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    Zbtb21 zinc finger and BTB domain containing 21 [ Mus musculus (house mouse) ]

    Gene ID: 114565, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zbtb21provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 21provided by MGI
    Primary source
    MGI:MGI:1927240
    See related
    Ensembl:ENSMUSG00000046962 AllianceGenome:MGI:1927240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp295; Znf295; mKIAA1227; 5430437K12Rik; B430213I24Rik
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; POZ domain binding activity; and methyl-CpG binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; early conceptus; genitourinary system; and surface ectoderm. Orthologous to human ZBTB21 (zinc finger and BTB domain containing 21). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 2.0), limb E14.5 (RPKM 1.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 C4; 16 57.75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (97746993..97763850, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (97945795..97962627, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene PR domain containing 15 Neighboring gene C2 calcium-dependent domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_41640 Neighboring gene microRNA 6964 Neighboring gene predicted gene, 53924 Neighboring gene RIKEN cDNA C030010L15 gene Neighboring gene RIKEN cDNA B230307C23 gene Neighboring gene STARR-positive B cell enhancer ABC_E9939 Neighboring gene vomeronasal 2, receptor, pseudogene 112

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome. Akeson EC, et al. Cytogenet Cell Genet, 2001. PMID 11528125
    2. Evolutionary breakpoints on human chromosome 21. Davisson MT, et al. Genomics, 2001 Nov. PMID 11707078
    3. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    4. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    5. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables POZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 21
    Names
    zinc finger protein 295

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081684.2 → NP_001075153.1  zinc finger and BTB domain-containing protein 21 isoform 2

      See identical proteins and their annotated locations for NP_001075153.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream in-frame start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AC226122, AK034057
      Consensus CDS
      CCDS37420.1
      UniProtKB/TrEMBL
      E9Q3R9, Q3UM76
      Related
      ENSMUSP00000068283.8, ENSMUST00000063605.15
      Conserved Domains (5) summary
      sd00017
      Location:551 → 572
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:911 → 931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:673 → 695
      zf-C2H2; Zinc finger, C2H2 type
      cd18209
      Location:12 → 123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam18450
      Location:748 → 775
      zf_C2H2_6; Zinc Finger domain

    2. NM_001081685.2 → NP_001075154.1  zinc finger and BTB domain-containing protein 21 isoform 3

      See identical proteins and their annotated locations for NP_001075154.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses alternate splicing in the coding region but maintains the reading frame compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC226122, AK031118, AK034057
      Consensus CDS
      CCDS37419.1
      UniProtKB/TrEMBL
      G3X9A3, Q8BSP5
      Related
      ENSMUSP00000052127.8, ENSMUST00000052089.9
      Conserved Domains (4) summary
      sd00019
      Location:739 → 759
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:871 → 893
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:576 → 603
      zf_C2H2_6; Zinc Finger domain

    3. NM_001320385.1 → NP_001307314.1  zinc finger and BTB domain-containing protein 21 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks part of the 5' coding region, uses a downstream in-frame start codon, and uses alternate splicing in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC226122, AK034057
      Consensus CDS
      CCDS88980.1
      UniProtKB/TrEMBL
      Q80XC5
      Related
      ENSMUSP00000156033.2, ENSMUST00000232187.2
      Conserved Domains (3) summary
      sd00019
      Location:225 → 245
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:12 → 53
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam18450
      Location:62 → 89
      zf_C2H2_6; Zinc Finger domain

    4. NM_175428.4 → NP_780637.2  zinc finger and BTB domain-containing protein 21 isoform 1

      See identical proteins and their annotated locations for NP_780637.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC226122, AK034057
      Consensus CDS
      CCDS37418.1
      UniProtKB/TrEMBL
      E9Q444, Q6ZPV6
      Related
      ENSMUSP00000109363.3, ENSMUST00000113734.9
      Conserved Domains (6) summary
      sd00017
      Location:579 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:939 → 959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:701 → 723
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:776 → 803
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:576 → 629
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      97746993..97763850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159740.1 → XP_036015633.1  zinc finger and BTB domain-containing protein 21 isoform X3

      UniProtKB/TrEMBL
      G3X9A3, Q8BSP5
      Conserved Domains (4) summary
      sd00019
      Location:739 → 759
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:871 → 893
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:576 → 603
      zf_C2H2_6; Zinc Finger domain

    2. XM_006522858.5 → XP_006522921.1  zinc finger and BTB domain-containing protein 21 isoform X1

      See identical proteins and their annotated locations for XP_006522921.1

      UniProtKB/TrEMBL
      E9Q444, Q6ZPV6
      Conserved Domains (6) summary
      sd00017
      Location:579 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:939 → 959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:701 → 723
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:776 → 803
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:576 → 629
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    3. XM_006522861.5 → XP_006522924.1  zinc finger and BTB domain-containing protein 21 isoform X8

