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    Adam7 a disintegrin and metallopeptidase domain 7 [ Mus musculus (house mouse) ]

    Gene ID: 11500, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Adam7provided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 7provided by MGI
    Primary source
    MGI:MGI:107247
    See related
    Ensembl:ENSMUSG00000022056 AllianceGenome:MGI:107247
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EAP1; EAPI; ADAM 7
    Summary
    This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is specifically expressed in epididymis where the encoded protein is transferred to the sperm surface during epididymal transit. This gene is located adjacent to a related gene from the ADAM family of proteins on chromosome 14. [provided by RefSeq, Oct 2015]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 292.3) See more
    Orthologs
    human all
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    Genomic context

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    See Adam7 in Genome Data Viewer
    Location:
    14 D1; 14 35.69 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (68734785..68771138, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (68497336..68533689, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22319 Neighboring gene STARR-seq mESC enhancer starr_37042 Neighboring gene STARR-seq mESC enhancer starr_37043 Neighboring gene STARR-positive B cell enhancer mm9_chr14:68910779-68911080 Neighboring gene STARR-seq mESC enhancer starr_37045 Neighboring gene STARR-seq mESC enhancer starr_37046 Neighboring gene predicted gene, 41190 Neighboring gene predicted gene, 31227 Neighboring gene STARR-seq mESC enhancer starr_37047 Neighboring gene predicted gene, 41191 Neighboring gene ADAM-like, decysin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane. Oh JS, et al. Mol Cells, 2009 Nov 30. PMID 19855936
    2. Cloning and characterization of a complementary DNA encoding a human epididymis-associated disintegrin and metalloprotease 7 protein. Lin YC, et al. Biol Reprod, 2001 Sep. PMID 11514362
    3. Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. Choi H, et al. Biol Reprod, 2015 Sep. PMID 26246218
    4. Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm. Han C, et al. J Cell Physiol, 2011 May. PMID 20945367
    5. Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. Ballock RT, et al. J Cell Physiol, 1994 May. PMID 8163572

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAM7 is required for normal fertility and is important for the maintenance of epididymal integrity and for sperm morphology
      Title: Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7.
    2. Suggest that Adam7 functions in fertilization through the formation of a complex with heat shock protein 5, calnexin and Itm2b during capacitation in sperm.
      Title: Identification of heat shock protein 5, calnexin and integral membrane protein 2B as Adam7-interacting membrane proteins in mouse sperm.
    3. This study provides new information regarding the unique mode of secretion and interaction of ADAM7 during the epididymis-to-sperm transfer process.
      Title: ADAM7 is associated with epididymosomes and integrated into sperm plasma membrane.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in epididymis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of sperm capacitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 7
    Names
    a disintegrin and metalloprotease domain (ADAM) 7
    epididymal apical protein I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007402.2 → NP_031428.2  disintegrin and metalloproteinase domain-containing protein 7 preproprotein

      See identical proteins and their annotated locations for NP_031428.2

      Status: REVIEWED

      Source sequence(s)
      AC154706, AF013107, AK136692
      Consensus CDS
      CCDS27234.1
      UniProtKB/Swiss-Prot
      F8VQC6, O35227
      Related
      ENSMUSP00000022640.8, ENSMUST00000022640.8
      Conserved Domains (6) summary
      smart00608
      Location:486 → 623
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:199 → 391
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:410 → 482
      Disintegrin; Disintegrin
      pfam01421
      Location:199 → 393
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:63 → 153
      Pep_M12B_propep; Reprolysin family propeptide
      cl14106
      Location:655 → 698
      Rifin_STEVOR; Rifin/stevor family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      68734785..68771138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35227.2 GenPept UniProtKB/Swiss-Prot:O35227

    Gene LinkOut

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