.
      Title: Oncogenic ALK (F1174L) drives tumorigenesis in cutaneous squamous cell carcinoma.
    6. A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.
      Title: A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.
    7. ALK-transformed mature T lymphocytes restore early thymus progenitor features.
      Title: ALK-transformed mature T lymphocytes restore early thymus progenitor features.
    8. Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice.
      Title: Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice.
    9. Anaplastic lymphoma kinase (ALK) is a novel regulator of NLRP3 inflammasome activation in macrophages. Mechanically, ALK-mediated NF-kappaB activation was required for the priming step of NLRP3 upregulation, whereas ALK-mediated lipid peroxidation contributed to the sensing step of NLRP3-NEK7 complex formation.
      Title: ALK is required for NLRP3 inflammasome activation in macrophages.
    10. NLRR1 appears to be an extracellular negative regulator of ALK signalling in neuroblastoma and neuronal development.
      Title: Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor signaling protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to environmental enrichment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within swimming behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ALK tyrosine kinase receptor
    NP_031465.2
    XP_036016161.1
    XP_036016162.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007439.2 → NP_031465.2  ALK tyrosine kinase receptor precursor

      See identical proteins and their annotated locations for NP_031465.2

      Status: VALIDATED

      Source sequence(s)
      AC154458, AK051358, BE652096, D83002
      Consensus CDS
      CCDS37688.1
      UniProtKB/Swiss-Prot
      E9QKV3, P97793
      Related
      ENSMUSP00000083840.5, ENSMUST00000086639.6
      Conserved Domains (6) summary
      cd06263
      Location:484 → 635
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00192
      Location:445 → 471
      LDLa; Low-density lipoprotein receptor domain class A
      cd05036
      Location:1113 → 1389
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
      pfam00629
      Location:484 → 640
      MAM; MAM domain, meprin/A5/mu
      pfam07714
      Location:1120 → 1387
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14670
      Location:991 → 1025
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      72174206..72911719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160268.1 → XP_036016161.1  ALK tyrosine kinase receptor isoform X1

      Conserved Domains (2) summary
      PRK12323
      Location:454 → 627
      PRK12323; DNA polymerase III subunit gamma/tau
      cd05036
      Location:160 → 436
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

    2. XM_036160269.1 → XP_036016162.1  ALK tyrosine kinase receptor isoform X2

      Conserved Domains (2) summary
      PRK12323
      Location:431 → 604
      PRK12323; DNA polymerase III subunit gamma/tau
      cd05036
      Location:137 → 413
      PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

    RNA

    1. XR_001782029.3 RNA Sequence

    2. XR_385265.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97793.2 GenPept UniProtKB/Swiss-Prot:P97793

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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