Ace angiotensin I converting enzyme [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aceprovided by MGI
Official Full Name: angiotensin I converting enzymeprovided by MGI
Primary source: MGI:MGI:87874
See related: Ensembl:ENSMUSG00000020681 AllianceGenome:MGI:87874
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD143
Summary: Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including cell proliferation in bone marrow; positive regulation of protein modification process; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 304.6), duodenum adult (RPKM 225.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 68.84 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (105858774..105880790)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (105967948..105989964)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Testicular ACE regulates sperm metabolism and fertilization through the transcription factor PPARgamma.
Title: Testicular ACE regulates sperm metabolism and fertilization through the transcription factor PPARγ.
Renal angiotensin I-converting enzyme-deficient mice are protected against aristolochic acid nephropathy.
Title: Renal angiotensin I-converting enzyme-deficient mice are protected against aristolochic acid nephropathy.
Angiotensin-converting enzyme gates brain circuit-specific plasticity via an endogenous opioid.
Title: Angiotensin-converting enzyme gates brain circuit-specific plasticity via an endogenous opioid.
Novel roles of the renal angiotensin-converting enzyme.
Title: Novel roles of the renal angiotensin-converting enzyme.
Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation.
Title: Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation.
ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP.
Title: ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP.
Natural angiotensin converting enzyme (ACE) C-domain-specific substrates are not well-described, and we propose that the peptide(s) responsible for the striking ACE-mediated enhancement of myeloid function are substrates/products of the ACE C-domain
Title: Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization.
ACE's two catalytically independent domains, the N- and C-domains, can process a variety of substrates other than angiotensin I. In models lacking either a functional ACE N-domain (NKO) or C-domain (CKO), in response to a saline challenge, diabetic NKO mice excreted 32% more urinary sodium compared with diabetic wild-type or CKO mice.
Title: The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease.
We show sex dimorphism in the severity of diabetes- and ANGII-related renal lesions, and demonstrate that ACE2- and ACE-related compensatory mechanisms are sex-specific. Supporting our previous findings, the modulation and ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy progression was more evident in males.
Title: Sex dimorphism in ANGII-mediated crosstalk between ACE2 and ACE in diabetic nephropathy.
Endothelial ACE is a central regulator of the glomerular filtration rate while tubular ACE is a key player in the development of tubular injury and albuminuria in diabetic mice.
Title: Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (17) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Mit13 (e-PCR), detects polymorphism
- UniSTS:126320

D10Wox18 (e-PCR)
- UniSTS:118139

AW208573 (e-PCR)
- UniSTS:180349

D10Mit1 (e-PCR), detects polymorphism
- UniSTS:118141

Ace (e-PCR), detects polymorphism
- UniSTS:141002

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables bradykinin receptor binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables chloride ion binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables exopeptidase activity	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-dipeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-dipeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-dipeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptidyl-dipeptidase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tripeptidyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta metabolic process	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis involved in coronary vascular morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in angiotensin maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in angiotensin maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiotensin maturation	ISO Inferred from Sequence Orthology more info
involved_in angiotensin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ regeneration	ISO Inferred from Sequence Orthology more info
involved_in arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in bradykinin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation in bone marrow	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in embryo development ending in birth or egg hatching	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hormone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hormone metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gap junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-cysteine S-nitrosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiotensin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of systemic arterial blood pressure by renin-angiotensin	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by renin-angiotensin	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substance P catabolic process	ISO Inferred from Sequence Orthology more info
involved_in vasoconstriction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiotensin-converting enzyme

Names: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; dipeptidyl carboxypeptidase I; dipeptidyl peptidase; kininase II

NP_001268748.1

EC 3.4.15.1

NP_033728.1

EC 3.4.15.1

NP_997507.1

EC 3.4.15.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.