Fgfrl1 fibroblast growth factor receptor-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgfrl1provided by MGI
Official Full Name: fibroblast growth factor receptor-like 1provided by MGI
Primary source: MGI:MGI:2150920
See related: Ensembl:ENSMUSG00000008090 AllianceGenome:MGI:2150920
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FGFR5; FGFR5beta; FGFR5gamma
Summary: Enables fibroblast growth factor binding activity and fibroblast growth factor-activated receptor activity. Acts upstream of or within animal organ development; negative regulation of cell population proliferation; and skeletal system development. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; musculoskeletal system; respiratory system; and sensory organ. Used to study Wolf-Hirschhorn syndrome. Orthologous to human FGFRL1 (fibroblast growth factor receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 80.9), genital fat pad adult (RPKM 60.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 53.24 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (108842051..108854816)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (108694229..108706950)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dissecting the Interaction of FGF8 with Receptor FGFRL1.
Title: Dissecting the Interaction of FGF8 with Receptor FGFRL1.
Functional domains of the FgfrL1 receptor.
Title: Functional domains of the FgfrL1 receptor.
FGFR5 as a co-receptor that is up-regulated by inflammation and promotes FGFR1-induced survival.
Title: Fibroblast growth factor receptor 5 (FGFR5) is a co-receptor for FGFR1 that is up-regulated in beta-cells by cytokine-induced inflammation.
FGFR1 and FGFR2 regulate FGFRL1 expression.
Title: Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes.
FGFRL1 contains three extracellular Ig-like domains and a single transmembrane domain. It lacks the intracellular tyrosine kinase domain, but contains a short intracellular tail with a peculiar histidine-rich motif.The reason why this motif was conserved during evolution in most species, but not in mice, is not clear.
Title: Phylogenetic analysis of receptor FgfrL1 shows divergence of the C-terminal end in rodents.
FgfrL1 is specifically required for embryonic development of slow muscle fibers.
Title: The FgfrL1 receptor is required for development of slow muscle fibers.
Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1.
Title: Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1.
FGFRL1 does not function as a decoy receptor in beta-cells, but rather it enhances ERK1/2 signaling through association of SHP-1 with the receptor's intracellular SH2-binding motif.
Title: Fibroblast growth factor receptor like-1 (FGFRL1) interacts with SHP-1 phosphatase at insulin secretory granules and induces beta-cell ERK1/2 protein activation.
The expression profiles of wildtype and Fgfrl1 mutant kidneys, were compared to identify genes that act downstream of Fgfrl1 signaling during the early steps of nephron formation.
Title: Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.
Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm.
Title: Examination of FGFRL1 as a candidate gene for diaphragmatic defects at chromosome 4p16.3 shows that Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L34111 (e-PCR)
- UniSTS:159412

Fgfrl1 (e-PCR), detects polymorphism
- UniSTS:515314

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables fibroblast growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables non-tyrosine kinase fibroblast growth factor receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within diaphragm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISA Inferred from Sequence Alignment more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibroblast growth factor receptor-like 1

Names: FGF receptor-like protein 1; fibroblast growth factor receptor 5

NP_001157731.1

EC 3.2.1.76

NP_001412742.1

EC 3.2.1.76

NP_001412743.1

EC 3.2.1.76

NP_001412744.1

EC 3.2.1.76

NP_473412.1

EC 3.2.1.76

XP_036020635.1

EC 3.2.1.76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164259.2 → NP_001157731.1 fibroblast growth factor receptor-like 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001157731.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AC123743

Consensus CDS

CCDS51592.1

UniProtKB/Swiss-Prot

Q91V87

Related

ENSMUSP00000108179.4, ENSMUST00000112560.8

Conserved Domains (3) summary

cd00096
Location:151 → 154

Ig; Ig strand A [structural motif]

cd05856
Location:52 → 143

IgI_2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains

cl11960
Location:151 → 259

Ig; Immunoglobulin domain
NM_001425813.1 → NP_001412742.1 fibroblast growth factor receptor-like 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC123743
NM_001425814.1 → NP_001412743.1 fibroblast growth factor receptor-like 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC123743

UniProtKB/Swiss-Prot

Q91V87, Q920C2, Q920C3
NM_001425815.1 → NP_001412744.1 fibroblast growth factor receptor-like 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC123743

UniProtKB/Swiss-Prot

Q91V87, Q920C2, Q920C3
NM_054071.3 → NP_473412.1 fibroblast growth factor receptor-like 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_473412.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC123743

Consensus CDS

CCDS19518.1

UniProtKB/Swiss-Prot

Q91V87, Q920C2, Q920C3

Related

ENSMUSP00000013633.9, ENSMUST00000013633.12

Conserved Domains (3) summary

cd05856
Location:153 → 234

Ig2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1)

pfam07679
Location:29 → 112

I-set; Immunoglobulin I-set domain

cl11960
Location:257 → 351

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

108842051..108854816

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164742.1 → XP_036020635.1 fibroblast growth factor receptor-like 1 isoform X2

Conserved Domains (3) summary

cd00096
Location:151 → 154

Ig; Ig strand A [structural motif]

cd05856
Location:52 → 143

IgI_2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains

cl11960
Location:151 → 259

Ig; Immunoglobulin domain