Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aldh3a1provided by MGI
Official Full Name: aldehyde dehydrogenase family 3, subfamily A1provided by MGI
Primary source: MGI:MGI:1353451
See related: Ensembl:ENSMUSG00000019102 AllianceGenome:MGI:1353451
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ahd4; Aldh; Ahd-4; Aldh3
Summary: Enables 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytoplasm. Is integral component of membrane. Is expressed in several structures, including alimentary system; decidua; early conceptus; gonad; and liver. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 55.3), stomach adult (RPKM 53.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61099336..61109244)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61208510..61218418)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Generation and characterization of Aldh3-Cre transgenic mice as a tool for conditional gene deletion in postnatal cornea.
Title: Generation and characterization of Aldh3-Cre transgenic mice as a tool for conditional gene deletion in postnatal cornea.
This study found that oncogene-transformed embryonic fibroblasts prepared from Per2-mutant (Per2(m/m) ) mice, which are susceptible to both spontaneous and radiation-induced tumorigenesis, were resistant against common chemotherapeutic drugs and that this resistance is associated with up-regulation of the aldehyde dehydrogenase 3a1 (Aldh3a1) gene.
Title: Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene.
The alcohol dehydrogenase 3 (ADH3-/-) control mice exhibited increased activities of both osteoblasts and osteoclasts and lower bone masses than the WT control mice.
Title: The Contribution of Alcohol Dehydrogenase 3 to the Development of Alcoholic Osteoporosis in Mice.
It is responsible for systemic alcohol metabolism.
Title: Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in mice.
ALDH3A1 activation by d-limonene significantly reduced aldehyde accumulation in SSPCs.
Title: Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.
The corneal phenotype of Aldh3a1 showed no differences were observed in lipid profiles from knockout relative to wild type mice; however, changes in protein profiles of acyl-CoA binding protein (m/z 9966) and histone H4.4 (m/z 11308) were found to be increased in the corneal epithelial layer of knockout mice.
Title: Corneal haze phenotype in Aldh3a1-null mice: In vivo confocal microscopy and tissue imaging mass spectrometry.
ALDH3A1 has a role in the maintenance of corneal epithelial homeostasis by simultaneously modulating proliferation and differentiation through both enzymatic and non-enzymatic mechanisms
Title: ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis.
ADH3 protects liver from steatosis by supporting normal lipid metabolism and prevents progression of steatosis into steatohepatitis by maintaining the cellular glutathione level.
Title: Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.
focused on ALDH3A1, which is enriched in the upper aerodigestive track, and identified Alda-89 as a small molecule that enables ALDH3A1 to metabolize acetaldehyde
Title: Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.
Varying levels of aldehyde dehydrogenase activity in adult murine marrow hematopoietic stem cells are associated with engraftment and cell cycle status.
Title: Varying levels of aldehyde dehydrogenase activity in adult murine marrow hematopoietic stem cells are associated with engraftment and cell cycle status.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Aldh3a1 (e-PCR), detects polymorphism
- UniSTS:461950

NoName (e-PCR)
- UniSTS:491207

U12785 (e-PCR)
- UniSTS:125672

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-chloroallyl aldehyde dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-chloroallyl aldehyde dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 3-chloroallyl aldehyde dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables aldehyde dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables benzaldehyde dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular aldehyde metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular aldehyde metabolic process	IC Inferred by Curator more info	PubMed
involved_in cellular aldehyde metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldehyde dehydrogenase, dimeric NADP-preferring

Names: alcohol dehydrogenase family 3, subfamily A1; aldehyde dehydrogenase 3, stomach cytosolic (class 3); aldehyde dehydrogenase 4; aldehyde dehydrogenase family 3 member A1; dioxin-inducible aldehyde dehydrogenase 3

NP_001106196.1

EC 1.2.1.5

NP_001318041.1

EC 1.2.1.5

NP_031462.2

EC 1.2.1.5

XP_006532086.1

EC 1.2.1.5

XP_006532087.1

EC 1.2.1.5

XP_006532089.1

EC 1.2.1.5

XP_006532090.1

EC 1.2.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112725.1 → NP_001106196.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform 1

See identical proteins and their annotated locations for NP_001106196.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 3. The encoded isoform (1) is shorter than isoform 2. Both variants 1 and 2 encode the same isoform (2).

Source sequence(s)

AK144241, EL957097, EL959139, EL959277, EL961165, EL963960

Consensus CDS

CCDS24808.1

UniProtKB/Swiss-Prot

B1ATI7, P47739, Q9R203

UniProtKB/TrEMBL

Q3UNF5

Related

ENSMUSP00000104356.2, ENSMUST00000108716.8

Conserved Domains (1) summary

cd07132
Location:5 → 447

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
NM_001331112.1 → NP_001318041.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (2).

Source sequence(s)

AL646093, CX734286

UniProtKB/TrEMBL

B7ZN13

Conserved Domains (1) summary

cd07132
Location:5 → 447

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
NM_007436.2 → NP_031462.2 aldehyde dehydrogenase, dimeric NADP-preferring isoform 1

See identical proteins and their annotated locations for NP_031462.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region compared to variant 3. The encoded isoform (1) is shorter than isoform 2. Both variants 1 and 2 encode the same isoform (2).

Source sequence(s)

AK144241, AL646093, EL957097, EL959139, EL959277, EL961165, EL963960

Consensus CDS

CCDS24808.1

UniProtKB/Swiss-Prot

B1ATI7, P47739, Q9R203

UniProtKB/TrEMBL

Q3UNF5

Related

ENSMUSP00000019246.4, ENSMUST00000019246.4

Conserved Domains (1) summary

cd07132
Location:5 → 447

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61099336..61109244

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532024.3 → XP_006532087.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform X1

See identical proteins and their annotated locations for XP_006532087.1

UniProtKB/TrEMBL

B7ZN13

Conserved Domains (1) summary

cd07132
Location:5 → 447

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
XM_006532027.4 → XP_006532090.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform X2

See identical proteins and their annotated locations for XP_006532090.1

UniProtKB/Swiss-Prot

B1ATI7, P47739, Q9R203

UniProtKB/TrEMBL

Q3UNF5

Conserved Domains (1) summary

cd07132
Location:5 → 447

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
XM_006532023.1 → XP_006532086.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform X1

See identical proteins and their annotated locations for XP_006532086.1

UniProtKB/TrEMBL

B7ZN13

Conserved Domains (1) summary

cd07132
Location:5 → 447

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
XM_006532026.1 → XP_006532089.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform X2

See identical proteins and their annotated locations for XP_006532089.1

UniProtKB/Swiss-Prot

B1ATI7, P47739, Q9R203

UniProtKB/TrEMBL

Q3UNF5

Conserved Domains (1) summary

cd07132
Location:5 → 447

ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins