Adm adrenomedullin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Admprovided by MGI
Official Full Name: adrenomedullinprovided by MGI
Primary source: MGI:MGI:108058
See related: Ensembl:ENSMUSG00000030790 AllianceGenome:MGI:108058
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AM
Summary: Predicted to enable adrenomedullin receptor binding activity. Involved in several processes, including negative regulation of vascular permeability; positive regulation of vasculogenesis; and vascular associated smooth muscle cell development. Acts upstream of or within several processes, including chordate embryonic development; heart development; and positive regulation of cell population proliferation. Predicted to be located in cytoplasm and extracellular space. Is expressed in several structures, including cardiovascular system; extraembryonic component; gut; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in brain infarction; breast cancer; pancreatic cancer; and pulmonary hypertension. Orthologous to human ADM (adrenomedullin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 8.4), adrenal adult (RPKM 7.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 57.7 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (110226864..110229027)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (110627657..110629820)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adrenomedullin, transcriptionally regulated by vitamin D receptors, alleviates atherosclerosis in mice through suppressing AMPK-mediated endothelial ferroptosis.
Title: Adrenomedullin, transcriptionally regulated by vitamin D receptors, alleviates atherosclerosis in mice through suppressing AMPK-mediated endothelial ferroptosis.
Adrenomedullin Deficiency Potentiates Lipopolysaccharide-Induced Experimental Bronchopulmonary Dysplasia in Neonatal Mice.
Title: Adrenomedullin Deficiency Potentiates Lipopolysaccharide-Induced Experimental Bronchopulmonary Dysplasia in Neonatal Mice.
Adrenomedullin Ameliorates Pulmonary Fibrosis by Regulating TGF-ss-Smads Signaling and Myofibroblast Differentiation.
Title: Adrenomedullin Ameliorates Pulmonary Fibrosis by Regulating TGF-ß-Smads Signaling and Myofibroblast Differentiation.
Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts.
Title: Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts.
Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin-Receptor Activity-Modifying Protein 2 System.
Title: Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin-Receptor Activity-Modifying Protein 2 System.
Adrenomedullin is an endogenous, epicardial-derived factor that drives reparative cardiac lymphangiogenesis and function via Cx43, and this represents a new therapeutic pathway for improving myocardial edema after injury.
Title: Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Connexin 43.
A novel gene targeting approach was presented in which PAMP (proadrenomedullin N-terminal 20 peptide) is deleted exclusively, while retaining the coding sequence for AM (adrenomedullin) peptide, and demonstrate that mice lacking PAMP are viable and fertile.
Title: Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival.
Up-regulated mRNA and protein levels of proadrenomedullin (ProADM) during acute myocardial infarction in mice and humans.
Title: Precursor proadrenomedullin influences cardiomyocyte survival and local inflammation related to myocardial infarction.
AM is an important regulator of endothelial cell function, angiogenesis, tumorigenesis, and brain response to ischemia.
Title: Lack of adrenomedullin in mouse endothelial cells results in defective angiogenesis, enhanced vascular permeability, less metastasis, and more brain damage.
The AM-RAMP2 system exerts crucial vasoprotective effects after vascular injury and could be a therapeutic target for the treatment of vascular diseases.
Title: Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adm (e-PCR), detects polymorphism
- UniSTS:531465

Adm (e-PCR), detects polymorphism
- UniSTS:532533

D1Wox34 (e-PCR)
- UniSTS:118086

PMC14636P1 (e-PCR)
- UniSTS:271007

Adm (e-PCR), detects polymorphism
- UniSTS:141037

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adrenomedullin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables adrenomedullin receptor binding	ISO Inferred from Sequence Orthology more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenomedullin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adrenomedullin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection regeneration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spongiotrophoblast layer development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular associated smooth muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pro-adrenomedullin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.