Angpt1 angiopoietin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Angpt1provided by MGI
Official Full Name: angiopoietin 1provided by MGI
Primary source: MGI:MGI:108448
See related: Ensembl:ENSMUSG00000022309 AllianceGenome:MGI:108448
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ang1; Ang-1; 1110046O21Rik
Summary: This gene encodes a secreted glycoprotein that belongs to the angiopoietin family of vascular growth factors. The encoded protein is a ligand in the vascular tyrosine kinase signaling pathway and regulates the formation and stabilization of blood vessels. This protein also functions in striated muscles by promoting proliferation, migration and differentiation of skeletal myoblasts and plays an essential role in the vascular response to tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Expression: Broad expression in heart adult (RPKM 3.3), lung adult (RPKM 2.4) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 16.69 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (42288063..42540373, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (42424667..42676977, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Angiopoietin-1 Is Required for Vortex Vein and Choriocapillaris Development in Mice.
Title: Angiopoietin-1 Is Required for Vortex Vein and Choriocapillaris Development in Mice.
Effect of Novel Biotherapeutic Elevating Angiopoietin 1 on Progression of Diabetic Nephropathy in Diabetic/Obese Mice.
Title: Effect of Novel Biotherapeutic Elevating Angiopoietin 1 on Progression of Diabetic Nephropathy in Diabetic/Obese Mice.
Dual Targeting of Angipoietin-1 and von Willebrand Factor by microRNA-671-5p Attenuates Liver Angiogenesis and Fibrosis.
Title: Dual Targeting of Angipoietin-1 and von Willebrand Factor by microRNA-671-5p Attenuates Liver Angiogenesis and Fibrosis.
Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF/PI3k/Akt/eNOS pathway.
Title: Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF/PI3k/Akt/eNOS pathway.
Sulfated glycans engage the Ang-Tie pathway to regulate vascular development.
Title: Sulfated glycans engage the Ang-Tie pathway to regulate vascular development.
Inhibition of microRNA-711 limits angiopoietin-1 and Akt changes, tissue damage, and motor dysfunction after contusive spinal cord injury in mice.
Title: Inhibition of microRNA-711 limits angiopoietin-1 and Akt changes, tissue damage, and motor dysfunction after contusive spinal cord injury in mice.
Study of ApoE-/- mice transfected with Ang-1 encoding lentiviral vector suggested that Ang-1 acted as promoter of atherosclerosis through reduction of macrophage cholesterol efflux via binding to Tie2. Ang-1 incubated with human THP-1 derived macrophages activated the Tie2/TFE3 pathway to reduce LXRalpha-mediated ABCA1 and ABCG1 expression and subsequent cholesterol efflux.
Title: Angiopoietin-1 aggravates atherosclerosis by inhibiting cholesterol efflux and promoting inflammatory response.
published rodent data suggest that angiopoietin-1 upregulation improves outcome following temporary cerebral ischaemia by reducing cerebral infarction size and improving blood-brain barrier integrity.
Title: The effect of angiopoietin-1 upregulation on the outcome of acute ischaemic stroke in rodent models: A meta-analysis.
accelerates Alzheimer's disease via FOXA2/PEN2/APP pathway in APP/PS1 mice
Title: Angiopoietin-1 accelerates Alzheimer's disease via FOXA2/PEN2/APP pathway in APP/PS1 mice.
miR-711-dependent downregulation of Ang-1...may play a role in neuronal cell death after neuronal injury in vitro and after experimental traumatic brain injury.
Title: MicroRNA-711-Induced Downregulation of Angiopoietin-1 Mediates Neuronal Cell Death.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Angpt1 (e-PCR), detects polymorphism
- UniSTS:498458

Angpt1 (e-PCR), detects polymorphism
- UniSTS:498721

Angpt1 (e-PCR), detects polymorphism
- UniSTS:471085

Angpt1 (e-PCR), detects polymorphism
- UniSTS:545845

02.MMHAP64FRA8.seq (e-PCR)
- UniSTS:122709

D15Mit206 (e-PCR), detects polymorphism
- UniSTS:127574

PMC316637P2 (e-PCR)
- UniSTS:273024

Angpt1 (e-PCR), detects polymorphism
- UniSTS:496821

BE200393 (e-PCR)
- UniSTS:209084

Agpt (e-PCR), detects polymorphism
- UniSTS:166624

Agpt (e-PCR), detects polymorphism
- UniSTS:141051

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Tie signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Tie signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Tie signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in activation of transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branching involved in blood vessel morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in cardiac muscle tissue morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in endocardium morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within endoderm development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within glomerulus vasculature development	IDA Inferred from Direct Assay more info	PubMed
involved_in glomerulus vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
involved_in heparin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cytokine production involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of vascular permeability	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood-brain barrier permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_positive_effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of macrophage migration inhibitory factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of skeletal muscle satellite cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	TAS Traceable Author Statement more info	PubMed
involved_in vasculogenesis involved in coronary vascular morphogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiopoietin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286062.1 → NP_001272991.1 angiopoietin-1 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This encoded protein (isoform 2) is shorter than isoform 1.

Source sequence(s)

AC100734, AC101713, AC161347

UniProtKB/TrEMBL

Q8C2K6

Conserved Domains (2) summary

cd00087
Location:280 → 495

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl23720
Location:161 → 272

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_009640.4 → NP_033770.2 angiopoietin-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_033770.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC100734, AC101713, BC067410

Consensus CDS

CCDS27450.1

UniProtKB/Swiss-Prot

O08538, Q6NWV7

UniProtKB/TrEMBL

Q8C2K6

Related

ENSMUSP00000022921.6, ENSMUST00000022921.7

Conserved Domains (2) summary

cd00087
Location:281 → 496

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl23720
Location:133 → 238

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

42288063..42540373 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520323.3 → XP_006520386.1 angiopoietin-1 isoform X1

UniProtKB/TrEMBL

Q8C2K6

Conserved Domains (2) summary

cd00087
Location:183 → 398

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam09787
Location:20 → 173

Golgin_A5; Golgin subfamily A member 5
XM_036159078.1 → XP_036014971.1 angiopoietin-1 isoform X3

Conserved Domains (2) summary

cd00087
Location:173 → 388

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

TIGR04523
Location:29 → 151

Mplasa_alph_rch; helix-rich Mycoplasma protein
XM_036159077.1 → XP_036014970.1 angiopoietin-1 isoform X2

Conserved Domains (2) summary

cd00087
Location:174 → 389

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

TIGR04523
Location:29 → 151

Mplasa_alph_rch; helix-rich Mycoplasma protein