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    Pzp PZP, alpha-2-macroglobulin like [ Mus musculus (house mouse) ]

    Gene ID: 11287, updated on 27-Feb-2024

    Summary

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    Official Symbol
    Pzpprovided by MGI
    Official Full Name
    PZP, alpha-2-macroglobulin likeprovided by MGI
    Primary source
    MGI:MGI:87854
    See related
    Ensembl:ENSMUSG00000030359 AllianceGenome:MGI:87854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A1m; A2m; MAM
    Summary
    Enables endopeptidase inhibitor activity. Acts upstream of or within embryo implantation. Located in collagen-containing extracellular matrix. Is expressed in liver and liver lobe. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    6 F3; 6 63.02 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128460530..128503683, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128483567..128526720, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10069 Neighboring gene STAM binding protein, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_17445 Neighboring gene STARR-positive B cell enhancer ABC_E6493 Neighboring gene peptidyl prolyl isomerase H pseudogene Neighboring gene mitochondrial intermembrane space import and assembly protein 40 pseudogene Neighboring gene predicted pseudogene 8724

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime. Jiang X, et al. Front Physiol, 2022. PMID 36051914, Free PMC Article
    2. Endometrial alpha-2 macroglobulin; localization by in situ hybridization and effect on mouse embryo development in vitro. Sayegh RA, et al. J Clin Endocrinol Metab, 1997 Dec. PMID 9398738
    3. The identification of alpha-2-macroglobulin in the mouse. Greene ND, et al. Biochim Biophys Acta, 1971 Jun 29. PMID 5559967
    4. Inhibition of nerve growth factor-stimulated neurite outgrowth by methylamine-modified alpha 2-macroglobulin. Koo PH, et al. J Neurosci Res, 1992 Apr. PMID 1374478
    5. Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice. Krause K, et al. Front Microbiol, 2019. PMID 30814992, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables brain-derived neurotrophic factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nerve growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo implantation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy zone protein
    Names
    alpha 1 macroglobulin
    alpha-2-M
    alpha-2-macroglobulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007376.4 → NP_031402.3  pregnancy zone protein precursor

      See identical proteins and their annotated locations for NP_031402.3

      Status: VALIDATED

      Source sequence(s)
      AC123060
      Consensus CDS
      CCDS39650.1
      UniProtKB/Swiss-Prot
      E9QPW0, Q60628, Q61838, Q6PEM2
      Related
      ENSMUSP00000107760.2, ENSMUST00000112132.8
      Conserved Domains (6) summary
      cd02897
      Location:970 → 1282
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:750 → 840
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:127 → 219
      A2M_N; MG2 domain
      pfam07677
      Location:1395 → 1482
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1022 → 1284
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:460 → 605
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      128460530..128503683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61838.3 GenPept UniProtKB/Swiss-Prot:Q61838

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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