Hspa13 heat shock protein 70 family, member 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hspa13provided by MGI
Official Full Name: heat shock protein 70 family, member 13provided by MGI
Primary source: MGI:MGI:1309463
See related: Ensembl:ENSMUSG00000032932 AllianceGenome:MGI:1309463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Stch; 1600002I10Rik; B230217N24Rik
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Predicted to be involved in cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to be located in endoplasmic reticulum. Predicted to be active in mitochondrion. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human HSPA13 (heat shock protein family A (Hsp70) member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 10.3), CNS E18 (RPKM 6.6) and 23 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 16 C3.1; 16 43.36 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (75552078..75564575, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (75755190..75767276, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell atlas of splenocytes reveals a critical role of a novel plasma cellspecific marker Hspa13 in antibody class-switching recombination and somatic hypermutation.
Title: Single-cell atlas of splenocytes reveals a critical role of a novel plasma cell‒specific marker Hspa13 in antibody class-switching recombination and somatic hypermutation.
Hspa13 Promotes Plasma Cell Production and Antibody Secretion.
Title: Hspa13 Promotes Plasma Cell Production and Antibody Secretion.
Hspa13 (Stch) gene has a role in prion disease incubation time in mice
Title: Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Stch (e-PCR), detects polymorphism
- UniSTS:259149

AV006182 (e-PCR)
- UniSTS:180930

NoName (e-PCR)
- UniSTS:237530

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: heat shock 70 kDa protein 13

Names: heat shock protein 70kDa family, member 13; microsomal stress-70 protein ATPase core; stress 70 protein chaperone, microsome-associated, 60kD human homolog; stress 70 protein chaperone, microsome-associated, human homolog; stress-70 protein chaperone microsome-associated 60 kDa protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030201.3 → NP_084477.1 heat shock 70 kDa protein 13 precursor

See identical proteins and their annotated locations for NP_084477.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein.

Source sequence(s)

BC085181, BY133105, CO043820

Consensus CDS

CCDS28273.1

UniProtKB/Swiss-Prot

Q3TII6, Q8BM72, Q9D1X5

Related

ENSMUSP00000048817.9, ENSMUST00000046283.16

Conserved Domains (2) summary

cd10237
Location:12 → 463

HSPA13-like_NBD; Nucleotide-binding domain of human HSPA13 and similar proteins

PRK13930
Location:32 → 442

PRK13930; rod shape-determining protein MreB; Provisional

RNA

NR_027492.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK030553, BC085181, BY133105, CO043820