Acads acyl-Coenzyme A dehydrogenase, short chain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acadsprovided by MGI
Official Full Name: acyl-Coenzyme A dehydrogenase, short chainprovided by MGI
Primary source: MGI:MGI:87868
See related: Ensembl:ENSMUSG00000029545 AllianceGenome:MGI:87868
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bcd1; SCAD; Bcd-1; Hdlq8
Summary: This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012]
Expression: Broad expression in colon adult (RPKM 134.5), adrenal adult (RPKM 130.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 55.99 cM; 5 F

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115248358..115257405, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115110299..115119346, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that the decreased beta-oxidation of short-chain fatty acids in Acads-deficient mice fed HF diet produces a state of energy deficiency in the brain.
Title: Brain transcriptional responses to high-fat diet in Acads-deficient mice reveal energy sensing pathways.
These results suggest that reduced brown adipose tissue function is not the major factor causing cold sensitivity in acyl-CoA dehydrogenase knockout strains.
Title: Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice.
some variants of SCAD proteins (R22W, G68C, W153R, and R359C) are severely misfolded, which may implicate a role in the pathogenesis of SCAD deficiency
Title: Misfolding, degradation, and aggregation of variant proteins. The molecular pathogenesis of short chain acyl-CoA dehydrogenase (SCAD) deficiency.
SCAD-deficient mice display altered postingestive responses to dietary fat, providing further evidence for metabolic control of feeding. Acads does not alter acute orosensory response to this fat stimulus.
Title: Mice bearing Acads mutation display altered postingestive but not 5-s orosensory response to dietary fat.

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Phenotypes

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Associated conditions

Description	Tests
HDL QTL 8 GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
QTL (2) 1 citation
Not Applicable (2) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI196007 (e-PCR)
- UniSTS:179244

Acads (e-PCR), detects polymorphism
- UniSTS:546622

Acads (e-PCR), detects polymorphism
- UniSTS:141000

Acads (e-PCR), detects polymorphism
- UniSTS:141001

D5Mit155 (e-PCR), detects polymorphism
- UniSTS:130281

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables butyryl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables butyryl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables fatty-acyl-CoA binding	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables short-chain fatty acyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in butyrate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in butyrate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: short-chain specific acyl-CoA dehydrogenase, mitochondrial

Names: butyryl-CoA dehydrogenase

NP_031409.2

EC 1.3.8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007383.3 → NP_031409.2 short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

See identical proteins and their annotated locations for NP_031409.2

Status: REVIEWED

Source sequence(s)

AK169428, BE993251, BY077302

Consensus CDS

CCDS19579.1

UniProtKB/Swiss-Prot

Q07417, Q91W85

Related

ENSMUSP00000031524.8, ENSMUST00000031524.11

Conserved Domains (1) summary

cd01158
Location:36 → 408

SCAD_SBCAD; Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases