Adrb3 adrenergic receptor, beta 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adrb3provided by MGI
Official Full Name: adrenergic receptor, beta 3provided by MGI
Primary source: MGI:MGI:87939
See related: Ensembl:ENSMUSG00000031489 AllianceGenome:MGI:87939
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adrb-3; beta 3-AR
Summary: Enables beta-3 adrenergic receptor binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; diet induced thermogenesis; and norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure. Located in membrane. Is expressed in central nervous system; early conceptus; oocyte; and retina. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; obesity; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 215.3), subcutaneous fat pad adult (RPKM 163.4) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 15.94 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (27715804..27720833, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (27225776..27230845, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.
Title: β3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.
Brown Adipocyte ADRB3 Mediates Cardioprotection via Suppressing Exosomal iNOS.
Title: Brown Adipocyte ADRB3 Mediates Cardioprotection via Suppressing Exosomal iNOS.
Loss of adipose TET proteins enhances beta-adrenergic responses and protects against obesity by epigenetic regulation of beta3-AR expression.
Title: Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression.
HIF-1-Dependent Induction of beta3 Adrenoceptor: Evidence from the Mouse Retina.
Title: HIF-1-Dependent Induction of β3 Adrenoceptor: Evidence from the Mouse Retina.
ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells.
Title: ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells.
beta3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity.
Title: β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity.
Depletion of beta3-adrenergic receptor relieves pressure overload-induced cardiac hypertrophy and heart failure via enhancing innate immune response.
Title: Depletion of β3-adrenergic receptor relieves pressure overload-induced cardiac hypertrophy and heart failure via enhancing innate immune response.
Impact of thermogenesis induced by chronic beta3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice.
Title: Impact of thermogenesis induced by chronic β3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice.
Oxytocin and 'social hyperthermia': Interaction with beta3-adrenergic receptor-mediated thermogenesis and significance for the expression of social behavior in male and female mice.
Title: Oxytocin and 'social hyperthermia': Interaction with β(3)-adrenergic receptor-mediated thermogenesis and significance for the expression of social behavior in male and female mice.
D-Mannitol Induces a Brown Fat-like Phenotype via a beta3-Adrenergic Receptor-Dependent Mechanism.
Title: D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

X72862 (e-PCR)
- UniSTS:159747

Adrb3 (e-PCR), detects polymorphism
- UniSTS:471070

UniSTS:471071 (e-PCR)
- UniSTS:471071

Adrb3 (e-PCR), detects polymorphism
- UniSTS:471071

NoName (e-PCR)
- UniSTS:494118

Adrb3_-_d8Rck5 (e-PCR)
- UniSTS:124718

ADRB3 (e-PCR)
- UniSTS:506234

PMC164531P1 (e-PCR)
- UniSTS:271495

NoName (e-PCR)
- UniSTS:489183

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables beta-3 adrenergic receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables beta3-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta3-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables epinephrine binding	IBA Inferred from Biological aspect of Ancestor more info
enables epinephrine binding	ISO Inferred from Sequence Orthology more info
contributes_to norepinephrine binding	ISO Inferred from Sequence Orthology more info
enables norepinephrine binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brown fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within diet induced thermogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heat generation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-3 adrenergic receptor

Names: Beta-3 AR; beta-3 adrenoceptor; beta-3 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013462.3 → NP_038490.2 beta-3 adrenergic receptor

See identical proteins and their annotated locations for NP_038490.2

Status: VALIDATED

Source sequence(s)

AC102544

Consensus CDS

CCDS22213.1

UniProtKB/Swiss-Prot

A2RS74, P25962, Q9QZ98

UniProtKB/TrEMBL

Q3UP63

Related

ENSMUSP00000080162.4, ENSMUST00000081438.10

Conserved Domains (2) summary

cd14964
Location:70 → 92

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:48 → 353

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

27715804..27720833 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243246.2 → XP_030099106.1 beta-3 adrenergic receptor isoform X1

UniProtKB/Swiss-Prot

A2RS74, P25962, Q9QZ98

UniProtKB/TrEMBL

Q3UP63

Conserved Domains (2) summary

cd14964
Location:70 → 92

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:48 → 353

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_030243247.2 → XP_030099107.1 beta-3 adrenergic receptor isoform X1

UniProtKB/Swiss-Prot

A2RS74, P25962, Q9QZ98

UniProtKB/TrEMBL

Q3UP63

Related

ENSMUSP00000113006.2, ENSMUST00000121838.2

Conserved Domains (2) summary

cd14964
Location:70 → 92

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:48 → 353

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily