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    Slc18a1 solute carrier family 18 (vesicular monoamine), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 110877, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slc18a1provided by MGI
    Official Full Name
    solute carrier family 18 (vesicular monoamine), member 1provided by MGI
    Primary source
    MGI:MGI:106684
    See related
    Ensembl:ENSMUSG00000036330 AllianceGenome:MGI:106684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vat1; Vmat1; 4832416I10Rik
    Summary
    Predicted to enable enzyme binding activity and serotonin:sodium symporter activity. Predicted to be involved in aminergic neurotransmitter loading into synaptic vesicle; regulation of ion transport; and serotonin uptake. Predicted to act upstream of or within neurotransmitter transport. Located in synapse. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; immune system; and nervous system. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human SLC18A1 (solute carrier family 18 member A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 38.4), adrenal adult (RPKM 4.8) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc18a1 in Genome Data Viewer
    Location:
    8 B3.3; 8 33.88 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (69490360..69547951, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69037708..69089238, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32997 Neighboring gene predicted gene, 33103 Neighboring gene predicted gene, 33052 Neighboring gene STARR-seq mESC enhancer starr_21713 Neighboring gene STARR-seq mESC enhancer starr_21714 Neighboring gene STARR-positive B cell enhancer ABC_E8237 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit B2 Neighboring gene STARR-positive B cell enhancer ABC_E8238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71645510-71645697 Neighboring gene leucine zipper, putative tumor suppressor 1 Neighboring gene predicted gene, 39187 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71700363-71700564 Neighboring gene STARR-positive B cell enhancer ABC_E6640 Neighboring gene STARR-positive B cell enhancer ABC_E3775 Neighboring gene predicted gene, 39188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling. Lohoff FW, et al. Brain Res, 2019 Jun 1. PMID 30685272
    2. Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain. Ashe KM, et al. Neuro Endocrinol Lett, 2011. PMID 21712771
    3. Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety. Sato DX, et al. iScience, 2022 Aug 19. PMID 35992083, Free PMC Article
    4. VMAT1 deletion causes neuronal loss in the hippocampus and neurocognitive deficits in spatial discrimination. Multani PK, et al. Neuroscience, 2013 Mar 1. PMID 23201251, Free PMC Article
    5. Chromosomal localization of the human vesicular amine transporter genes. Peter D, et al. Genomics, 1993 Dec. PMID 7905859

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling.
      Title: Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling.
    2. Study shows that VMAT1 is expressed in mouse brain and plays a key role in survival of hippocampal neurons
      Title: VMAT1 deletion causes neuronal loss in the hippocampus and neurocognitive deficits in spatial discrimination.
    3. a functional VMAT-1 mRNA coding sequence is expressed in mouse brain and suggest processing of VMAT-1 protein differs in mouse adrenal and brain
      Title: Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (5)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28683, MGC37299

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoamine:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoamine:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serotonin:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serotonin:sodium:chloride symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminergic neurotransmitter loading into synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dopamine uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in norepinephrine uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in serotonin uptake IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chromaffin granule amine transporter
    Names
    solute carrier family 18 member 1
    vesicular amine transporter 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153054.2 → NP_694694.1  chromaffin granule amine transporter

      See identical proteins and their annotated locations for NP_694694.1

      Status: VALIDATED

      Source sequence(s)
      AC114995, AK076433, CN663918
      Consensus CDS
      CCDS22344.1
      UniProtKB/Swiss-Prot
      Q8R090
      UniProtKB/TrEMBL
      Q32XG7
      Related
      ENSMUSP00000046924.7, ENSMUST00000037478.13
      Conserved Domains (1) summary
      cd17384
      Location:127 → 475
      MFS_SLC18A1_2_VAT1_2; Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      69490360..69547951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509534.5 → XP_006509597.1  chromaffin granule amine transporter isoform X1

      See identical proteins and their annotated locations for XP_006509597.1

      UniProtKB/Swiss-Prot
      Q8R090
      UniProtKB/TrEMBL
      Q32XG7
      Conserved Domains (1) summary
      cd17384
      Location:127 → 475
      MFS_SLC18A1_2_VAT1_2; Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily

    2. XM_011242262.4 → XP_011240564.1  chromaffin granule amine transporter isoform X3

      Conserved Domains (1) summary
      cd17384
      Location:34 → 424
      MFS_SLC18A1_2_VAT1_2; Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily

    3. XM_017312522.3 → XP_017168011.1  chromaffin granule amine transporter isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:127 → 435
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R090.1 GenPept UniProtKB/Swiss-Prot:Q8R090

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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