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    Crip3 cysteine-rich protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 114570, updated on 2-May-2024

    Summary

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    Official Symbol
    Crip3provided by MGI
    Official Full Name
    cysteine-rich protein 3provided by MGI
    Primary source
    MGI:MGI:2152434
    See related
    Ensembl:ENSMUSG00000023968 AllianceGenome:MGI:2152434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TLP; Tlmp; TLP-A; TLP-B
    Summary
    Predicted to enable metal ion binding activity. Acts upstream of or within T cell proliferation. Located in cytoplasm. Is expressed in hemolymphoid system and urinary system. Orthologous to human CRIP3 (cysteine rich protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 33.4), ovary adult (RPKM 2.3) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 22.9 cM; 17 C
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46735058..46742706)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46428195..46431780)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC040756 Neighboring gene zinc finger protein 318 Neighboring gene predicted gene 9706 Neighboring gene solute carrier family 22 (organic anion transporter), member 7 Neighboring gene predicted gene, 36541 Neighboring gene ribosomal protein L11 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The human and mouse orthologous LIM-only proteins respectively encoded in chromosome 6 and 17 show a different expression pattern. Casrouge A, et al. Microbes Infect, 2004 Oct. PMID 15380775, Free PMC Article
    2. Identification and characterization of thymus LIM protein: targeted disruption reduces thymus cellularity. Kirchner J, et al. Mol Cell Biol, 2001 Dec. PMID 11713292, Free PMC Article
    3. The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family. Yu TS, et al. Mech Dev, 2002 Aug. PMID 12128222
    4. Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Chung YC, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 20932939
    5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine-rich protein 3
    Names
    CRP-3
    m17TLP
    thymus LIM protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053250.2 → NP_444480.1  cysteine-rich protein 3 isoform TLP-B

      See identical proteins and their annotated locations for NP_444480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (TLP-B) encodes the longer isoform (TLP-B).
      Source sequence(s)
      AC151275
      Consensus CDS
      CCDS37635.1
      UniProtKB/TrEMBL
      A0A0R4J1I1, A0A8I4Q0M4
      Related
      ENSMUSP00000109092.4, ENSMUST00000113465.10
      Conserved Domains (2) summary
      cd09476
      Location:5 → 58
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)
      cd09477
      Location:124 → 177
      LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)

    2. NM_181664.2 → NP_858050.1  cysteine-rich protein 3 isoform TLP-A

      See identical proteins and their annotated locations for NP_858050.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (TLP-A) has an alternate splice site in the 3' coding region, which results in frame shift, compared to variant TLP-B. The resulting isoform (TLP-A) has a shorter and distinct C-terminus, compared to isoform TLP-B.
      Source sequence(s)
      AC151275
      Consensus CDS
      CCDS28828.1
      UniProtKB/Swiss-Prot
      E9Q860, Q14B40, Q6Q6R3, Q91V23, Q91V60
      UniProtKB/TrEMBL
      A0A8Q0P6Q3
      Related
      ENSMUSP00000024764.6, ENSMUST00000024764.12
      Conserved Domains (2) summary
      cd09476
      Location:5 → 58
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)
      cd09477
      Location:124 → 177
      LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46735058..46742706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523489.2 → XP_006523552.1  cysteine-rich protein 3 isoform X1

      Conserved Domains (1) summary
      cd09477
      Location:116 → 169
      LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)

    2. XM_036160266.1 → XP_036016159.1  cysteine-rich protein 3 isoform X6

      Conserved Domains (1) summary
      cd09476
      Location:5 → 58
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)

    3. XM_006523490.2 → XP_006523553.1  cysteine-rich protein 3 isoform X2

      Conserved Domains (2) summary
      cd09477
      Location:114 → 167
      LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)
      cl02475
      Location:5 → 46
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_006523491.2 → XP_006523554.1  cysteine-rich protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I4Q0M4
      Conserved Domains (2) summary
      cd09477
      Location:95 → 148
      LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)
      cl02475
      Location:5 → 29
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    5. XM_006523496.4 → XP_006523559.1  cysteine-rich protein 3 isoform X7

      Conserved Domains (1) summary
      cd09476
      Location:5 → 58
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)

    6. XM_006523495.2 → XP_006523558.1  cysteine-rich protein 3 isoform X5

      Conserved Domains (1) summary
      cd09477
      Location:76 → 129
      LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)

    7. XM_006523494.1 → XP_006523557.1  cysteine-rich protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006523557.1

      Conserved Domains (1) summary
      cd09477
      Location:90 → 143
      LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)

    8. XM_006523493.1 → XP_006523556.1  cysteine-rich protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006523556.1

      Conserved Domains (1) summary
      cd09477
      Location:90 → 143
      LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)

    9. XM_006523492.1 → XP_006523555.1  cysteine-rich protein 3 isoform X4

      See identical proteins and their annotated locations for XP_006523555.1

      Conserved Domains (1) summary
      cd09477
      Location:90 → 143
      LIM2_TLP; The second LIM domain of thymus LIM protein (TLP)

    RNA

    1. XR_385264.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q6R3.2 GenPept UniProtKB/Swiss-Prot:Q6Q6R3

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