Adam15 ADAM metallopeptidase domain 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adam15provided by MGI
Official Full Name: ADAM metallopeptidase domain 15provided by MGI
Primary source: MGI:MGI:1333882
See related: Ensembl:ENSMUSG00000028041 AllianceGenome:MGI:1333882
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AD56; MDC15
Summary: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. This gene is prominently expressed in vascular cells, the endocardium, hypertrophic cells in developing bone, and specific areas of hippocampus and cerebellum. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Mice lacking the encoded protein have increased bone mass resulting from osteoblast proliferation, and exhibit reduced neovascularization in a mouse model for retinopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing. [provided by RefSeq, May 2016]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 62.5), colon adult (RPKM 58.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.07 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89246947..89257589, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89339640..89350028, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrin alpha3/alpha6 and alphaV are implicated in ADAM15-activated FAK and EGFR signalling pathway individually and promote non-small-cell lung cancer progression.
Title: Integrin α3/α6 and αV are implicated in ADAM15-activated FAK and EGFR signalling pathway individually and promote non-small-cell lung cancer progression.
ADAM15 is required for optimal collagen cross-linking and scar formation following myocardial infarction.
Title: ADAM15 is required for optimal collagen cross-linking and scar formation following myocardial infarction.
A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice.
Title: A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice.
ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)-Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm.
Title: ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)-Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm.
endothelial progenitor cells (EPCs) transplantation exerted its therapeutic effect of acute lung injury (ALI) via increasing miR-10a/b-5p and reducing ADAM15, thus providing a novel insight into the molecular mechanism of EPC transplantation in treating ALI
Title: Endothelial progenitor cell transplantation attenuates lipopolysaccharide-induced acute lung injury via regulating miR-10a/b-5p.
ADAM15 has a critical role in mediating vascular barrier dysfunction during inflammation. Its mechanisms of action involve CD44 shedding and endothelial glycocalyx injury.
Title: A disintegrin and metalloproteinase 15-mediated glycocalyx shedding contributes to vascular leakage during inflammation.
the catalytic activity of ADAM15 is not crucial for its function in promoting pathological neovascularization in the mouse OIR model, most likely because of the very limited substrate repertoire of ADAM15.
Title: Characterization of oxygen-induced retinopathy in mice carrying an inactivating point mutation in the catalytic site of ADAM15.
ADAM15 upregulation contributes to inflammatory lung injury by promoting endothelial hyperpermeability and neutrophil transmigration.
Title: ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice.
A disintegrin and metalloproteinase 15 contributes to atherosclerosis by mediating endothelial barrier dysfunction via Src family kinase activity.
Title: A disintegrin and metalloproteinase 15 contributes to atherosclerosis by mediating endothelial barrier dysfunction via Src family kinase activity.
Adult Adam15(-/-) mice displayed an increase in bone volume and thickness with an increase in the number and activity of osteoblasts, whereas osteoclasts were apparently unaffected.
Title: Lack of ADAM15 in mice is associated with increased osteoblast function and bone mass.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cardiac epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to phorbol 13-acetate 12-myristate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within collagen catabolic process	IEA Inferred from Electronic Annotation more info
involved_in immune response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor binding	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 15

Names: a disintegrin and metallopeptidase domain 15 (metargidin); a disintegrin and metalloprotease domain 15 (metargidin); metalloprotease RGD disintegrin protein; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037722.4 → NP_001032811.2 disintegrin and metalloproteinase domain-containing protein 15 isoform a preproprotein

See identical proteins and their annotated locations for NP_001032811.2

Status: VALIDATED

Source sequence(s)

AC171273

Consensus CDS

CCDS17502.1

UniProtKB/Swiss-Prot

A4ZYV2, O88839, Q3TDN7, Q3U7C2, Q3UE21, Q8C7Z0, Q91VS9, Q9QYL2

UniProtKB/TrEMBL

Q3TD57

Related

ENSMUSP00000029676.6, ENSMUST00000029676.12

Conserved Domains (5) summary

smart00050
Location:431 → 504

DISIN; Homologues of snake disintegrins

smart00608
Location:509 → 650

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:214 → 412

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:214 → 414

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:67 → 155

Pep_M12B_propep; Reprolysin family propeptide
NM_001409479.1 → NP_001396408.1 disintegrin and metalloproteinase domain-containing protein 15 isoform c preproprotein

Status: VALIDATED

Source sequence(s)

AC171273
NM_001409480.1 → NP_001396409.1 disintegrin and metalloproteinase domain-containing protein 15 isoform d preproprotein

Status: VALIDATED

Source sequence(s)

AC171273
NM_001409481.1 → NP_001396410.1 disintegrin and metalloproteinase domain-containing protein 15 isoform e preproprotein

Status: VALIDATED

Source sequence(s)

AC171273
NM_001409482.1 → NP_001396411.1 disintegrin and metalloproteinase domain-containing protein 15 isoform f precursor

Status: VALIDATED

Source sequence(s)

AC171273
NM_001409483.1 → NP_001396412.1 disintegrin and metalloproteinase domain-containing protein 15 isoform g precursor

Status: VALIDATED

Source sequence(s)

AC171273

Related

ENSMUSP00000103072.3, ENSMUST00000107448.9
NM_001409484.1 → NP_001396413.1 disintegrin and metalloproteinase domain-containing protein 15 isoform h precursor

Status: VALIDATED

Source sequence(s)

AC171273
NM_001409485.1 → NP_001396414.1 disintegrin and metalloproteinase domain-containing protein 15 isoform i

Status: VALIDATED

Source sequence(s)

AC171273
NM_001409486.1 → NP_001396415.1 disintegrin and metalloproteinase domain-containing protein 15 isoform j precursor

Status: VALIDATED

Source sequence(s)

AC171273
NM_001409487.1 → NP_001396416.1 disintegrin and metalloproteinase domain-containing protein 15 isoform k precursor

Status: VALIDATED

Source sequence(s)

AC171273
NM_001409488.1 → NP_001396417.1 disintegrin and metalloproteinase domain-containing protein 15 isoform m

Status: VALIDATED

Source sequence(s)

AC171273
NM_001409489.1 → NP_001396418.1 disintegrin and metalloproteinase domain-containing protein 15 isoform l

Status: VALIDATED

Source sequence(s)

AC171273
NM_009614.4 → NP_033744.1 disintegrin and metalloproteinase domain-containing protein 15 isoform b precursor

See identical proteins and their annotated locations for NP_033744.1

Status: VALIDATED

Source sequence(s)

AC171273

Consensus CDS

CCDS17503.1

UniProtKB/TrEMBL

Q3TD57

Related

ENSMUSP00000074167.7, ENSMUST00000074582.7

Conserved Domains (5) summary

smart00050
Location:431 → 504

DISIN; Homologues of snake disintegrins

smart00608
Location:509 → 650

ACR; ADAM Cysteine-Rich Domain

cd04269
Location:214 → 412

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01421
Location:214 → 414

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:67 → 155

Pep_M12B_propep; Reprolysin family propeptide