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    Taar1 trace amine-associated receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 111174, updated on 22-Apr-2024

    Summary

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    Official Symbol
    Taar1provided by MGI
    Official Full Name
    trace amine-associated receptor 1provided by MGI
    Primary source
    MGI:MGI:2148258
    See related
    Ensembl:ENSMUSG00000056379 AllianceGenome:MGI:2148258
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tar1; Trar1; taR-1
    Summary
    Enables trace-amine receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Used to study schizophrenia. Orthologous to human TAAR1 (trace amine associated receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    Location:
    10 A4; 10 11.39 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (23796304..23797302)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (23920406..23921404)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26053 Neighboring gene vanin 3 Neighboring gene STARR-seq mESC enhancer starr_26055 Neighboring gene vanin 1 Neighboring gene STARR-seq mESC enhancer starr_26056 Neighboring gene trace amine-associated receptor 2 Neighboring gene trace amine-associated receptor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of trace amine-associated receptor 1 (TAAR1) transiently reduces alcohol drinking in socially housed mice. Frycz BA, et al. Addict Biol, 2023 Jul. PMID 37369127
    2. Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1). Zhukov IS, et al. Int J Mol Sci, 2022 Nov 15. PMID 36430544, Free PMC Article
    3. Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors. Phillips TJ, et al. Front Psychiatry, 2021. PMID 34512422, Free PMC Article
    4. Trace Amine-Associated Receptor 1 Contributes to Diverse Functional Actions of O-Phenyl-Iodotyramine in Mice but Not to the Effects of Monoamine-Based Antidepressants. Mantas I, et al. Int J Mol Sci, 2021 Aug 18. PMID 34445611, Free PMC Article
    5. Role of trace amine‑associated receptor 1 in the medial prefrontal cortex in chronic social stress-induced cognitive deficits in mice. Zhang Y, et al. Pharmacol Res, 2021 May. PMID 33753244

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAAR1 in dentate gyrus is involved in chronic stress-induced impairments in hippocampal plasticity and cognitive function.
      Title: TAAR1 in dentate gyrus is involved in chronic stress-induced impairments in hippocampal plasticity and cognitive function.
    2. Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
      Title: Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
    3. TAAR1 Regulates Purinergic-induced TNF Secretion from Peripheral, But Not CNS-resident, Macrophages.
      Title: TAAR1 Regulates Purinergic-induced TNF Secretion from Peripheral, But Not CNS-resident, Macrophages.
    4. Activation of trace amine-associated receptor 1 (TAAR1) transiently reduces alcohol drinking in socially housed mice.
      Title: Activation of trace amine-associated receptor 1 (TAAR1) transiently reduces alcohol drinking in socially housed mice.
    5. Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1).
      Title: Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1).
    6. A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake.
      Title: A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake.
    7. Role of trace amineassociated receptor 1 in the medial prefrontal cortex in chronic social stress-induced cognitive deficits in mice.
      Title: Role of trace amine‑associated receptor 1 in the medial prefrontal cortex in chronic social stress-induced cognitive deficits in mice.
    8. TAAR1-Dependent and -Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects of Monoamine Oxidase Inhibition.
      Title: TAAR1-Dependent and -Independent Actions of Tyramine in Interaction With Glutamate Underlie Central Effects of Monoamine Oxidase Inhibition.
    9. Differential genetic risk for methamphetamine intake confers differential sensitivity to the temperature-altering effects of other addictive drugs.
      Title: Differential genetic risk for methamphetamine intake confers differential sensitivity to the temperature-altering effects of other addictive drugs.
    10. Amphetamines signal through intracellular TAAR1 receptors coupled to Galpha13 and GalphaS in discrete subcellular domains.
      Title: Amphetamines signal through intracellular TAAR1 receptors coupled to Gα(13) and Gα(S) in discrete subcellular domains.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled amine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables trace-amine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables trace-amine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables trace-amine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    trace amine-associated receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053205.1 → NP_444435.1  trace amine-associated receptor 1

      See identical proteins and their annotated locations for NP_444435.1

      Status: PROVISIONAL

      Source sequence(s)
      AF380187
      Consensus CDS
      CCDS23735.1
      UniProtKB/Swiss-Prot
      Q05A85, Q923Y8
      Related
      ENSMUSP00000049527.5, ENSMUST00000051532.5
      Conserved Domains (2) summary
      pfam00001
      Location:39 → 301
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37 → 316
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      23796304..23797302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923Y8.1 GenPept UniProtKB/Swiss-Prot:Q923Y8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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