Alcam activated leukocyte cell adhesion molecule [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alcamprovided by MGI
Official Full Name: activated leukocyte cell adhesion moleculeprovided by MGI
Primary source: MGI:MGI:1313266
See related: Ensembl:ENSMUSG00000022636 AllianceGenome:MGI:1313266
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BEN; SC1; MuSC; CD166; DM-GRASP
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within motor neuron axon guidance. Located in axon; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and vibrissa. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 24.3), CNS E11.5 (RPKM 16.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B5; 16 32.88 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (52069359..52273444, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (52248996..52453081, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ALCAM Deficiency Alleviates LPS-Induced Acute Lung Injury by Inhibiting Inflammatory Response.
Title: ALCAM Deficiency Alleviates LPS-Induced Acute Lung Injury by Inhibiting Inflammatory Response.
A Novel Regulatory Role of Activated Leukocyte Cell-Adhesion Molecule in the Pathogenesis of Pulmonary Fibrosis.
Title: A Novel Regulatory Role of Activated Leukocyte Cell-Adhesion Molecule in the Pathogenesis of Pulmonary Fibrosis.
The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses.
Title: The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses.
Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers.
Title: Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers.
the cell adhesion molecule ALCAM (CD166) can act as an extracellular substrate to selectively promote the growth of murine midbrain dopamine neuron axons through a trans-heterophilic interaction with adhesion molecules
Title: Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through Trans-Heterophilic Interactions with L1cam, Chl1, and Semaphorins.
The ALCAM+ giant cell tumor of bone cells showed the stem cell properties of self renewal and had the capacity to differentiate.
Title: ALCAM(+) stromal cells: role in giant cell tumor of bone progression.
These results indicate that ALCAM regulates food allergy by affecting T cell activation.
Title: Activated leucocyte cell adhesion molecule (ALCAM/CD166) regulates T cell responses in a murine model of food allergy.
Our data demonstrate that ALCAM KO mice develop a more severe active experimental autoimmune encephalomyelitis, which can be explained by an increased permeability of their BBB. This loss in BBB integrity is due to a dysregulation of junctional molecules caused by the lack of ALCAM at the level of the TJ molecules.
Title: Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis.
demonstrates for the first time the in vivo contribution of ALCAM to angiogenesis and reveals a novel role of stromally expressed ALCAM in supporting tumor growth and metastatic spread
Title: Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis.
Our results indicate that the loss of CD166 impacts hematopoietic stem cell numbers
Title: Activated leukocyte cell adhesion molecule (ALCAM or CD166) modulates bone phenotype and hematopoiesis.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI853494 (e-PCR)
- UniSTS:166026

Alcam (e-PCR), detects polymorphism
- UniSTS:498315

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of T cell receptor complex	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD166 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001331110.1 → NP_001318039.1 CD166 antigen isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC117780, AC154383, BE654940

Consensus CDS

CCDS84242.1

UniProtKB/TrEMBL

E9Q3Q6, E9Q4G8

Related

ENSMUSP00000129714.2, ENSMUST00000170035.8
NM_009655.3 → NP_033785.1 CD166 antigen isoform 1 precursor

See identical proteins and their annotated locations for NP_033785.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC154383, AK031391, AK161090, BE654940

Consensus CDS

CCDS37356.1

UniProtKB/Swiss-Prot

O70136, Q61490, Q8CDA5, Q8R2T0

UniProtKB/TrEMBL

E9Q4G8, Q54AJ5

Related

ENSMUSP00000023312.8, ENSMUST00000023312.14

Conserved Domains (4) summary

smart00410
Location:255 → 329

IG_like; Immunoglobulin like

pfam08205
Location:137 → 231

C2-set_2; CD80-like C2-set immunoglobulin domain

pfam13927
Location:256 → 313

Ig_3; Immunoglobulin domain

cl11960
Location:415 → 488

Ig; Immunoglobulin domain