      Conserved Domains (3) summary
      sd00019
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:40 → 81
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam18450
      Location:90 → 117
      zf_C2H2_6; Zinc Finger domain

    4. XM_030248925.1 → XP_030104785.1  zinc finger and BTB domain-containing protein 21 isoform X4

      UniProtKB/TrEMBL
      Q8BSP5, Q8R0A4
      Conserved Domains (4) summary
      sd00019
      Location:711 → 731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:843 → 865
      zf-C2H2; Zinc finger, C2H2 type
      cd18209
      Location:12 → 123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam18450
      Location:548 → 575
      zf_C2H2_6; Zinc Finger domain

    5. XM_030248928.2 → XP_030104788.1  zinc finger and BTB domain-containing protein 21 isoform X9

      UniProtKB/TrEMBL
      Q80XC5
      Conserved Domains (3) summary
      sd00019
      Location:225 → 245
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:12 → 53
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam18450
      Location:62 → 89
      zf_C2H2_6; Zinc Finger domain

    6. XM_030248924.1 → XP_030104784.1  zinc finger and BTB domain-containing protein 21 isoform X3

      UniProtKB/TrEMBL
      G3X9A3, Q8BSP5
      Conserved Domains (4) summary
      sd00019
      Location:739 → 759
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:871 → 893
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:576 → 603
      zf_C2H2_6; Zinc Finger domain

    7. XM_030248927.2 → XP_030104787.1  zinc finger and BTB domain-containing protein 21 isoform X8

      Conserved Domains (3) summary
      sd00019
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:40 → 81
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam18450
      Location:90 → 117
      zf_C2H2_6; Zinc Finger domain

    8. XM_036159738.1 → XP_036015631.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/TrEMBL
      E9Q444, Q6ZPV6
      Conserved Domains (6) summary
      sd00017
      Location:579 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:939 → 959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:701 → 723
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:776 → 803
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:576 → 629
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    9. XM_036159742.1 → XP_036015635.1  zinc finger and BTB domain-containing protein 21 isoform X6

      Conserved Domains (5) summary
      sd00017
      Location:245 → 266
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:605 → 625
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:12 → 52
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam18450
      Location:442 → 469
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:242 → 295
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    10. XM_036159743.1 → XP_036015636.1  zinc finger and BTB domain-containing protein 21 isoform X7

      UniProtKB/TrEMBL
      Q8CDB1
      Conserved Domains (3) summary
      sd00019
      Location:433 → 453
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:40 → 80
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam18450
      Location:270 → 297
      zf_C2H2_6; Zinc Finger domain

    11. XM_036159741.1 → XP_036015634.1  zinc finger and BTB domain-containing protein 21 isoform X5

      Conserved Domains (4) summary
      sd00017
      Location:273 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:633 → 653
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:40 → 80
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam18450
      Location:470 → 497
      zf_C2H2_6; Zinc Finger domain

    12. XM_006522860.5 → XP_006522923.1  zinc finger and BTB domain-containing protein 21 isoform X2

      See identical proteins and their annotated locations for XP_006522923.1

      UniProtKB/TrEMBL
      E9Q3R9, Q3UM76
      Conserved Domains (5) summary
      sd00017
      Location:551 → 572
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:911 → 931
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:673 → 695
      zf-C2H2; Zinc finger, C2H2 type
      cd18209
      Location:12 → 123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam18450
      Location:748 → 775
      zf_C2H2_6; Zinc Finger domain

    13. XM_036159739.1 → XP_036015632.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/TrEMBL
      E9Q444, Q6ZPV6
      Conserved Domains (6) summary
      sd00017
      Location:579 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:939 → 959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:701 → 723
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:776 → 803
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:576 → 629
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    14. XM_030248926.2 → XP_030104786.1  zinc finger and BTB domain-containing protein 21 isoform X4

      UniProtKB/TrEMBL
      Q8BSP5, Q8R0A4
      Conserved Domains (4) summary
      sd00019
      Location:711 → 731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:843 → 865
      zf-C2H2; Zinc finger, C2H2 type
      cd18209
      Location:12 → 123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam18450
      Location:548 → 575
      zf_C2H2_6; Zinc Finger domain

    15. XM_030248923.2 → XP_030104783.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/TrEMBL
      E9Q444, Q6ZPV6
      Conserved Domains (6) summary
      sd00017
      Location:579 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:939 → 959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:701 → 723
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:776 → 803
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:576 → 629
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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