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    Dxo decapping exoribonuclease [ Mus musculus (house mouse) ]

    Gene ID: 112403, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dxoprovided by MGI
    Official Full Name
    decapping exoribonucleaseprovided by MGI
    Primary source
    MGI:MGI:1890444
    See related
    Ensembl:ENSMUSG00000040482 AllianceGenome:MGI:1890444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NG6; Dom3z
    Summary
    Enables several functions, including 5'-3' exonuclease activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; and magnesium ion binding activity. Involved in RNA destabilization and nucleic acid metabolic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Orthologous to human DXO (decapping exoribonuclease). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 25.8), duodenum adult (RPKM 18.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dxo in Genome Data Viewer
    Location:
    17 B1; 17 18.39 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35055998..35058162)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34836996..34839187)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene Cyp21a1 5' regulatory region Neighboring gene complement C4A (Rodgers blood group) Neighboring gene STARR-seq mESC enhancer starr_42439 Neighboring gene C4a promoter region Neighboring gene C4a androgen-responsive enhancer Neighboring gene serine/threonine kinase 19 Neighboring gene STARR-positive B cell enhancer ABC_E8920 Neighboring gene SKI2 subunit of superkiller complex Neighboring gene microRNA 6971 Neighboring gene microRNA 6970

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs. Doamekpor SK, et al. Nucleic Acids Res, 2020 Jun 19. PMID 32374864, Free PMC Article
    2. Molecular mechanism for the inhibition of DXO by adenosine 3',5'-bisphosphate. Yun JS, et al. Biochem Biophys Res Commun, 2018 Sep 26. PMID 30180947, Free PMC Article
    3. 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. Jiao X, et al. Cell, 2017 Mar 9. PMID 28283058, Free PMC Article
    4. A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Jiao X, et al. Mol Cell, 2013 Apr 11. PMID 23523372, Free PMC Article
    5. A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes. Doamekpor SK, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31777937, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
      Title: DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
    2. A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes has been reported.
      Title: A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes.
    3. Report Dom3Z has role in pre-mRNA 5' end capping quality control mechanism and suggest link between proper 5' end capping and subsequent pre-mRNA processing.
      Title: A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA NAD+-cap (NAD+-forming) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 5'-diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD-cap decapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD-cap decapping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NAD-cap decapping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear mRNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    decapping and exoribonuclease protein
    Names
    5'-3' exoribonuclease DXO
    NAD-capped RNA hydrolase DXO
    deNADding enzyme DXO
    protein Dom3Z
    NP_001157242.1
    NP_001400546.1
    NP_001400547.1
    NP_291091.2
    XP_011244553.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163770.2 → NP_001157242.1  decapping and exoribonuclease protein isoform 1

      See identical proteins and their annotated locations for NP_001157242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      CT573030
      Consensus CDS
      CCDS28660.1
      UniProtKB/Swiss-Prot
      O70348, Q99KD8
      UniProtKB/TrEMBL
      A0A0R4J288
      Related
      ENSMUSP00000137234.2, ENSMUST00000180043.8
      Conserved Domains (1) summary
      pfam08652
      Location:235 → 302
      RAI1; RAI1 like PD-(D/E)XK nuclease

    2. NM_001413617.1 → NP_001400546.1  decapping and exoribonuclease protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT573030

    3. NM_001413618.1 → NP_001400547.1  decapping and exoribonuclease protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT573030

    4. NM_033613.3 → NP_291091.2  decapping and exoribonuclease protein isoform 1

      See identical proteins and their annotated locations for NP_291091.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      CT573030
      Consensus CDS
      CCDS28660.1
      UniProtKB/Swiss-Prot
      O70348, Q99KD8
      UniProtKB/TrEMBL
      A0A0R4J288
      Related
      ENSMUSP00000047018.9, ENSMUST00000046244.15
      Conserved Domains (1) summary
      pfam08652
      Location:235 → 302
      RAI1; RAI1 like PD-(D/E)XK nuclease

    RNA

    1. NR_182175.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT573030

    2. NR_182176.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT573030

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35055998..35058162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246251.4 → XP_011244553.1  decapping and exoribonuclease protein isoform X2

      See identical proteins and their annotated locations for XP_011244553.1

      UniProtKB/TrEMBL
      G3UZ39
      Related
      ENSMUSP00000134332.2, ENSMUST00000173874.8
      Conserved Domains (1) summary
      pfam08652
      Location:235 → 300
      RAI1; RAI1 like PD-(D/E)XK nuclease

    RNA

    1. XR_004939460.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70348.2 GenPept UniProtKB/Swiss-Prot:O70348

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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