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    Ifit1bl2 interferon induced protein with tetratricopeptide repeats 1B like 2 [ Mus musculus (house mouse) ]

    Gene ID: 112419, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Ifit1bl2provided by MGI
    Official Full Name
    interferon induced protein with tetratricopeptide repeats 1B like 2provided by MGI
    Primary source
    MGI:MGI:2148249
    See related
    Ensembl:ENSMUSG00000067297 AllianceGenome:MGI:2148249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ifit1b; 2010002M12Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to be active in cytosol. Orthologous to human IFIT1B (interferon induced protein with tetratricopeptide repeats 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 4.7), small intestine adult (RPKM 3.6) and 4 other tissues See more
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    Genomic context

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    Location:
    19 C1; 19 29.76 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34594446..34618163, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34617046..34640827, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11027 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3 Neighboring gene STARR-positive B cell enhancer ABC_E11028 Neighboring gene interferon induced protein with tetratricpeptide repeats 1B like 1 Neighboring gene STARR-positive B cell enhancer ABC_E5698 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3B Neighboring gene calponin2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45998 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1 Neighboring gene STARR-positive B cell enhancer ABC_E9997 Neighboring gene STARR-seq mESC enhancer starr_46000 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 12 Neighboring gene 60S ribosomal protein L36a-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c. Mears HV, et al. J Biol Chem, 2020 Dec 18. PMID 33454014, Free PMC Article
    2. Interferon-induced Ifit proteins: their role in viral pathogenesis. Fensterl V, et al. J Virol, 2015 Mar. PMID 25428874, Free PMC Article
    3. The broad-spectrum antiviral functions of IFIT and IFITM proteins. Diamond MS, et al. Nat Rev Immunol, 2013 Jan. PMID 23237964, Free PMC Article
    4. The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation. Langlais D, et al. J Exp Med, 2016 Apr 4. PMID 27001747, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
      Title: Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon induced protein with tetratricopeptide repeats 1B like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362130.1 → NP_001349059.1  interferon induced protein with tetratricopeptide repeats 1B like 2

      Status: VALIDATED

      Source sequence(s)
      AC016791
      Consensus CDS
      CCDS29765.1
      UniProtKB/TrEMBL
      Q3U687
      Conserved Domains (2) summary
      sd00006
      Location:282 → 329
      TPR; TPR repeat [structural motif]
      cl26002
      Location:63 → 353
      TPR_11; TPR repeat

    2. NM_053217.3 → NP_444447.1  interferon induced protein with tetratricopeptide repeats 1B like 2

      See identical proteins and their annotated locations for NP_444447.1

      Status: VALIDATED

      Source sequence(s)
      AK136525, AK153247
      Consensus CDS
      CCDS29765.1
      UniProtKB/TrEMBL
      Q3U687
      Related
      ENSMUSP00000093816.3, ENSMUST00000087357.5
      Conserved Domains (2) summary
      sd00006
      Location:282 → 329
      TPR; TPR repeat [structural motif]
      cl26002
      Location:63 → 353
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      34594446..34618163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250699.2 → XP_030106559.1  interferon induced protein with tetratricopeptide repeats 1B like 2 isoform X1

      Conserved Domains (3) summary
      TIGR02521
      Location:263 → 340
      type_IV_pilW; type IV pilus biogenesis/stability protein PilW
      TIGR02917
      Location:2 → 292
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:221 → 268
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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