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    Chrng cholinergic receptor, nicotinic, gamma polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 11449, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Chrngprovided by MGI
    Official Full Name
    cholinergic receptor, nicotinic, gamma polypeptideprovided by MGI
    Primary source
    MGI:MGI:87895
    See related
    Ensembl:ENSMUSG00000026253 AllianceGenome:MGI:87895
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acrg; Achr-3
    Summary
    Enables acetylcholine-gated cation-selective channel activity. Acts upstream of or within regulation of membrane potential. Located in postsynaptic membrane. Part of acetylcholine-gated channel complex. Is expressed in several structures, including diaphragm; embryo mesenchyme; limb bud; skeletal musculature; and tongue. Human ortholog(s) of this gene implicated in multiple pterygium syndrome. Orthologous to human CHRNG (cholinergic receptor nicotinic gamma subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in limb E14.5 (RPKM 16.1), CNS E11.5 (RPKM 1.2) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C5; 1 44.07 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87133533..87139365)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87205811..87211835)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serine protease 56 Neighboring gene cholinergic receptor, nicotinic, delta polypeptide Neighboring gene eukaryotic translation initiation factor 4E member 2 Neighboring gene STARR-seq mESC enhancer starr_01608 Neighboring gene STARR-seq mESC enhancer starr_01609 Neighboring gene predicted gene, 53571 Neighboring gene predicted gene, 26187

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alternatively spliced variants of gamma-subunit of muscle-type acetylcholine receptor in fetal and adult skeletal muscle of mouse. Azim S, et al. Cell Mol Neurobiol, 2012 Aug. PMID 22488527
    2. Differential muscle-driven synaptic remodeling in the neuromuscular junction after denervation. Yampolsky P, et al. Eur J Neurosci, 2010 Feb. PMID 20148944
    3. AChR channel conversion and AChR-adjusted neuronal survival during embryonic development. Yampolsky P, et al. Mol Cell Neurosci, 2008 Mar. PMID 18226545
    4. Acetylcholine receptor channel subtype directs the innervation pattern of skeletal muscle. Koenen M, et al. EMBO Rep, 2005 Jun. PMID 15905852, Free PMC Article
    5. Spontaneous muscle action potentials fail to develop without fetal-type acetylcholine receptors. Takahashi M, et al. EMBO Rep, 2002 Jul. PMID 12101101, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The presence of two new transcript variants (T1 and T2) of chrng expressed in mouse postnatal day 3 and adult skeletal muscles, is reported.
      Title: Alternatively spliced variants of gamma-subunit of muscle-type acetylcholine receptor in fetal and adult skeletal muscle of mouse.
    2. hair cells transiently express alpha1gamma-containing nAChRs in addition to alpha9alpha10, and that these may have a role during development of the inner ear innervation
      Title: The α1 subunit of nicotinic acetylcholine receptors in the inner ear: transcriptional regulation by ATOH1 and co-expression with the γ subunit in hair cells.
    3. Results demonstrate that the gamma-subunit is required for the formation of pre-patterned AChR clusters, which in turn play an essential role in determining the subsequent pattern of neuromuscular synaptogenesis.
      Title: Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning.
    4. Results suggest a requirement for gamma-acetylcholine receptors in mediating synaptically-induced action potential activity critical for neuromuscular development.
      Title: Spontaneous muscle action potentials fail to develop without fetal-type acetylcholine receptors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine-gated monoatomic cation-selective channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine-gated monoatomic cation-selective channel activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of acetylcholine-gated channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    acetylcholine receptor subunit gamma
    Names
    nicotinic acetylcholine receptor gamma subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411849.1 → NP_001398778.1  acetylcholine receptor subunit gamma isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102611

    2. NM_009604.4 → NP_033734.3  acetylcholine receptor subunit gamma isoform 1 precursor

      See identical proteins and their annotated locations for NP_033734.3

      Status: VALIDATED

      Source sequence(s)
      AC102611
      Consensus CDS
      CCDS35651.1
      UniProtKB/Swiss-Prot
      P04760
      UniProtKB/TrEMBL
      F8VQK4
      Related
      ENSMUSP00000027470.8, ENSMUST00000027470.14
      Conserved Domains (3) summary
      TIGR00860
      Location:23 → 497
      LIC; Cation transporter family protein
      pfam02931
      Location:26 → 241
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:248 → 494
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      87133533..87139365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529078.3 → XP_006529141.1  acetylcholine receptor subunit gamma isoform X1

      UniProtKB/Swiss-Prot
      P04760
      Conserved Domains (2) summary
      cd19029
      Location:71 → 263
      LGIC_ECD_nAChR_G; extracellular domain of nicotinic acetylcholine receptor subunit gamma (CHRNG)
      pfam02932
      Location:270 → 515
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04760.1 GenPept UniProtKB/Swiss-Prot:P04760

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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